“…Studies in mice have shown that IL-23 plays a role in inhibiting the growth, progression, and metastasis of melanomas. Thus, therapeutic neutralization of IL-23 in patients may inadvertently increase their susceptibility to development of melanoma. …”
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“…PURPOSE: To report an extremely rare case of tapioca melanoma of the iris in an Iranian patient. CASE REPORT: A 50-year-old male patient presented with ocular pain and redness in the right eye for two weeks. …”
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“…Primary malignant melanoma (PMM) of the gastrointestinal tract is rare. …”
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“…PURPOSE: To assess the role of the canonical Wnt pathway via activation of β-catenin in tumor progression of conjunctival melanoma. METHODS: β-Catenin localization was assessed by immunohistochemistry in 43 conjunctival nevi, 48 primary acquired melanoses (PAM; conjunctival melanocytic intraepithelial neoplasia), and 44 conjunctival melanomas. …”
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“…Melanoma cell dormancy is regulated by intrinsic cues that maintain a slow-cycling state in cells and by extrinsic interactions with stromal and immune components of the microenvironment. …”
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“…The mitochondria isolated from healthy mouse livers were intravenously injected into melanoma model mice with lung metastasis, then the tumor growth, animal survival and associated metabolic changes were studied. …”
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“…PURPOSE: Mutation testing of the key genes involved in melanoma oncogenesis is now mandatory for the application of targeted therapeutics. …”
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“…Despite the association of melanoma and Vitiligo, the prognosis of melanoma is still fatal.…”
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“…The detection of metastases in patients with a diagnosis of uveal melanoma (UM) is a controversial issue. While only 1% of the patients have detectable metastases at the time of diagnosis, up to 30% of them will develop liver metastases within 5 years of treatment. …”
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“…Immune checkpoint inhibitors have improved patient survival in melanoma, but the innate resistance of many patients necessitates the investigation of alternative immune targets. …”
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“…Melanoma is one of the most lethal and malignant cancers and its incidence is increasing worldwide, and Japan is not an exception. …”
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“…Early recognition of melanoma in situ (MIS) is an ongoing challenge in dermatology. …”
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“…The aim of the present study was to investigate the effects of PMS on malignant melanoma and its molecular mechanisms. The malignant melanoma cell line A2058 was treated with different concentrations of PMS (0, 20, 80 and 160 µg/ml) for 24, 48 or 72 h, followed by cell viability detection using the Cell Counting Kit-8 assay. …”
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“…Uveal melanoma (UM) represents the most common intraocular malignancy in adults and accounts for about 5% of all melanomas. …”
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“…Melanoma is among the few cancers that demonstrate an increasing incidence over time. …”
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“…Melanoma is the most lethal form of skin cancer. Melanoma is usually curable with surgery if detected early, however, treatment options for patients with metastatic melanoma are limited and the five-year survival rate for metastatic melanoma had been 15–20% before the advent of immunotherapy. …”
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“…The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. …”
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“…OBJECTIVE: We assessed the generic and specific transferability of published CEAs of systemic treatments for advanced melanoma to the Irish setting. METHODS: CEAs of treatments for melanoma were identified by systematic review. …”
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