“…This Commentary discusses the transition from the dark ages to the age of enlightenment in melanoma immunotherapy and provides a roadmap for a better tomorrow for patients with metastatic melanoma.…”
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“…Considered to be rare, mucosal melanomas are rare type of melanoma that are found on mucosal surfaces and are primary or metastatic in origin. …”
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“…Over recent years, several new molecular and immunogenic therapeutic approaches to melanoma treatment have been approved and implemented in clinical practice. …”
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“…The regression of cutaneous melanomas does not necessarily guarantee prevention from the development of locoregional or distant metastases. …”
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“…The survival of patients with cutaneous melanoma can be accurately predicted using just four DNA methylation marks.…”
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“…Melanoma of the skin has become a prime example for demonstrating the success of targeted cancer therapy. …”
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“…Primary malignant melanoma of the esophagus is an extremely rare neoplasm arising from the esophageal mucosal melanocytes. …”
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“…However, vitiligo has been associated with cutaneous melanoma since the 1970s. Most of the antigens recognized by the immune system are expressed by both melanoma cells and normal melanocytes, explaining why the autoimmune response against melanocytes that led to vitiligo could be also present in melanoma patients. …”
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“…HSP90 is abundantly expressed in cancer, including melanoma. HSP90 client proteins are the key oncoproteins of several signaling pathways controlling melanoma development, progression and response to therapy. …”
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“…Primary malignant melanoma of the vagina is a rare gynaecological neoplasm with an aggressive course of disease. …”
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“…Melanoma cells display a metabolic reprogramming triggered by both genetic alterations and adaptation to a microenvironment that lacks nutrients and oxygen supply. …”
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“…Worldwide, the total incidence of cutaneous melanoma is higher in men than in women, with some differences related to ethnicity and age and, above all, sex and gender. …”
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“…Melanoma diagnosed during childbearing period or up to 1 year after delivery is defined as pregnancy-associated melanoma (PAM). …”
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“…PURPOSE: To report the prevalence of uveal melanoma in a Hospital database in Brazil over the period of 16 years (2000 to 2016). …”
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“…True multifocal uveal melanomas (>2melanomas in 1 eye) occurring in the same eye are very rare. …”
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“…Melanoma is the most aggressive and dangerous form of skin cancer that develops from transformed melanocytes. …”
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