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“…Mechanistically, nestin KD-dependent melanoma invasion was associated with intracellular redistribution of phosphorylated focal adhesion kinase (pFAK) and increased melanoma cell responsiveness to transforming growth factor-beta (TGF-β), both implicated in pathways of melanoma invasion. …”
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“…We present a case of a hyperkeratotic acral melanoma that has been misdiagnosed and that has led to an amputation of the thumb.…”
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“…Thus, vitamin C could be a potential epigenetic treatment for melanoma.…”
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“…PURPOSE: Proton beam therapy is a commonly accepted treatment for intraocular melanomas, but the literature is lacking in descriptions of patient preferences of clinical outcomes and economic impact. …”
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“…MET fusion kinases thus provide a potential therapeutic target for a rare subset of melanoma for which currently no targeted therapeutic options currently exist.…”
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“…Uveal melanoma is the most common malignancy of the adult eye. …”
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“…Glutamine dependence is a prominent feature of cancer metabolism, and here we show that melanoma cells, irrespective of their oncogenic background, depend on glutamine for growth. …”
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“…Since the mid-1950’s, melanoma incidence has been rising steadily in industrialized Caucasian populations, thereby pointing to the pivotal involvement of environmental factors in melanomagenesis. …”
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“…Many hematologic malignancies and solid tumors, including melanoma, have been associated with sarcoidosis. We describe the clinical and pathologic findings of a 54-year-old man with melanoma-associated sarcoidosis. …”
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“…BACKGROUND: Primary melanoma of the prostate has an extremely rare incidence. …”
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“…The therapeutic landscape for advanced melanoma has expanded in recent years. This expansion has largely been driven by investigational work in melanoma tumor biology and immunology that has been successfully translated to the clinical setting. …”
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“…Introduction. Primary malignant melanoma of the urethra is a rare tumour (0.2% of all melanomas) that most commonly affects the meatus and distal urethra and is three times more common in women than men. …”
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“…Somatic point mutations in the BRAF gene have been found in approximately 50% of melanomas. BRAF(V600E), the most common mutation, results in the constitutive activation of BRAF(V600E) kinase, sustaining MAPK signaling and perpetuating cell growth. …”
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“…BACKGROUND: In cases of early stage subungual melanoma (SUM), conservative treatment with non-amputative wide excision of the nail unit and subsequent skin graft is preferred over amputation to preserve the involved digit. …”
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“…Tissue microarray and immunohistochemical analysis were employed to study the expression of p-ATM in melanoma patients. A total of 366 melanoma patients (230 primary melanoma and 136 metastatic melanoma) were used for the study. …”
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“…Patients who have survived malignant melanoma for more than five years may lack the opportunity to talk about their burden. …”
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“…METHODS: To report on the role of SRS in the treatment of patients with brain metastases from malignant melanoma, a retrospective analysis of 381 intracranial melanoma metastases in 103 consecutive patients who underwent SRS between 2005 and 2011 at Beth Israel Deaconess Medical Center was conducted. …”
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“…Isolated metastases from melanoma are rare and could be found several months after primary diagnosis of melanoma. …”
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“…While BRAF-MEK inhibition is a standard, molecular targeted therapy in BRAF-mutated melanomas, its future utility has to be established in the rapidly changing landscape of immunotherapeutics.…”
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