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90801por He, Jia-Jia, Shang, Lei, Yu, Qun-Wei, Jiao, Ning, Qiu, Shuang, Zhu, Wei-Xiong, Wu, Dong-Feng, Tian, Yun-Er, Zhang, Qing“…Correlation analysis showed that high PPP2R3A expression was correlated with preoperative serum alpha-fetoprotein (AFP) levels (P = 0.003), tumor-node-metastasis-t stage (P ≤ 0.001), and envelope invasion (P = 0.001). …”
Publicado 2021
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90802por Chakiryan, Nicholas H., Kimmel, Gregory J., Kim, Youngchul, Johnson, Joseph O., Clark, Noel, Hajiran, Ali, Chang, Andrew, Aydin, Ahmet M., Zemp, Logan, Katende, Esther, Chahoud, Jad, Ferrall-Fairbanks, Meghan C., Spiess, Philippe E., Francis, Natasha, Fournier, Michelle, Dhillon, Jasreman, Park, Jong Y., Wang, Liang, Mulé, James J., Altrock, Philipp M., Manley, Brandon J.“…CAFs exhibit a pro-tumor effect in vitro and have been implicated in tumor cell proliferation, metastasis, and treatment resistance. Our objective is to analyze the geospatial distribution of CAFs with proliferating and apoptotic tumor cells in the ccRCC tumor microenvironment and determine associations with survival and systemic treatment. …”
Publicado 2021
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90803por Shantha Kumara, HMC, Miyagaki, Hiromichi, Herath, Sajith A, Pettke, Erica, Yan, Xiaohong, Cekic, Vesna, Whelan, Richard L“…These changes may promote residual tumor growth and metastasis.…”
Publicado 2021
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90804por Zhu, Chumeng, Dai, Yuechu, Zhang, Hui, Ruan, Yanyun, Zhou, Yong, Dai, Yingjie, Fan, Lilong, Jia, Tianjun, Lu, Hongsheng, Chen, Qi“…PD-1 showed a significant correlation with PTC lymph node metastasis. CD3(+)PD-1(+) and CD3(+)CD4(+)PD-1(+) was higher in N1 stage than in N0 stage. …”
Publicado 2021
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90805por Yao, Qing, He, Yong-Lai, Wang, Ning, Dong, Shuang-Shuang, Tu He Ta Mi Shi, Mei Er, Feng, Xiao, Chen, Hao, Pang, Li-Juan, Zou, Hong, Zhou, Wen-Hu, Li, Feng, Qi, Yan“…Introduction: Synovial sarcoma (SS) is one of the most invasive soft tissue sarcomas, prone to recurrence and metastasis, and the efficacy of surgical treatment and chemotherapy for SS remains poor. …”
Publicado 2021
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90806“…ANRIL and SOX9 were closely related to tumor grade, tumor diameter, distant metastasis, and family history of glioma (P<0.01). In total, 135 patients were successfully followed up (95.07%). …”
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90807“…BACKGROUND: Not only glycolysis but also lncRNAs play a significant role in the growth, proliferation, invasion and metastasis of of ovarian cancer (OC). However, researches about glycolysis -related lncRNAs (GRLs) remain unclear in OC. …”
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90808por Trastulli, Stefano, Desiderio, Jacopo, Lin, Jian-Xian, Reim, Daniel, Zheng, Chao-Hui, Borghi, Felice, Cianchi, Fabio, Norero, Enrique, Nguyen, Ninh T., Qi, Feng, Coratti, Andrea, Cesari, Maurizio, Bazzocchi, Francesca, Alimoglu, Orhan, Brower, Steven T., Pernazza, Graziano, D’Imporzano, Simone, Azagra, Juan-Santiago, Zhou, Yan-Bing, Cao, Shou-Gen, Garofoli, Eleonora, Mosillo, Claudia, Guerra, Francesco, Liu, Tong, Arcuri, Giacomo, González, Paulina, Staderini, Fabio, Marano, Alessandra, Terrenato, Irene, D’Andrea, Vito, Bracarda, Sergio, Huang, Chang-Ming, Parisi, Amilcare“…SIMPLE SUMMARY: Gastric resection with D2 lymphadenectomy is considered the gold standard for the treatment of both advanced and early gastric cancer with lymph node metastasis. The performance of D2 lymphadenectomy is technically challenging and represents a key factor in improving patients’ survival. …”
Publicado 2021
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90809por Dendl, Katharina, Koerber, Stefan A., Finck, Rebecca, Mokoala, Kgomotso M. G., Staudinger, Fabian, Schillings, Lisa, Heger, Ulrike, Röhrich, Manuel, Kratochwil, Clemens, Sathekge, Mike, Jäger, Dirk, Debus, Jürgen, Haberkorn, Uwe, Giesel, Frederik L.“…RESULTS: In 8 out of 31 patients, the primary tumor was present, and all 31 patients showed lesions suspicious for metastasis (n = 81) demonstrating a high mean SUVmax in both the primary (SUVmax 11.6) and metastatic lesions (SUVmax 9.7). …”
Publicado 2021
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90810“…For clinicopathologic features, dysregulated circRNAs were related to larger tumor size (OR 2.122, 95%CI 1.418–3.175), advanced clinical stage (OR 2.847, 95%CI 2.059–3.935), and present of metastasis (OR 2.630, 95%CI 1.583–4.371). For chemotherapy, dysregulated circRNAs suggest a better response (OR 0.443, 95%CI 0.231–0.849), but a higher probability of resistance (OR 9.343, 95%CI 5.352–16.309). …”
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90811por Khalyfa, Abdelnaby, Trzepizur, Wojciech, Gileles-Hillel, Alex, Qiao, Zhuanhong, Sanz-Rubio, David, Marin, José M., Martinez-Garcia, Miguel A., Campos-Rodriguez, Francisco, Almendros, Isaac, Farre, Ramon, Sanchez-de-la-Torre, Manuel, García-Río, Francisco, Gozal, David“…Exosomes are secreted by most cells, and play a role in OSA-associated tumor progression and metastasis. We aimed to study the effects of plasma exosomes from OSA patients before and after adherent treatment with continuous positive airway pressure (CPAP) on melanoma cells lines, and also to identify exosomal miRNAs from melanoma cells exposed to intermittent hypoxia (IH) or normoxia. …”
Publicado 2021
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90812por Hackeng, Wenzel M, Brosens, Lodewijk A A, Kim, Joo Young, O'Sullivan, Roderick, Sung, You-Na, Liu, Ta-Chiang, Cao, Dengfeng, Heayn, Michelle, Brosnan-Cashman, Jacqueline, An, Soyeon, Morsink, Folkert H M, Heidsma, Charlotte M, Valk, Gerlof D, Vriens, Menno R, Nieveen van Dijkum, Els, Offerhaus, G Johan A, Dreijerink, Koen M A, Zeh, Herbert, Zureikat, Amer H, Hogg, Melissa, Lee, Kenneth, Geller, David, Marsh, J Wallis, Paniccia, Alessandro, Ongchin, Melanie, Pingpank, James F, Bahary, Nathan, Aijazi, Muaz, Brand, Randall, Chennat, Jennifer, Das, Rohit, Fasanella, Kenneth E, Khalid, Asif, McGrath, Kevin, Sarkaria, Savreet, Singh, Harkirat, Slivka, Adam, Nalesnik, Michael, Han, Xiaoli, Nikiforova, Marina N, Lawlor, Rita Teresa, Mafficini, Andrea, Rusev, Boris, Corbo, Vincenzo, Luchini, Claudio, Bersani, Samantha, Pea, Antonio, Cingarlini, Sara, Landoni, Luca, Salvia, Roberto, Milione, Massimo, Milella, Michele, Scarpa, Aldo, Hong, Seung-Mo, Heaphy, Christopher M, Singhi, Aatur D“…RESULTS: ATRX/DAXX loss and ALT were associated with several adverse prognostic findings and distant metastasis/recurrence (p<0.001). The 5-year RFS rates for patients with ATRX/DAXX-negative and ALT-positive NF-PanNETs were 40% and 42% as compared with 85% and 86% for wild-type NF-PanNETs (p<0.001 and p<0.001). …”
Publicado 2022
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90813por Doll, Christian, Bestendonk, Carolin, Kreutzer, Kilian, Neumann, Konrad, Pohrt, Anne, Trzpis, Irena, Koerdt, Steffen, Dommerich, Steffen, Heiland, Max, Raguse, Jan-Dirk, Jöhrens, Korinna“…Sub-group analysis in relation to gender revealed a highly significant influence of ERα expression on OS and RFS in males but not in females, both for the ERα-positive primary tumor cohort (males: p = 0.0013; p < 0.0001; females: p = 0.56; p = 0.89) and the ERα-positive primary tumor/primary lymph node metastasis cohort (males: p < 0.0001; p < 0.0001; females: p = 0.95; p = 0.96). …”
Publicado 2021
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90814por Xia, Tian, Meng, Lian, Zhao, Zhijuan, Li, Yujun, Wen, Hao, Sun, Hao, Zhang, Tiantian, Wei, Jingxian, Li, Feng, Liu, Chunxia“…Gene set enrichment analysis (GSEA) revealed that the genes in MAD2L1 and CCNB2 groups with high expression were mainly related to the mechanism of tumour metastasis and recurrence. In the low-expression MAD2L1 and CCNB2 groups, the genes were enriched in the metabolic and immune pathways. …”
Publicado 2021
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90815por Aghdam, Nima, Lischalk, Jonathan W., Marin, Monica Pernia, Hall, Clare, O’Connor, Timothy, Campbell, Lloyd, Suy, Simeng, Collins, Sean P., Margolis, Marc, Krochmal, Rebecca, Anderson, Eric, Collins, Brian T.“…The Kaplan-Meier method was used to estimate overall survival (OS), local control (LC), regional control (RC), distant metastasis free survival (DMFS) and disease-free survival (DFS). …”
Publicado 2021
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90816por Zheng, Shuo-Han, Liu, Song-Ran, Wang, Hai-Bo, Wei, Ying-Hong, Li, He, Wang, Guan-Nan, Huang, Zi-Lu, Ding, Shi-Rong, Chen, Chen, Tao, Ya-Lan, Li, Xiao-Hui, Glorieux, Christophe, Huang, Peng, Wu, Yang-Feng, Xia, Yun-Fei“…MAIN OUTCOMES AND MEASURES: The main outcomes included overall survival (OS); subsequent-line, treatment-free survival (sTFS), defined as the period from metastasis to the date requiring subsequent-line treatment or death; and the survival to toxicity ratio (STR), defined as person-year rate of OS divided by person-year rate of severe hematologic toxic effects. …”
Publicado 2021
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90817por Huang, Wen-peng, Li, Li-ming, Li, Jing, Yuan, Jun-hui, Hou, Ping, Liu, Chen-chen, Ma, Yi-hui, Liu, Xiao-nan, Han, Yi-jing, Liang, Pan, Gao, Jian-bo“…Between the HAS and non-HAS groups, there were observed differences in terms of: sex, serum alpha-fetoprotein (AFP), carbohydrate antigen (CA)-125, and CA-724 levels; longest tumor diameter; degree of differentiation; vascular invasion; N stage, M stage, and tumor-node-metastasis (TNM) stage; thickest tumor diameter; plain CT attenuation; arterial-phase CT attenuation; CT attenuation between the venous and arterial phases; enhancement modes; and degrees of enhancement (all P < 0.05). …”
Publicado 2021
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90818por Liu, Zhuo, Li, Yuxuan, Zhao, Xun, Ge, Liyuan, Zhu, Guodong, Hong, Peng, Tang, Shiying, Zhang, Shudong, Tian, Xiaojun, Wang, Shumin, Liu, Cheng, Zhang, Hongxian, Ma, Lulin“…Multivariate Cox regression analysis showed that GADVR tumor thrombus, symptoms, postoperative serum creatinine, distant metastasis, sarcomatoid feature, pathological type, lymph node dissection were independent risk factors for PFS. …”
Publicado 2021
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90819por Ma, Ting Martin, Romero, Tahmineh, Nickols, Nicholas G., Rettig, Matthew B., Garraway, Isla P., Roach, Mack, Michalski, Jeff M., Pisansky, Thomas M., Lee, W. Robert, Jones, Christopher U., Rosenthal, Seth A., Wang, Chenyang, Hartman, Holly, Nguyen, Paul L., Feng, Felix Y., Boutros, Paul C., Saigal, Christopher, Chamie, Karim, Jackson, William C., Morgan, Todd M., Mehra, Rohit, Salami, Simpa S., Vince, Randy, Schaeffer, Edward M., Mahal, Brandon A., Dess, Robert T., Steinberg, Michael L., Elashoff, David, Sandler, Howard M., Spratt, Daniel E., Kishan, Amar U.“…Cox proportional hazards models were used to evaluate differences in all-cause mortality and the composite outcome of distant metastasis (DM) or death. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed. …”
Publicado 2021
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90820por Iseas, Soledad, Sendoya, Juan M., Robbio, Juan, Coraglio, Mariana, Kujaruk, Mirta, Mikolaitis, Vanesa, Rizzolo, Mariana, Cabanne, Ana, Ruiz, Gonzalo, Salanova, Rubén, Gualdrini, Ubaldo, Méndez, Guillermo, Antelo, Marina, Carballido, Marcela, Rotondaro, Cecilia, Viglino, Julieta, Eleta, Martín, Di Sibio, Alejandro, Podhajcer, Osvaldo L., Roca, Enrique, Llera, Andrea S., Golubicki, Mariano, Abba, Martín Carlos“…Integrated clinical and molecular-based unsupervised analysis allowed us to identify two RC prognostic groups (cluster 1 and cluster 2) associated with disease-specific OS (HR = 20.64; 95%CI = 2.63–162.2; p <0.0001), metastasis-free survival (HR = 3.67; 95%CI = 1.22–11; p = 0.012), local recurrence-free survival (HR = 3.34; 95%CI = 0.96–11.6; p = 0.043) and worse DFS (HR = 2.68; 95%CI = 1.18–6.06; p = 0.012). …”
Publicado 2022
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