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  1. 138801
    “…Notably, applying DoE in bioprocess designs increases experimental efficacy and reliability while minimizing experiments, time, and process costs.…”
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    Optimizing the generation of mature bone marrow-derived dendritic cells in vitro: a factorial study design
  2. 138802
    “…Two high-end devices were evaluated and compared in a highly standardized laparoscopic ovariectomy procedure in dogs: The new generation Ligasure Maryland Sealer/Divider (LMSD) with improved atraumatic curved jaw shape for delicate tissue handling and dissection and non-stick nanocoating, and the new-generation Articulating Enseal G2 (AENG2) with several proclaimed features improving surgical performance, including articulation of the forceps tip; improved tissue compression during sealing; unique offset electrode configuration; and specific nanoparticle coating minimizing thermal spread and tissue sticking. Twenty-one client-owned dogs admitted for elective laparoscopic ovariectomy were randomly assigned to one of two groups: ovariectomy using AENG2 on the left ovary and LMSD in the right ovary or vice-versa. …”
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    Comparison of two advanced bipolar tissue sealer/dividers for laparoscopic ovariectomy in dogs: articulating enseal G2 versus Ligasure Maryland device
  3. 138803
    “…Residents’ increasing stress and decreasing frequency in wearing masks and washing hands and keeping distance contribute to increasing risk of infection, residents should increase the frequency of mask-wearing, practice hand hygiene, keep safe distance from others, ensure stable emotional state, minimize psychological stress, providing evidence support for future responses to emerging infectious diseases. …”
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    Quantifying the benefits of healthy lifestyle behaviors and emotional expressivity in lowering the risk of COVID-19 infection: a national survey of Chinese population
  4. 138804
    “…A meticulous preparedness can minimize the severe effects a total IT failure can cause on patient care, staff and the hospital as a whole.…”
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    Resilienz gegen IT-Angriffe an Kliniken: Ergebnisse einer Stabsrahmenübung an einem Universitätsklinikum
  5. 138805
    “…Therefore, thionamides should be discontinued at least 2 days prior to RIUT in order to achieve the designated target dose more precisely and to minimize radiation exposure of organs at risk.…”
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    The influence of thionamides on intra-thyroidal uptake of (131)I during radioiodine-131 treatment of Graves’ disease
  6. 138806
    “…BACKGROUND: Oblique lumbar interbody fusion (OLIF) is an internationally popular minimally invasive technology for the treatment of various lumbar diseases. …”
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    Effect of spinal orthosis on clinical outcomes of patients after oblique lumbar interbody fusion: a randomized controlled trial study protocol
  7. 138807
    “…A more consistent elaboration of strategies to promote the responsible conduct of research is warranted to minimize risk to populations that are vulnerable and express concerns regarding the loss of privacy. …”
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    The Use of Medical Crowdfunding to Mitigate the Personal Costs of Serious Chronic Illness: Scoping Review
  8. 138808
    “…Enrolled participants were randomly assigned to receive emailed access to one of five tailored interactive sites provided by cooperating research partners or to a targeted, minimally interactive ACS site with text, photographs, and graphics providing stage-based quitting advice and peer modeling. …”
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    Comparing Internet Assistance for Smoking Cessation: 13-Month Follow-Up of a Six-Arm Randomized Controlled Trial
  9. 138809
    “…If potent adjuvants are necessary for subunit vaccines to induce broad and durable immune responses, careful, incremental clinical evaluation is warranted to minimize the risk of adverse events. TRIAL REGISTRATION: ClinicalTrials.gov NCT00000886…”
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    Immunization with Cocktail of HIV-Derived Peptides in Montanide ISA-51 Is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity
  10. 138810
    “…Additional research investigating how to best implement online decision aids should be conducted prior to the widespread adoption of such technology so as to maximize the benefits of the technology while minimizing workflow disruptions.…”
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    Perceived Barriers and Facilitators of Using a Web-Based Interactive Decision Aid for Colorectal Cancer Screening in Community Practice Settings: Findings From Focus Groups With Primary Care Clinicians and Medical Office Staff
  11. 138811
    por Eccles, Suzanne A, Aboagye, Eric O, Ali, Simak, Anderson, Annie S, Armes, Jo, Berditchevski, Fedor, Blaydes, Jeremy P, Brennan, Keith, Brown, Nicola J, Bryant, Helen E, Bundred, Nigel J, Burchell, Joy M, Campbell, Anna M, Carroll, Jason S, Clarke, Robert B, Coles, Charlotte E, Cook, Gary JR, Cox, Angela, Curtin, Nicola J, Dekker, Lodewijk V, dos Santos Silva, Isabel, Duffy, Stephen W, Easton, Douglas F, Eccles, Diana M, Edwards, Dylan R, Edwards, Joanne, Evans, D Gareth, Fenlon, Deborah F, Flanagan, James M, Foster, Claire, Gallagher, William M, Garcia-Closas, Montserrat, Gee, Julia M W, Gescher, Andy J, Goh, Vicky, Groves, Ashley M, Harvey, Amanda J, Harvie, Michelle, Hennessy, Bryan T, Hiscox, Stephen, Holen, Ingunn, Howell, Sacha J, Howell, Anthony, Hubbard, Gill, Hulbert-Williams, Nick, Hunter, Myra S, Jasani, Bharat, Jones, Louise J, Key, Timothy J, Kirwan, Cliona C, Kong, Anthony, Kunkler, Ian H, Langdon, Simon P, Leach, Martin O, Mann, David J, Marshall, John F, Martin, Lesley Ann, Martin, Stewart G, Macdougall, Jennifer E, Miles, David W, Miller, William R, Morris, Joanna R, Moss, Sue M, Mullan, Paul, Natrajan, Rachel, O’Connor, James PB, O’Connor, Rosemary, Palmieri, Carlo, Pharoah, Paul D P, Rakha, Emad A, Reed, Elizabeth, Robinson, Simon P, Sahai, Erik, Saxton, John M, Schmid, Peter, Smalley, Matthew J, Speirs, Valerie, Stein, Robert, Stingl, John, Streuli, Charles H, Tutt, Andrew N J, Velikova, Galina, Walker, Rosemary A, Watson, Christine J, Williams, Kaye J, Young, Leonie S, Thompson, Alastair M
    Publicado 2013
    “…RESULTS: The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. …”
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    Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
  12. 138812
    “…CONCLUSIONS: Geocoding error can be minimized when known coordinates are available to test alternative data and methods. …”
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    Accuracy of residential geocoding in the Agricultural Health Study
  13. 138813
    “…Participants wanted apps to support CF self-management with characteristics such as having multiple rather than single functions (eg, simple alarms), being specific to CF, and minimizing user burden. Common themes for desired CF app features were having information at one’s fingertips, automation of disease management activities such as pharmacy refills, integration with smartphones’ technological capabilities, enhancing communication with health care team, and facilitating socialization within the CF community. …”
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    User Preferences and Design Recommendations for an mHealth App to Promote Cystic Fibrosis Self-Management
  14. 138814
    “…In a subset of 300 subjects enrolled at six clinical centers, we are performing flow cytometric analyses of leukocytes from induced sputum, bronchoalveolar lavage (BAL) and peripheral blood. To minimize several sources of variability, we use a “just-in-time” design that permits immediate staining without pre-fixation of samples, followed by centralized analysis on a single instrument. …”
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    Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
  15. 138815
    “…These results suggest that, in swine production, low dietary protein/energy ratio may be useful for reducing feed costs and minimizing the adverse effects of ammonia release into the environment. …”
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    Effects of dietary protein/energy ratio on growth performance, carcass trait, meat quality, and plasma metabolites in pigs of different genotypes
  16. 138816
    “…Hence, P. falciparum-induced activation of AsP38 MAPK in the midgut facilitates parasite infection through a combination of reduced anti-parasite immune defenses and enhanced host protein synthesis and bioenergetics to minimize the impact of infection on the host and to maximize parasite survival, and ultimately, transmission. …”
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    Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection
  17. 138817
    “…There is a need to identify which interventions minimize the frequency and severity of hot flashes and their impact on quality of life. …”
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    Comparison of physical interventions, behavioral interventions, natural health products, and pharmacologics to manage hot flashes in patients with breast or prostate cancer: protocol for a systematic review incorporating network meta-analyses
  18. 138818
    “…BACKGROUND: There is currently a lack of reliable, minimally invasive biomarkers that could predict the extent of alcoholism-induced CNS damage. …”
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    Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain
  19. 138819
    “…Prespecified age subgroups (2–5 years old and 6–17 years old) improved model accuracy minimally. Seventeen metabolites or protein mediators accounted for separation of PICU sepsis and ED sepsis with 95 % confidence. …”
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    Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis
  20. 138820
    “…BACKGROUND: Magnesium was reported to reduce both the anesthetic requirements and the period needed to reach a bi-spectral index value of 60 when used intra-operatively (Br J Anaesth 83:302-20, 1999; Anesth Analg 20:1273-5, 1988; Br J Anaesth 89:594-8, 2002; Anesth Analg 87:206-10, 1998; Br J Anaesth 89:594-8, 2002; Br J Anaesth 94:438-41, 2005) and to minimize the emergence agitation (Anaesthesia 61:1058-63, 2006). …”
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    Effect of magnesium sulphate on bi-spectral index (BIS) values during general anesthesia in children
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