“…A total of 47 samples of melanoma invaded LN from stage IIIb (AJCC 2007) melanoma patients treated with TIL plus IL-2 were included in this study. …”
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“…Serum lactate dehydrogenase (LDH) is a prognostic factor for patients with stage IV melanoma. To gain insights into the biology underlying this prognostic factor, we analyzed total serum LDH, serum LDH isoenzymes, and serum lactate in up to 49 patients with metastatic melanoma. …”
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“…Melanoma of the iris is a rare condition compared to posterior ocular tumors and in this case report we present a 51-year-old female patient with diffuse iris melanoma. …”
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“…Iris melanoma usually affects middle aged, Caucasian patients with light colored eyes. …”
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“…Patient: Male, 64 Final Diagnosis: Metastatic anorectal melanoma with endotracheal metastasis Symptoms: Fatigue • weight loss • hematochezia • cough Medication: None Clinical Procedure: Biopsy of anal mass • rigid bronchoscopy Specialty: Internal medicine • oncology • pulmonology OBJECTIVE: Rare disease BACKGROUND: Anorectal melanoma is a rare cancer with a poor prognosis. …”
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“…Type I BRAF inhibitors and immunotherapy constitute two new exciting approaches for the treatment of advanced malignant melanoma. We have recently elucidated a role for host C-C chemokine receptor type 2 (CCR2) in the antineoplastic effects of type I BRAF inhibitors in mice, supporting the therapeutic potential of combining BRAF inhibitors with immunotherapy.…”
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“…Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. …”
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“…Patient: Male, 55 Final Diagnosis: Melanoma Symptoms: Worsening constipation • tenesmus • weight loss Medication: — Clinical Procedure: Chemoradiation therapy Specialty: Oncology OBJECTIVE: Challenging differential diagnosis BACKGROUND: Malignant melanoma is usually readily diagnosed by the presence of melanin granules. …”
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“…A 45-year-old male presented with malignant melanoma of the left orbit in association with nevus of Ota. …”
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“…Malignant Melanoma is a high mortality neoplasm. The involvement of the nail apparatus is rare, with only 2 out of 3 patients seeking medical attention as the result of recent nail melanocytic lesions. …”
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“…Malignant melanoma can present a variety of histopathological patterns. …”
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“…Uveal melanoma (UM) is the most common primary malignant intraocular tumor in adults, with a 10-year cumulative metastatic rate of 34%. …”
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“…The full repertoire of human microRNAs (miRNAs) that could distinguish common (benign) nevi from cutaneous (malignant) melanomas remains to be established. In an effort to gain further insight into the role of miRNAs in melanoma, we applied Illumina next-generation sequencing (NGS) platform to carry out an in-depth analysis of miRNA transcriptome in biopsies of nevi, thick primary (>4.0 mm) and metastatic melanomas with matched normal skin in parallel to melanocytes and melanoma cell lines (both primary and metastatic) (n = 28). …”
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“…To examine trends in melanoma visits in the ambulatory care setting. Methods. …”
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“…Communication of familial risk of breast cancer and melanoma has the potential to educate relatives about their risk, and may also motivate them to engage in prevention and early detection practices. …”
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“…The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. …”
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“…Ipilimumab, a fully human anti-CTLA-4 antibody, has been approved for the treatment of unresectable or metastatic melanoma based on its survival benefit demonstrated in randomized phase III studies. …”
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“…An effective circulating tumour marker is needed for melanoma especially with the advent of targeted therapies. …”
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“…Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. …”
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