“…Recent systematic reviews have confirmed the efficacy and safety of EA, and show that this minimally invasive therapy compares favorably to surgical resection in non-randomized studies. …”
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“…Pre-conception optimization of care and counselling in reproductive-aged women with T1D is imperative to minimize complications in pregnancy.…”
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“…During this time the patient’s TSH declined minimally (baseline 1.06 uIU/mL, subsequent values 0.35-0.51uIU/mL, normal 0.6-3.3 uIU/mL) and Free T4 remained within or close to the normal reference range. …”
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“…Methods Children surviving a brain tumor, excluding craniopharyngioma or a pituitary tumor, for minimally two years, in whom BMI at diagnosis of their brain tumor had been recorded were included from a previous cohort study (n=685 of 718). …”
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“…Treatment with R1881 showed a decrease in the PSI (Percent Spliced Inclusion) as compared to obtained in the absence of R1881 or AR-V7. In contrast, AR-V7 minimally induced single exon skipping as compared to vehicle. …”
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“…Both promote weight loss and have favorable effects on cardiovascular outcomes while minimizing hypoglycemic events, however, in some circumstances their combination might result in previously unexpected side effects. …”
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“…Because short stature results from decreased growth plate chondrogenesis, we previously developed a cartilage-targeting single-chain human antibody fragment (CaAb) (1), aiming to deliver therapeutic molecules to the growth plate, thereby increasing treatment efficacy while minimizing adverse effects on other tissues. In the current study, we created fusion proteins of these CaAbs conjugated with insulin-like growth factor-I (IGF-1), an endocrine/paracrine factor which positively regulates chondrogenesis. …”
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“…It is a knowledge‐intensive technology due not only to its own technical complexity, but also to the inherently conflicting nature of maximizing tumor control while minimizing normal organ damage. As IMRT experience and especially the carefully designed clinical plan data are accumulated during the past two decades, a new set of methods commonly termed knowledge‐based planning (KBP) have been developed that aim to improve the quality and efficiency of IMRT planning by learning from the database of past clinical plans. …”
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“…An in-depth investigation of how RDN, a minimally invasive and safe method, reduces the burden of HF is urgently needed. …”
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“…This study investigated whether FE-associated bacteria and selected FE-associated physiological traits were consistent across geographic locations (Republic of Ireland [ROI] [two batches of pigs, ROI1 and ROI2], Northern Ireland [NI], and Austria [AT]), where differences in genetic, dietary, and management factors were minimized. Pigs (n = 369) were ranked, within litter, on divergence in residual feed intake (RFI), and 100 extremes were selected (50 with high RFI and 50 with low RFI) across geographic locations for intestinal microbiota analysis using 16S rRNA amplicon sequencing and examination of FE-associated physiological parameters. …”
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“…CONCLUSIONS: The natural history of MSCC in children is associated to permanent paralysis, sensory loss, and sphincter dysfunction, thus prompt diagnosis and correct management are needed to minimize morbidity. Treatment strategies differed widely among cancer types and study groups in the absence of optimal evidence-based treatment guidelines. …”
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“…We aimed to study psychophysiological response to anticipatory stressor through analysis of heart rate, self-reported anxiety level, and salivary cortisol in healthy young female athletes by minimalizing the effect of confounders. Materials and Methods: A total of 55 females (25 members of the best league for female volleyball players in Poland and 30 sedentary-lifestyle control subjects) in the follicular phase of their menstrual cycle were exposed to mental arithmetic tasks as an experimental imitation of the stressor. …”
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“…All training sessions were supervised by trained instructors to minimize the risk of injury and to ensure that the participants adhered to the training protocol throughout the entire range of motion. …”
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“…Relative to other eukaryotes, loss of evolutionarily-conserved snRNA domains and common sets of spliceosomal proteins point to a more streamlined splicing mechanism, where intron sequences and structures may be functionally compensating for the minimalization of spliceosome components. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12862-019-1488-y) contains supplementary material, which is available to authorized users.…”
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“…BACKGROUND: The optimal dose of rabbit antithymocyte globulin (ATG, ImtixSangstat) minimizing infections without increasing graft-versus-host disease (GVHD) is unknown in T cell-replete, G-CSF-primed haploidentical hematopoietic stem cell transplantation (haplo-HSCT). …”
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“…Optimized model parameters were identified by minimizing the error between predicted and experimentally measured fingertip forces. …”
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“…METHODS: Co-planar volumetric modulated arc therapy (VMAT) plans were produced for virtual spherical targets with 2–8 cm diameters, minimum target dose objectives of 25 Gy, and objectives to minimize normal tissue dose. Five other sets of plans were produced with additional target dose objectives: 1) minimum dose-volume histogram (DVH) objective on 10% of the target 2) minimum dose objective on a sub-structure within the target, and 3–5) minimum generalized equivalent uniform dose (gEUD) objectives assuming three different volume-effect parameters. …”
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“…In this study we investigated if proton-radiotherapy might reduce the dose delivered to the organs at risk and thus minimize the therapy-associated toxicity. METHODS: In this work we compared the dose delivered to the heart, its coronary vessels and valves, the lungs, the thyroid gland and the breast tissue by different volumetric photon plans and a proton plan, all calculated for a dose of 28.8 Gy (EURO-NET-PHL-C2). …”
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“…To improve cancer survivors’ health, custom alcohol interventions and cessation programs should be conducted to minimize alcohol intake for cancer survivors, especially for excessive alcohol drinkers.…”
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“…Molecular profiling of PE represents a minimally invasive approach of detecting tumor driver mutations for clinical decision making, especially when tumor tissues are not available. …”
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