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  1. 138821
    por Bruford, Michael W., Ginja, Catarina, Hoffmann, Irene, Joost, Stéphane, Orozco-terWengel, Pablo, Alberto, Florian J., Amaral, Andreia J., Barbato, Mario, Biscarini, Filippo, Colli, Licia, Costa, Mafalda, Curik, Ino, Duruz, Solange, Ferenčaković, Maja, Fischer, Daniel, Fitak, Robert, Groeneveld, Linn F., Hall, Stephen J. G., Hanotte, Olivier, Hassan, Faiz-ul, Helsen, Philippe, Iacolina, Laura, Kantanen, Juha, Leempoel, Kevin, Lenstra, Johannes A., Ajmone-Marsan, Paolo, Masembe, Charles, Megens, Hendrik-Jan, Miele, Mara, Neuditschko, Markus, Nicolazzi, Ezequiel L., Pompanon, François, Roosen, Jutta, Sevane, Natalia, Smetko, Anamarija, Štambuk, Anamaria, Streeter, Ian, Stucki, Sylvie, Supakorn, China, Telo Da Gama, Luis, Tixier-Boichard, Michèle, Wegmann, Daniel, Zhan, Xiangjiang
    Publicado 2015
    “…By 2020, according to the Convention on Biodiversity's Aichi Target 13, signatories should ensure that “…the genetic diversity of …farmed and domesticated animals and of wild relatives …is maintained, and strategies have been developed and implemented for minimizing genetic erosion and safeguarding their genetic diversity.” …”
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    Prospects and challenges for the conservation of farm animal genomic resources, 2015-2025
  2. 138822
    “…To improve potency and minimize toxicity, ASA ester prodrugs have been developed, in which the carboxylic acid of ASA is masked and ancillary pharmacophores can be incorporated. …”
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    A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties
  3. 138823
    “…We measured trends and correlates of high risk medication prescribing in a subset of the older UK population (community/institutionalized) to inform harm minimization efforts. METHODS: Three cross-sectional samples from primary care electronic clinical records (UK Clinical Practice Research Datalink, CPRD) in fiscal years 2003/04, 2007/08 and 2011/12 were taken. …”
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    Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12
  4. 138824
    “…BACKGROUND: Single-incision laparoscopic surgery (SILS) is an emerging minimally invasive surgery to reduce abdominal incisions. …”
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    A safety study of transumbilical single incision versus conventional laparoscopic surgery for colorectal cancer: study protocol for a randomized controlled trial
  5. 138825
    “…This differentiation system is simple and is reproducible in several hiPSC clones, thereby minimizing clonal variation among hPSC clones. We also established a system for visualizing motor neurons with a lentiviral reporter for HB9 (HB9(e438)::Venus). …”
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    Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells
  6. 138826
    “…Similarly, health authorities should expand periodic inspections at drug rehabilitation centers to guarantee quality service provision and minimize PWIDs’ concerns about violence. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13011-015-0044-z) contains supplementary material, which is available to authorized users.…”
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    Risk of violence in drug rehabilitation centers: perceptions of people who inject drugs in Tijuana, Mexico
  7. 138827
    “…CONCLUSION: Pharmacist supervised intervention through pharmaceutical care program significantly decreased direct healthcare costs of diabetics in test groups compared to control group and hence describes pharmacist’s contribution in minimizing direct healthcare cost burden of patients.…”
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    Does pharmacist-supervised intervention through pharmaceutical care program influence direct healthcare cost burden of newly diagnosed diabetics in a tertiary care teaching hospital in Nepal: a non-clinical randomised controlled trial approach
  8. 138828
    “…Moreover, metformin in combination with sorafenib significantly minimized postoperative recurrence and lung metastasis of HCC in orthotopic mouse model. …”
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    Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models
  9. 138829
    “…For an economically viable process 3HP must be produced at high titer, rate and yield and preferably at low pH to minimize downstream processing costs. RESULTS: Here we describe the metabolic engineering of baker’s yeast Saccharomyces cerevisiae for biosynthesis of 3HP via a malonyl-CoA reductase (MCR)-dependent pathway. …”
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    Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway
  10. 138830
    “…Cells were isolated from the free gingiva using a minimally invasive technique and were magnetically sorted using anti-STRO-1 antibodies. …”
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    Isolation and characterisation of human gingival margin-derived STRO-1/MACS(+) and MACS(−) cell populations
  11. 138831
    “…SGLT2 inhibitors are expected to be effective in patients with insulin resistance and obesity, but it is important to select treatment according to patient background factors that minimizes the risk of adverse events. There have been a limited number of investigations into the relationship between the clinical efficacy (reducing hemoglobin A1c (HbA1c) and body weight (BW)) or safety of SGLT2 inhibitors and patient characteristics. …”
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    Factors Influencing Changes in Hemoglobin A1c and Body Weight During Treatment of Type 2 Diabetes With Ipragliflozin: Interim Analysis of the ASSIGN-K Study
  12. 138832
    por Weiser, Emily L., Lanctot, Richard B., Brown, Stephen C., Alves, José A., Battley, Phil F., Bentzen, Rebecca, Bêty, Joël, Bishop, Mary Anne, Boldenow, Megan, Bollache, Loïc, Casler, Bruce, Christie, Maureen, Coleman, Jonathan T., Conklin, Jesse R., English, Willow B., Gates, H. River, Gilg, Olivier, Giroux, Marie-Andrée, Gosbell, Ken, Hassell, Chris, Helmericks, Jim, Johnson, Andrew, Katrínardóttir, Borgný, Koivula, Kari, Kwon, Eunbi, Lamarre, Jean-Francois, Lang, Johannes, Lank, David B., Lecomte, Nicolas, Liebezeit, Joe, Loverti, Vanessa, McKinnon, Laura, Minton, Clive, Mizrahi, David, Nol, Erica, Pakanen, Veli-Matti, Perz, Johanna, Porter, Ron, Rausch, Jennie, Reneerkens, Jeroen, Rönkä, Nelli, Saalfeld, Sarah, Senner, Nathan, Sittler, Benoît, Smith, Paul A., Sowl, Kristine, Taylor, Audrey, Ward, David H., Yezerinac, Stephen, Sandercock, Brett K.
    Publicado 2016
    “…Future studies could mitigate impacts of tags by reducing protruding parts and minimizing use of additional markers. Investigators could maximize recovery of tags by strategically deploying geolocators on males, previously marked individuals, and successful breeders, though targeting subsets of a population could bias the resulting migratory movement data in some species. …”
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    Effects of geolocators on hatching success, return rates, breeding movements, and change in body mass in 16 species of Arctic-breeding shorebirds
  13. 138833
    “…New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. …”
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    Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema
  14. 138834
    “…Without patient-matched germline data, large germline databases are needed to minimize false positive mutation calling and mitigate ethnic disparities. …”
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    The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine
  15. 138835
    “…The hypoxia-activated prodrug evofosfamide works as a DNA-alkylating agent under these hypoxic conditions, which directly kills hypoxic cancer cells and potentially minimizes resistance to conventional therapy. This drug has shown promising results in several clinical studies when combined with chemotherapy. …”
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    A phase 1 ‘window-of-opportunity’ trial testing evofosfamide (TH-302), a tumour-selective hypoxia-activated cytotoxic prodrug, with preoperative chemoradiotherapy in oesophageal adenocarcinoma patients
  16. 138836
    “…Here we demonstrate the ability to identify CTCs in patients with advanced bladder cancer through a minimally invasive process. This may have the potential to guide checkpoint inhibitor immune therapies that have been established to have activity, often with durable responses, in a proportion of these patients. …”
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    Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients
  17. 138837
    “…To navigate through the complexity of these association networks we mapped candidate genes and metabolites onto metabolic pathways and implemented a shortest path strategy to highlight potential mechanistic links between metabolites and transcripts at colocalized mQTLs and eQTLs. Minimizing the shortest path length drove prioritization of biological validations by gene silencing. …”
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    Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series
  18. 138838
    “…Furthermore, arsenic contaminated rice induced several toxicities in animal model, most of which could be minimized with the food supplementation of Corchorus olitorius leaves. …”
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    Study of arsenic accumulation in rice and evaluation of protective effects of Chorchorus olitorius leaves against arsenic contaminated rice induced toxicities in Wistar albino rats
  19. 138839
    “…Random treatment allocation was performed online using a minimization technique. A planned analysis was performed after 246 progression events. …”
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    Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma: A randomized phase III Intergroup study by EORTC/NCIC-CTG/TROG/MRC-CTU (EORTC 22033-26033)
  20. 138840
    “…Sleep and circadian dysfunctions are prominent correlates of SMI, yet have been minimally studied in ways that reflect the complexity of the sleep problems experienced. …”
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    A transdiagnostic sleep and circadian treatment to improve severe mental illness outcomes in a community setting: study protocol for a randomized controlled trial
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