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  1. 141061
    “…Using a C(18) column that minimizes the silanol effect and influence of metals, the quantitative high performance liquid chromatography (HPLC) method for 32 dyes listed in Safety and Technical Standards for Cosmetics (2015 edition) was optimized, and a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) confirmatory method for the dyes was established. …”
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    32种氧化型染料的高效液相色谱定量及高效液相色谱-串联质谱确证方法
  2. 141062
    “…CONCLUSION: We report the largest series of index case patients investigated for ARMC5 with clinical characterization and confirm that ARMC5 pathogenic variants are associated with a more severe phenotype. In order to minimize negative ARMC5 screening, genotyping could be limited to clear bilateral adrenal involvement on imaging and autonomous cortisol secretion, with an optimum yield for routine clinical practice. …”
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    OR12-3 Identification of Predictive Criteria for the Primary Bilateral Macronodular Adrenal Hyperplasia Gene ARMC5: A European Series of 352 Unselected Patients.
  3. 141063
    “…Finally, we propose COX2 as an upstream target for testing the effectiveness of IHT in preventing or minimizing the effects of COVID-19 and other oxygen-related pathological conditions in the future.…”
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    Mimicking Gene–Environment Interaction of Higher Altitude Dwellers by Intermittent Hypoxia Training: COVID-19 Preventive Strategies
  4. 141064
    por Cilento, Vera
    Publicado 2018
    “…The results of the nonlinear beamline optimization for minimizing the IP beam size are presented in the first section of this chapter. …”
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    Optimization of the Beam Size at the Interaction Point of the Accelerator Test Facility 2
  5. 141065
    “…In spite of trends towards early surgical reconstruction to minimize the risk of secondary meniscus and cartilage injuries, long term disruption of knee joint homeostasis and progression to post- traumatic osteoarthritis (PTOA) occurs in 50-90% of patients - a particularly challenging problem in this young cohort. …”
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    Poster 150: Immunophenotyping of Synovial Tissue in Adolescents Undergoing ACL Reconstruction Reveals Distinct Inflammatory Responses to Injury
  6. 141066
    “…Gastroenterologists and patients may have similar goals of maximizing treatment benefit while minimizing risk; however, gastroenterologists may assess the relative importance of risk differently than patients. …”
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    Are Gastroenterologists Less Tolerant of Treatment Risks than Patients? Benefit-Risk Preferences in Crohn's Disease Management
  7. 141067
    “…BACKGROUND: While increases in prescription drug spending have moderated in recent years, drug spending is still a concern among managed care organizations and health plan administrators. In order to minimize cost increases from year to year, many health care plans have shifted more of the cost of medications to the member-consumer. …”
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    Effect on Drug Utilization and Expenditures of a Cost-Share Change From Copayment to Coinsurance
  8. 141068
    “…Thirteen adults with ADH1 were enrolled and encaleret was individually titrated to normalize albumin-corrected calcium (cCa) and minimize hypercalciuria. Encaleret  was well-tolerated with no serious adverse events reported. …”
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    OR23-03 Sustained Normalization Of Mineral Homeostasis In Autosomal Dominant Hypocalcemia Type 1: Results From A Phase 2 Study Over 18 Months Of Encaleret (CLTX-305) Treatment (NCT04581629)
  9. 141069
    “…Safer and targeted therapies are needed to minimize the morbidity and disease burden of drug resistant PsA isolates. …”
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    2891. Nebulized Phage Therapy for Patients with Cystic Fibrosis with Chronic Pseudomonas aeruginosa Pulmonary Infection: A Phase 1b/2a Randomized, Double-Blind, Placebo-Controlled, Multicenter Study
  10. 141070
    “…Carrier proteins were minimally affected in the E(4)/DRSP and E(4)/LNG groups, in comparison with the EE/DRSP group, where a significant increase in sex hormone-binding globulin was observed. …”
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    Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives
  11. 141071
    “…CONCLUSION: Probiotic supplementation during anti-Helicobacter pylori treatment may be effective for improving H. pylori eradication rates, minimizing the incidence of therapy-related adverse events and alleviating most disease-related clinical symptoms. …”
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    Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials
  12. 141072
    “…Slow-freezing allows for freezing to occur at a sufficiently slow rate to permit adequate cellular dehydration while minimizing intracellular ice formation. Vitrification allows the solidification of the cell(s) and of the extracellular milieu into a glass-like state without the formation of ice. …”
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    Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance
  13. 141073
    “…If troponin becomes positive without alternative explanation, myocarditis should be ruled out with cardiac MRI or myocardial biopsy, and patient should be admitted for treatment with high-dose steroids as early intervention may minimize myocardial injury.…”
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    Myocarditis in a patient treated with Nivolumab and PROSTVAC: a case report
  14. 141074
    “…Overall, the best performing methods were MR-ACBOSTON, MR-ACMAXPROB, MR-ACRESOLUTE and MR-ACUCL, ordered alphabetically. These methods all minimized the number of outliers, standard deviation, and average global and local error. …”
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    A multi-centre evaluation of eleven clinically feasible brain PET/MRI attenuation correction techniques using a large cohort of patients
  15. 141075
    “…It was generally observed that a) AMBA-by-ABA-substitution leads to enhanced ligand internalization, b) the extension of the ABA-linker by two additional amino acids (DOTA-Xaa(2)-Xaa(1)-ABA-) provides sufficient linker length to minimize the interaction of the [M(3+)]DOTA-chelate with the receptor, and that c) introduction of a cationic side chain (Xaa(2)) greatly enhances receptor affinity of the constructs, obliterating the necessity for Tyr(1)-iodination of the pentapeptide core to maintain high receptor affinity (such as in [(177)Lu]PentixaTher). …”
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    A new class of PentixaFor- and PentixaTher-based theranostic agents with enhanced CXCR4-targeting efficiency
  16. 141076
    “…Image-based F1 score was chosen to optimize the operating point on the receiver operating characteristics (ROC) curve so as to minimize the number of missed findings and overcalls per image read. …”
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    Comparison of Chest Radiograph Interpretations by Artificial Intelligence Algorithm vs Radiology Residents
  17. 141077
    por Hässler, Signe, Bachelet, Delphine, Duhaze, Julianne, Szely, Natacha, Gleizes, Aude, Hacein-Bey Abina, Salima, Aktas, Orhan, Auer, Michael, Avouac, Jerôme, Birchler, Mary, Bouhnik, Yoram, Brocq, Olivier, Buck-Martin, Dorothea, Cadiot, Guillaume, Carbonnel, Franck, Chowers, Yehuda, Comabella, Manuel, Derfuss, Tobias, De Vries, Niek, Donnellan, Naoimh, Doukani, Abiba, Guger, Michael, Hartung, Hans-Peter, Kubala Havrdova, Eva, Hemmer, Bernhard, Huizinga, Tom, Ingenhoven, Kathleen, Hyldgaard-Jensen, Poul Erik, Jury, Elizabeth C., Khalil, Michael, Kieseier, Bernd, Laurén, Anna, Lindberg, Raija, Loercher, Amy, Maggi, Enrico, Manson, Jessica, Mauri, Claudia, Mohand Oumoussa, Badreddine, Montalban, Xavier, Nachury, Maria, Nytrova, Petra, Richez, Christophe, Ryner, Malin, Sellebjerg, Finn, Sievers, Claudia, Sikkema, Dan, Soubrier, Martin, Tourdot, Sophie, Trang, Caroline, Vultaggio, Alessandra, Warnke, Clemens, Spindeldreher, Sebastian, Dönnes, Pierre, Hickling, Timothy P., Hincelin Mery, Agnès, Allez, Matthieu, Deisenhammer, Florian, Fogdell-Hahn, Anna, Mariette, Xavier, Pallardy, Marc, Broët, Philippe
    Publicado 2020
    “…METHODS AND FINDINGS: The European consortium ABIRISK (Anti-Biopharmaceutical Immunization: prediction and analysis of clinical relevance to minimize the RISK) conducted a clinical and genomic multicohort prospective study of 560 patients with multiple sclerosis (MS, n = 147), rheumatoid arthritis (RA, n = 229), Crohn’s disease (n = 148), or ulcerative colitis (n = 36) treated with 8 different biopharmaceuticals (etanercept, n = 84; infliximab, n = 101; adalimumab, n = 153; interferon [IFN]-beta-1a intramuscularly [IM], n = 38; IFN-beta-1a subcutaneously [SC], n = 68; IFN-beta-1b SC, n = 41; rituximab, n = 31; tocilizumab, n = 44) and followed during the first 12 months of therapy for time to ADA development. …”
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    Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium
  18. 141078
    “…FcγRII (CD32) and FcγRIII (CD16) were not detectable on HUVECs, while FcγRI (CD64) was minimally expressed. A differential modulation of tlr expression was observed: tlr2, tlr3, and tlr4 were upregulated by ATA-ICs and ACA-ICs, while anti-Th/To-ICs resulted in tlr9 upregulation. …”
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    Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis
  19. 141079
    “…Parmi les résidents, 90,9 % (10/11) ont eu une COVID-19 minime, sans oxygène ou hospitalisation, aucun mort. …”
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    Bénéfice de l’ivermectine : de la gale à la COVID-19, un exemple de sérendipité
  20. 141080
    “…The quadriceps activation failure limits the rehabilitation outcomes, especially strength gains that are essential to the return to sport and to minimize the risk for the onset of knee osteoarthritis. …”
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    Persistent quadriceps activation failure reduces in ACL reconstructed patients submitted to strength training based on force steadiness and visual feedback
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