“…BACKGROUND: Ipilimumab induces long-lasting clinical responses in a minority of patients with metastatic melanoma. To better understand the mechanism(s) of action and to identify novel biomarkers associated with the clinical benefit and toxicity of ipilimumab, baseline characteristics and changes in CD4(+) and CD8(+) T cells from melanoma patients receiving ipilimumab were characterized by gene profiling and flow cytometry. …”
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“…We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. …”
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“…What is the cellular origin of melanoma? What role do melanocyte stem cells (MSC) and other melanocyte precursors play in the development of melanoma? …”
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“…We present a case of angiomatoid fibrous histiocytoma on the upper arm of a 40-year-old female, which was initially misdiagnosed as metastatic melanoma in a lymph node. Revision of the pathology revealed an angiomatoid fibrous histiocytoma, which was later confirmed by a EWSR1-CREB1 translocation with molecular diagnostics. …”
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“…BACKGROUND: A primary cutaneous melanoma will not kill the patient, but its metastases. …”
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“…Melanoma is one of the most aggressive skin cancers due to its high capacity to metastasize. …”
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“…Uveal melanomas are a common clinical entity that initially present in a variety of ways. …”
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“…Metastatic melanoma lesions sometimes host ectopic lymphoid structures exhibiting ongoing adaptive immune responses. …”
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“…Amelanotic melanoma (AM) presents a diagnostic challenge due to its wide clinical presentations, lack of pigmentation, and varied histological appearances. …”
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“…The recent success of adoptive cell therapy against melanoma suggests that endogenous T-cell responses have the potential to control cancer. …”
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“…All patients enrolled in this study had histologically verified unresectable stage IV melanoma. Objective responses were induced in 12.5% of the patients, while 42.5% of them obtained short-term disease stabilization. …”
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“…The aim of this study was to review the available literature and identify recent advances in the classification and management of conjunctival melanoma (CM) for clinicians working in this field. …”
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“…Biopsy pathological examination revealed that the lesion was a melanoma. The Breslow depth was estimated at 3 mm, and Clark's level was IV. …”
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“…Brain metastases occur in 15% of patients with melanoma and are associated with a dismal prognosis. …”
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“…Using the experimental melanoma B16F1 cell line, we found that melanoma cells can express galectin-7 at the primary tumor site and in lung metastasis. …”
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“…We report here a rare case of metastatic malignant melanoma presenting as ileo-ileal intussusception. …”
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“…Cutaneous melanoma is a highly aggressive malignant tumor of skin melanocytes with an increasing incidence in most countries of the world, especially in the fair-skinned populations. …”
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“…Acral lentiginous melanoma (ALM) of the sole sometimes has a hyperkeratotic appearance and mimics a pigmented wart. …”
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“…Visceral metastatic spread of ocular melanoma most commonly occurs via hematogenous route to the liver. …”
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