“…The PAP produced by N-deacetylation was the likely cause of the methemoglobinemia and kidney toxicity observed in this, and previous, studies in the pig. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, NQO1-bioactivatable drugs induce methemoglobinemia and hemolytic anemia at high doses. To circumvent this, NQO1-bioactivatable agents have been shown to synergize with PARP1 inhibitors, pyrimidine radiosensitizers, and IR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methylene blue administration to reverse vasoplegia was decided, but unfortunately, Patent Blue V was erroneously administered, resulting in a severe clinical picture of methemoglobinemia and tissue hypoxia. As a therapeutic intervention, CytoSorb hemoadsorption was initiated, and rapid and significant reduction in plasma methemoglobin, accompanied by improved hemodynamics and normalization in plasma lactate levels, was observed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Two (16.7%) infants treated with GTN patch experienced adverse events (i.e., methemoglobinemia) requiring treatment discontinuation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…High nitrate concentrations in drinking water have been linked to methemoglobinemia and, recently, thyroid cancer. With a large proportion of the nation's agriculture grown in California, thyroid cancer linked to nitrate water contamination is of concern. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The main cause in these cases was hemolytic anemia and methemoglobinemia. Reductions in hemoglobin levels during the use of dapsone were seen in 94% of the patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…High levels of nitrate once metabolized to nitrite can interfere with the oxygen-carrying capacity of hemoglobin, resulting in increased methemoglobin and, subsequently, methemoglobinemia (MetHb) if the animal is deprived of significant amounts of oxygen; however, the level of nitrate exposure necessary to induce MetHb in sows is not clearly defined. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…STATEMENT OF THE PROBLEM: Methemoglobinemia is a potentially life-threatening rare medical condition, which refers to an increase in the level of oxidized form of hemoglobin (methemoglobin). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We have previously identified methylene blue, a tricyclic phenothiazine dye approved for clinical use for the treatment of methemoglobinemia and for other medical applications as a small-molecule inhibitor of the protein–protein interaction (PPI) between the spike protein of the SARS-CoV-2 coronavirus and ACE2, the first critical step of the attachment and entry of this coronavirus responsible for the COVID-19 pandemic. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Dapsone (DDS) therapy can frequently lead to hematological side effects, such as methemoglobinemia and DNA damage. In this study, we aim to evaluate the protective effect of racemic alpha lipoic acid (ALA) and its enantiomers on methemoglobin induction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Changes in carboxyhemoglobin and methemoglobin concentrations in arterial blood occur during urologic surgery, although these amplitudes are small when compared with carbon monoxide intoxication and methemoglobinemia. It is likely that organ perfusion and functions are affected by these monoxide gas mediators during urologic surgery.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PCA is a known toxic and carcinogenic compound which may lead to methemoglobinemia in humans. AIM: This study aims to evaluate the precipitate formed on combination of different irrigants, weigh the amount of precipitate formed and to analyze the precipitate for PCA by using thin layer chromatography (TLC), high performance liquid chromatography (HPLC), column chromatography (CC), electron spray ionization mass spectrometry (ESI-MS), Ultraviolet (UV), and nuclear magnetic resonance (1H-NMR and C-13 NMR). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: High levels of nitrate ([Formula: see text]) in drinking water cause methemoglobinemia in infants; however, few studies have examined the potential effects of low-level exposure on fetal growth, and the results have been inconsistent. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, its use has been validated for methemoglobinemia and malaria treatment. In this study, we first evaluated the virucidal activity of methylene blue against influenza virus H1N1 upon different incubation times and in the presence or absence of light activation, and then against SARS-CoV-2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The nitrate concentration level was found high in the vicinity of agricultural areas due to the excessive use of nitrogenous fertilizers and pesticides, and thus the methemoglobinemia patients ratio increased by 14% (48–62% for the year 2012 and 2019, respectively). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Half of these patients developed other complications including acute kidney injury (AKI), disseminated intravascular coagulation, oxalosis, and methemoglobinemia. About 78.6% developed complications within 3 days of starting vitamin C and only one death was reported. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Progressive hypoxemia, methemoglobinemia, and hemolytic anemia occurred following one dose of rasburicase for hyperuricemia. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Blood glucose, potassium, glucose/potassium ratio, platelet/lymphocyte ratio, white blood cell, neutrophil count, lymphocyte count, neutrophil/lymphocyte ratio, systemic immune inflammation index, venous partial pressure of carbon dioxide, carboxyhemoglobin, and methemoglobinemia levels were significantly different between control, delayed neuropsychiatric syndrome (+), and delayed neuropsychiatric syndrome (−) groups (P < .05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There were no clinical symptoms of methemoglobinemia in any patient. DISCUSSION: Although there was no difference in efficacy in this study, the slow rate of parasite, gametocyte and fever clearance indicates that tafenoquine should not be used as monotherapy for radical cure of P. vivax malaria. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…At a hemoglobin of 1.8 g/dl, she received 2 units of polymerized bovine hemoglobin (Hemopure®, Hemoglogin Oxygen Therapeutics LLC, Souderton, PA, USA), repeated several times on subsequent days because of its short half-life. Considerable methemoglobinemia was noted. After subtracting methemoglobin, the hemoglobin rose by 0.4–0.8 g/dl after each 2 units, initially increasing the oxygen binding capacity of the blood by 33%. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso