“…Since carbamazepine (CBZ) both stimulates autophagy of misfolded collagen X and improves skeletal pathology in a metaphyseal chondrodysplasia model, we tested the effect of CBZ on bone structure and strength in 3‐week‐old male OI Col1a2 ( +/p.G610C ) and control mice. …”
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“…Common features include thickened wrists and ankles due to widened metaphyses, growth failure, bone pain, muscle weakness, waddling gait, and leg bowing. …”
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“…SFRP4 is critical for metaphyseal bone modeling involved in determining bone width. …”
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“…On rare occasions, they may affect bones, preferentially the metaphyses of the long bone. They are generally asymptomatic and radiography shows radiolucent lesions with a thin sclerotic rim or radiodense lesions with a thick sclerotic rim. …”
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“…Osteogenesis imperfecta IIC (OI IIC), which is a rare variant of lethal OI that has been considered to be an autosomal recessive trait, is characterized by twisted, slender long bones with dense metaphyseal margins. Here, we report a typical case of OI IIC caused by a novel heterozygous mutation in the C-propeptide region of COL1A1. …”
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“…This paper provides an analysis of the epistemology and metaphysics of zero. We develop several constraints and then argue that a satisfactory account of zero can be obtained by integrating (1) an account of numbers as properties of collections, (2) work on the philosophy of absences, and (3) recent work in numerical cognition and ontogenetic studies.…”
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“…Anatomical restoration of volar tilt is a technical challenge in a displaced distal radius fracture with a dorsally angulated fracture pattern accompanied by dorsal metaphyseal comminution. We adopted a reduction technique using a mini-Hohmann retractor, to accomplish the desired volar tilt in a controlled fashion. …”
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“…This volume combines both disciplines for a philosophical interpretation of quantum physics - an interpretation free from the imprecision of metaphysics, offering a view of the atomic world and its quantum mechanical results as concrete as the visible everyday world.Written by an internationally renowned philosopher who specialized in symbolic logic and the theory of relativity, this approach consists of three parts. …”
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“…BACKGROUND: The purpose of this study was to evaluate the outcome of fractures of the distal radius with metaphyseal and diaphyseal involvement treated with fixed angle volar plates. …”
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“…SCI-induced osteoporosis was localised in i) trabecular bone, where metaphyseal bone was more severely affected than epiphyseal bone, and there was a significant reduction in Distal Femoral Trabecular Extent, a new parameter defined here that quantifies how far trabecular bone penetrates in to the marrow cavity, ii) cortical bone, where diaphyseal bone underwent significant lowering of both cortical area and thickness, while distal-metaphyseal bone did not. …”
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“…In Basic Structures of Reality, Colin McGinn deals with questions of metaphysics, epistemology, and philosophy of mind from the vantage point of physics. …”
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“…In the 1950s and 60s, Bohm took a direction unheard of for a professor of theoretical physics: while still researching in physics, working among others with Yakir Aharanov and later Jeffrey Bub, he also spent time studying “metaphysics”—such as Hegel’s dialectics and Indian panpsychism. 50 years on, questions raised about the direction and philosophical assumptions of theoretical physics show that Bohm’s arguments still have contemporary relevance.…”
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“…Chondromyxoid fibroma (CMF) is a rare benign primary tumor which usually affects the metaphyses of the long bone of the lower extremities in childhood and young adults. …”
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“…Osteochondromas are bone exostoses, with the vast majority extending from the metaphyseal region of long bones and are capped by cartilage. …”
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“…Here, we use the tools of metaphysics to describe a classification scheme for stem cells, and to highlight what their inherent diversity means for cancer treatment.…”
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“…A solitary bone cyst (SBC) is a nonneoplastic osseous lesion affecting ≥95% of the metaphyses of long bones such as the proximal humerus and femur. …”
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“…BACKGROUND: Dislocated fracture of the proximal physeal plate of the tibia with or without metaphyseal fragment is rare in children. This unusual fracture classically excludes rupture of the anterior cruciate ligament due to the ligament's stability. …”
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“…Technical considerations and careful preoperative planning are required in patients with achondroplasia given their small skeletal stature, metaphyseal deformities, and ligamentous laxity.…”
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“…We removed the volarly displaced metaphyses and freed FDP and repaired the A2 pulley. …”
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“…RESULTS: The vascular supply and soft tissue anatomy of the fifth metatarsal explains the increased risk of delayed union and non-union in fractures at the metaphyseal-diaphyseal junction. Lawrence and Botte classify proximal fifth metatarsal fractures according to their location: tuberosity avulsion fractures (zone 1), fractures at metaphyseal-diaphyseal junction extending into the fourth-fifth intermetatarsal joint (zone 2) and proximal diaphyseal fractures (zone 3). …”
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