“…Malignant melanoma of the anorectum is a rare disorder. Patients often present with local symptoms similar to benign diseases. …”
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“…SIMPLE SUMMARY: Malignant melanoma is more dangerous than most other skin cancers due to its ability to spread early and aggressively. …”
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“…In addition, biological devices have developed, changing the approach to and treatment results in melanoma. In this review, we present different modalities to modulate the immune system, as well as opportunities and challenges in melanoma treatment.…”
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“…Targeting RTKs remains a significant challenge in melanoma, due to their variable expression across different melanoma stages of progression and among melanoma subtypes that consequently affect response to treatment and disease progression. …”
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“…SIMPLE SUMMARY: Immunotherapy has revolutionized the therapeutic landscape of melanoma. However, the absence of clinically validated predictive biomarkers is one of the major causes of unpredictable efficacy of immunotherapy. …”
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“…OBJECTIVES: We aimed to collect and report data from all patients who have been diagnosed with mucosal malignant melanoma to obtain the epidemiology and principles of current treatments. …”
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“…The management of melanoma patients with nodal metastases has undergone dramatic changes over the last decade. …”
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“…This article reviews the current knowledge of the effect of molecules secreted by adipose tissue-adipokines on melanoma progression. We also discuss the role of these factors as markers of incidence, metastasis, and melanoma patient survival. …”
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“…Gynecologic melanomas are rare and have a poor prognosis. Although immunotherapy (immune checkpoint inhibitors) and targeted therapy has greatly improved the systemic treatment of cutaneous melanoma (CM) in recent years, its efficacy in gynecologic melanomas remains uncertain because of the rarity of this malignancy and its scarce literature. …”
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“…Retinoblastoma in children and uveal melanoma in adults can pose a serious threat to both vision and life. …”
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“…SIMPLE SUMMARY: Cutaneous Melanoma is a form of skin cancer characterized by an elevated mutational load that favors high spread to distant organs and resistance to therapies. …”
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“…Malignant cutaneous melanoma (MCM) is the neoplasm that most often affects the heart. …”
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“…Sarcoidosis and sarcoid-like reactions have been associated with many solid tumors including malignant melanoma. There are reports of melanoma patients who develop sarcoidosis without having received any antineoplastic treatment, but there are also melanoma patients who have received immunotherapy or targeted therapy and, therefore, develop drug-associated sarcoidosis. …”
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“…Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. …”
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“…Patients with late-stage melanomas have poor prognosis as their five-year survival rate is only 27% while the survival rate for primary melanomas is 99%. …”
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“…There is, however, no doubt that other factors had a significant impact on the rising incidence of melanoma. Pre-1980s the clinical diagnosis of melanoma was based on gross criteria such as ulceration or bleeding. …”
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“…While the epidemiological curves of the 1980’s and 1990’s suggested an increase in the incidence of melanoma across all age groups, the last 10 years’ data indicates a 5% reduction in the incidence of thin melanoma in young individuals aged between 15 and 24. …”
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