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90301por Meng, Xiangtong, Dong, Shen, Yangyang, Liu, Wang, Song, Xu, Xiaohao, Liu, Tiejun, Zhuang, Xiong“…ABCC mRNA expression varied with gender (P < .05), except for ABCC11–13; with tumor grade (P < 0.05), except for ABCC7/12/13; with tumor stage (P < .05), except for ABCC11–13; and with lymph node metastasis status (P < .05), except for ABCC7/8/11/12/13. …”
Publicado 2022
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90302por Gu, Cheng-Yuan, Dai, Bo, Zhu, Yao, Lin, Guo-Wen, Wang, Hong-Kai, Ye, Ding-Wei, Qin, Xiao-Jian“…Angiogenesis plays the critical roles in promoting tumor progression, aggressiveness, and metastasis. Although few studies have revealed some angiogenesis-related genes (ARGs) could serve as prognosis-related biomarkers for the prostate cancer (PCa), the integrated role of ARGs has not been systematically studied. …”
Publicado 2022
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90303“…Previous research has suggested that necroptosis is involved in anti-tumor immunity and promotes oncogenesis and cancer metastasis, which in turn affects tumor prognosis. However, the role of necroptosis in ESCA is unclear. …”
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90304por Zhang, Xiaomiao, Zhao, Jingwei, Zhang, Qi, Wang, Sicong, Zhang, Jieying, An, Jusheng, Xie, Lizhi, Yu, Xiaoduo, Zhao, Xinming“…The combined model constructed with T stage, lymph node metastasis position, and radiomics score achieved the best performance for the estimation of PFS (C-index, 0.792 for training and 0.809 for testing) and OS (C-index, 0.822 for training and 0.785 for testing), which were significantly higher than those of the radiomics score (P < 0.05). …”
Publicado 2022
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90305por Zhou, Guangrun, Zheng, Jifang, Chen, Zhiwei, Hu, Dan, Li, Suyu, Zhuang, Wu, He, Zhiyong, Lin, Gen, Wu, Biao, Zhang, Wei, Fang, Weimin, Zheng, Fei, Wang, Jiezhong, Chen, Gang, Chen, Mingqiu“…H&E-sTILs that affected the overall survival (OS), progression free survival (PFS) and brain-metastasis free survival (BMFS) rates were explored using the Kaplan–Meier method, and the log-rank test was used to assess the differences. …”
Publicado 2022
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90306por Yu, Jie, Cheng, Zhi-Gang, Han, Zhi-Yu, Liu, Fang-Yi, Zheng, Rong-Qin, Cheng, Wen, Wei, Qiang, Yu, Song-Yuan, Li, Qin-ying, He, Guang-zhi, Luo, Yan-chun, Yu, Xiao-Ling, Liang, Ping“…The median intrahepatic metastasis time was 27.6 (95% confidence interval [CI]: 25.2–28.8) months, with 5- and 10-year occurrence rates of 68.8% and 79.4%, respectively. …”
Publicado 2022
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90307por Chen, Xueshu, Chen, Wei, Zhao, Yan, Wang, Qinrong, Wang, Wenling, Xiang, Yining, Yuan, Hang, Xie, Yuan, Zhou, Jianjiang“…CCK-8 assay, colony formation, flow cytometry, Transwell assay, and nude mouse xenograft model were used to determine the effects of Serpin E1 on cell proliferation and metastasis in vitro and in vivo. Finally, Serpin E1 and/or FAP expression was measured in H. pylori-infected gerbil gastric mucosa and human gastric cancer tissues. …”
Publicado 2022
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90308por Chan, Emily, McKenney, Jesse K., Hawley, Sarah, Corrigan, Dillon, Auman, Heidi, Newcomb, Lisa F., Boyer, Hilary D., Carroll, Peter R., Cooperberg, Matthew R., Klein, Eric, Fazli, Ladan, Gleave, Martin E., Hurtado-Coll, Antonio, Simko, Jeffry P., Nelson, Peter S., Thompson, Ian M., Tretiakova, Maria S., Troyer, Dean, True, Lawrence D., Vakar-Lopez, Funda, Lin, Daniel W., Brooks, James D., Feng, Ziding, Nguyen, Jane K.“…The >0.25 mm cut-off was validated as statistically significant in a separate 419 patient, completely embedded whole-section radical prostatectomy cohort by biochemical recurrence, metastasis-free survival, and disease specific death, even when cases with admixed Gleason pattern 5 carcinoma were excluded. …”
Publicado 2022
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90309por Zeman, Marcin, Skałba, Władysław, Wilk, Agata Małgorzata, Cortez, Alexander Jorge, Maciejewski, Adam, Czarniecka, Agnieszka“…Other factors affecting OS included age (HR: 1.044, 95% CI: 1.016–1.073, p = 0.002), regional lymph node metastasis (ypN +) (HR: 2.157, 95% CI: 1.395–3.334, p = 0.001) and perineural invasion (PNI) (HR: 3.864, 95% CI: 1.799–8.301, p = 0.001). …”
Publicado 2022
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90310“…Recently, there is an emerging study showed that post-translational modifications (PTMs) by glycosylation is an important process correlated with tumor angiogenesis, invasion and metastasis. Herein, we reported a data-driven discovery and experimental validation of GANAB, a key regulator of glycosylation, as a novel prognostic marker in UC. …”
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90311por Marconi, Silvia, Croce, Michela, Chiorino, Giovanna, Rossi, Giovanni, Guana, Francesca, Profumo, Aldo, Ostano, Paola, Alama, Angela, Longo, Luca, De Luca, Giuseppa, Dono, Mariella, Dal Bello, Maria Giovanna, Ponassi, Marco, Rosano, Camillo, Romano, Paolo, Cavalieri, Zita, Grassi, Massimiliano, Tagliamento, Marco, Zullo, Lodovica, Venturi, Consuelo, Dellepiane, Chiara, Mastracci, Luca, Bennicelli, Elisa, Pronzato, Paolo, Genova, Carlo, Coco, Simona“…Moreover, in vitro transfections showed that higher levels of miR-130a-3p lead to a deregulation of pathways involved in metastasis and angiogenesis, including the coagulation process and metalloprotease increase which might be linked to FpA reduction. …”
Publicado 2022
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90312“…METHODS: We searched the PubMed, Embase, and Scopus databases for studies comparing CCRT versus RT alone in stage II NPC with survival outcomes and toxicities, including locoregional recurrence-free survival (LRFS), metastasis-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and grade 3–4 acute toxicities. …”
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90313por Heinzel, Alexander, Dedic, Daniela, Galldiks, Norbert, Lohmann, Philipp, Stoffels, Gabriele, Filss, Christian P., Kocher, Martin, Migliorini, Filippo, Dillen, Kim N. H., Geisler, Stefanie, Stegmayr, Carina, Willuweit, Antje, Sabel, Michael, Rapp, Marion, Eble, Michael J., Piroth, Marc, Clusmann, Hans, Delev, Daniel, Bauer, Elena K., Ceccon, Garry, Dunkl, Veronika, Rosen, Jurij, Tscherpel, Caroline, Werner, Jan-Michael, Ruge, Maximilian I., Goldbrunner, Roland, Hampl, Jürgen, Weiss Lucas, Carolin, Herrlinger, Ulrich, Maurer, Gabriele D., Steinbach, Joachim P., Mauler, Jörg, Worthoff, Wieland A., Neumaier, Bernd N., Lerche, Christoph, Fink, Gereon R., Shah, Nadim Jon, Mottaghy, Felix M., Langen, Karl-Josef“…In 2019, indications for the use of FET PET were as follows: suspected recurrent glioma (46%), unclear brain lesions (20%), treatment monitoring (19%), and suspected recurrent brain metastasis (13%). The referring physicians were neurosurgeons (60%), neurologists (19%), radiation oncologists (11%), general oncologists (3%), and other physicians (7%). …”
Publicado 2022
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90314por Zhu, Hongcheng, Liu, Qiufang, Xu, Hao, Mo, Miao, Wang, Zezhou, Lu, Kui, Zhou, Jialiang, Chen, Junqiang, Zheng, Xiangpeng, Ye, Jinjun, Ge, Xiaolin, Luo, Honglei, Liu, Qi, Deng, Jiaying, Ai, Dashan, Hao, Shengnan, Zhang, Junhua, Tseng, I Hsuan, Song, Shaoli, Chen, Yun, Zhao, Kuaile“…Patients with histologically confirmed ESCC [T1N1-3M0, T2-4NxM0, TxNxM1 (Supraclavicular lymph node metastasis only), (AJCC Cancer Staging Manual, 8th Edition)] and without any prior treatment of chemotherapy, radiotherapy or surgery against esophageal cancer will be eligible. …”
Publicado 2022
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90315por Lu, Yuan-Fei, Zhou, Jia-Ping, Zhou, Qiao-Mei, Yang, Xiao-Yan, Wang, Xiao-Jie, Yu, Jie-Ni, Zhang, Jin-Guo, Du, Yong-Zhong, Yu, Ri-Sheng“…CONCLUSIONS: In summary, the three combinations of PTT, NR2F6 gene ablation and anti-PD-L1 can promote a synergistic immune response to inhibit the progression of primary HCC tumors and prevent metastasis. This study can be considered a proof-of-concept for the targeting of surface and intracellular immune checkpoints to supplement the existing HCC immunotherapy treatments. …”
Publicado 2022
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90316por Jia, Jianlong, Ga, Latai, Liu, Yang, Yang, Zhiyi, Wang, Yue, Guo, Xuanze, Ma, Ruichen, Liu, Ruonan, Li, Tianyou, Tang, Zeyao, Wang, Jun“…Secondly, in the in vitro and/or in vivo murine models, the wet-lab experiments demonstrated that SPINK1 promoted the proliferation, clonal formation, migration, chemoresistance, anti-apoptosis, tumorigenesis, and metastasis of HCC cells, while the anti-SPINK1 antibody inhibited the growth of the cells, suggesting that SPINK1 has “tumor marker” and “targetable” characteristics in the management of HCC. …”
Publicado 2022
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90317“…These patients were randomized into control and intervention groups (n = 58 per group), but during the implementation of the project, there was one dropout in the control group due to the loss of follow-up, and one dropout in the intervention group due to distant metastasis. In the end, 57 patients in the control and intervention groups completed the trial. …”
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90318por Theophanous, Stelios, Lønne, Per-Ivar, Choudhury, Ananya, Berbee, Maaike, Dekker, Andre, Dennis, Kristopher, Dewdney, Alice, Gambacorta, Maria Antonietta, Gilbert, Alexandra, Guren, Marianne Grønlie, Holloway, Lois, Jadon, Rashmi, Kochhar, Rohit, Mohamed, Ahmed Allam, Muirhead, Rebecca, Parés, Oriol, Raszewski, Lukasz, Roy, Rajarshi, Scarsbrook, Andrew, Sebag-Montefiore, David, Spezi, Emiliano, Spindler, Karen-Lise Garm, van Triest, Baukelien, Vassiliou, Vassilios, Malinen, Eirik, Wee, Leonard, Appelt, Ane L.“…METHODS: This is a retrospective multi-centre cohort study, investigating overall survival, locoregional control and freedom from distant metastasis after primary chemoradiotherapy for anal squamous cell carcinoma. …”
Publicado 2022
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90319por Yu, Xiao-Jun, Liu, Qi-Kun, Wang, Ying-Guang, Wang, Shan-Xi, Lu, Rui, Xu, Hao-Ran, Wan, Jun-Lai, Kang, Hao“…RESULTS: At a mean follow-up of 62.6 months (range, 13–123 months), four patients developed local recurrence, and three developed distant metastases, one of which developed both recurrence and metastasis. The overall survival rate of patients at 5 years was 84.6%, the disease-free survival rate was 69.3%, and the complication rate was 19% (4/21). …”
Publicado 2022
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90320por Chu, Pei-Yi, Huang, Wei-Chieh, Tung, Shiao-Lin, Tsai, Chung-Ying, Chen, Chih Jung, Liu, Yu-Chin, Lee, Chia-Wen, Lin, Yang-Hsiang, Lin, Hung-Yu, Chen, Cheng-Yi, Yeh, Chau-Ting, Lin, Kwang-Huei, Chi, Hsiang-Cheng“…Moreover, we demonstrated ectopic expression of IFITM3 suppressed FOXO3 expression, consequently led to c-MYC induction to promote tumor growth, cell metastasis, cancer stemness as well as chemoresistance. …”
Publicado 2022
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