“…Ipilimumab is a human monoclonal IgG1 antibody against CTLA-4 that has been shown to prolong the overall survival of advanced melanoma. The most common adverse events associated with ipilimumab are immune-related. …”
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“…Abstract Iris and ciliary body melanoma is an aggressive tumor, which, unfortunately, presents symptoms only in advanced stages and is often discovered accidentally during a routine eye examination. …”
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“…In this study, antineoplastic effects of honokiol were investigated in malignant melanoma models. In vitro effects of honokiol treatment on SKMEL-2 and UACC-62 melanoma cells were evaluated by measuring the cell viability, proliferation, apoptosis, cell cycle analysis, and expressions of various proteins associated with cell cycle progression and apoptosis. …”
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“…Metastatic melanoma is an aggressive disease that can spread to many organs of the body. …”
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“…We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. …”
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“…Patients with advanced melanoma have a compromised anti-tumor immune response leading to tumor immune tolerance and a tumor microenvironment conducive to disease progression. …”
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“…Uveal melanoma (UM) is a severe human malignancy with a high mortality rate that demands continued research into new and alternative forms of prevention and treatment. …”
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“…Melanoma is one of the most aggressive skin cancers with fiercely increasing incidence and mortality. …”
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“…Congenital melanocytic naevi (CMN) are a known risk factor for melanoma, with the greatest risk currently thought to be in childhood. …”
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“…Melanomas are malignant neoplasms originating from melanocytes. …”
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“…Melanoma is a malignant tumor of melanocytes and is considered to be the most aggressive cancer among all skin diseases. …”
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“…Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. …”
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“…Recent reports have shown efficacy and safety with the use of pembrolizumab, nivolumab, and ipilimumab for the treatment of different neoplasms, especially melanoma. In this article, we propose a review of the mechanisms of action involved in cancer immunology, the response evaluation of immunotherapies, and its toxicity profile, as well as a summary of the main clinical trials that led to the adoption of these new drugs for melanoma treatment.…”
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“…Primary melanoma of the oral cavity is extremely uncommon tumour consisting approximately 0.2 - 8.0% of all melanoma cases and 0.5% of all oral malignancies. …”
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“…Importance—Pediatric melanoma occurs, albeit rarely. Should patients be treated by today’s medical standards, or be subjected to medically unnecessary clinical studies? …”
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“…OBJECTIVE: The objective of the study was to summarize the role of DNA methylation in the development and metastasis of uveal melanoma (UM). DATA SOURCES: The relevant studies in MEDLINE were searched. …”
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