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761por Qin, Yue, Zhou, Mao-Tian, Hu, Ming-Ming, Hu, Yun-Hong, Zhang, Jing, Guo, Lin, Zhong, Bo, Shu, Hong-Bing“…Mediator of IRF3 activation (MITA, also called STING) is an adapter essential for virus-triggered IFN induction pathways. …”
Publicado 2014
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762“…The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. …”
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763Regulatory Mechanism of Endothelin Receptor B in the Cerebral Arteries after Focal Cerebral Ischemia“…Similar observations were made in MCAO rats. Treatment with MitA, a Sp1 specific inhibitor, significantly downregulated the ET(B)R mRNA and protein levels. …”
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764por Linke, Charlotte, Freitag, Thomas, Riess, Christin, Scheffler, Jana Vanessa, del Moral, Katharina, Schoenwaelder, Nina, Fiedler, Tomas, Fiebig, Adina, Kaps, Philipp, Dubinski, Daniel, Schneider, Björn, Bergmann, Wendy, Classen, Carl Friedrich, Maletzki, Claudia“…METHODS: In this study, we combined the antineoplastic antibiotic Mithramycin A (MitA) with SpyADI to boost single-agent activity and analyzed underlying response mechanisms in-depth. …”
Publicado 2023
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765
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766por Blanton, Michael R., Bershady, Matthew A., Abolfathi, Bela, Albareti, Franco D., Allende Prieto, Carlos, Almeida, Andres, Alonso-García, Javier, Anders, Friedrich, Anderson, Scott F., Andrews, Brett, Aquino-Ortíz, Erik, Aragón-Salamanca, Alfonso, Argudo-Fernández, Maria, Armengaud, Eric, Aubourg, Eric, Avila-Reese, Vladimir, Badenes, Carles, Bailey, Stephen, Barger, Kathleen A., Barrera-Ballesteros, Jorge, Bartosz, Curtis, Bates, Dominic, Baumgarten, Falk, Bautista, Julian, Beaton, Rachael, Beers, Timothy C., Belfiore, Francesco, Bender, Chad F., Berlind, Andreas A., Bernardi, Mariangela, Beutler, Florian, Bird, Jonathan C., Bizyaev, Dmitry, Blanc, Guillermo A., Blomqvist, Michael, Bolton, Adam S., Boquien, Médéric, Borissova, Jura, van den Bosch, Remco, Bovy, Jo, Brandt, William N., Brinkmann, Jonathan, Brownstein, Joel R., Bundy, Kevin, Burgasser, Adam J., Burtin, Etienne, Busca, Nicolás G., Cappellari, Michele, Carigi, Maria Leticia Delgado, Carlberg, Joleen K., Carnero Rosell, Aurelio, Carrera, Ricardo, Cherinka, Brian, Cheung, Edmond, Chew, Yilen Gómez Maqueo, Chiappini, Cristina, Choi, Peter Doohyun, Chojnowski, Drew, Chuang, Chia-Hsun, Chung, Haeun, Cirolini, Rafael Fernando, Clerc, Nicolas, Cohen, Roger E., Comparat, Johan, da Costa, Luiz, Cousinou, Marie-Claude, Covey, Kevin, Crane, Jeffrey D., Croft, Rupert A. C., Cruz-Gonzalez, Irene, Cuadra, Daniel Garrido, Cunha, Katia, Damke, Guillermo J., Darling, Jeremy, Davies, Roger, Dawson, Kyle, de la Macorra, Axel, De Lee, Nathan, Delubac, Timothée, Di Mille, Francesco, Diamond-Stanic, Aleks, Cano-Díaz, Mariana, Donor, John, Downes, Juan José, Drory, Niv, Bourboux, Hélion du Mas des, Duckworth, Christopher J., Dwelly, Tom, Dyer, Jamie, Ebelke, Garrett, Eisenstein, Daniel J., Emsellem, Eric, Eracleous, Mike, Escoffier, Stephanie, Evans, Michael L., Fan, Xiaohui, Fernández-Alvar, Emma, Fernandez-Trincado, J.G., Feuillet, Diane K., Finoguenov, Alexis, Fleming, Scott W., Font-Ribera, Andreu, Fredrickson, Alexander, Freischlad, Gordon, Frinchaboy, Peter M., Galbany, Lluís, Garcia-Dias, R., García-Hernández, D.A., Gaulme, Patrick, Geisler, Doug, Gelfand, Joseph D., Gil-Marín, Héctor, Gillespie, Bruce A., Goddard, Daniel, Gonzalez-Perez, Violeta, Grabowski, Kathleen, Green, Paul J., Grier, Catherine J., Gunn, James E., Guo, Hong, Guy, Julien, Hagen, Alex, Hahn, ChangHoon, Hall, Matthew, Harding, Paul, Hasselquist, Sten, Hawley, Suzanne L., Hearty, Fred, Hernández, Jonay I. Gonzalez, Ho, Shirley, Hogg, David W., Holley-Bockelmann, Kelly, Holtzman, Jon A., Holzer, Parker H., Huehnerhoff, Joseph, Hutchinson, Timothy A., Hwang, Ho Seong, Ibarra-Medel, Héctor J., Ilha, Gabriele da Silva, Ivans, Inese I., Ivory, KeShawn, Jackson, Kelly, Jensen, Trey W., Johnson, Jennifer A., Jones, Amy, Jönsson, Henrik, Jullo, Eric, Kamble, Vikrant, Kinemuchi, Karen, Kirkby, David, Kitaura, Francisco-Shu, Klaene, Mark, Knapp, Gillian R., Kneib, Jean-Paul, Kollmeier, Juna A., Lacerna, Ivan, Lane, Richard R., Lang, Dustin, Law, David R., Lazarz, Daniel, Le Goff, Jean-Marc, Liang, Fu-Heng, Li, Cheng, LI, Hongyu, Lima, Marcos, Lin, Lihwai, Lin, Yen-Ting, de Lis, Sara Bertran, Liu, Chao, Lizaola, Miguel Angel C. de Icaza, Long, Dan, Lucatello, Sara, Lundgren, Britt, MacDonald, Nicholas K., Machado, Alice Deconto, MacLeod, Chelsea L., Mahadevan, Suvrath, Maia, Marcio Antonio Geimba, Maiolino, Roberto, Majewski, Steven R., Malanushenko, Elena, Malanushenko, Viktor, Manchado, Arturo, Mao, Shude, Maraston, Claudia, Marques-Chaves, Rui, Masters, Karen L., McBride, Cameron K., McDermid, Richard M., McGrath, Brianne, McGreer, Ian D., Peña, Nicolás Medina, Melendez, Matthew, Merloni, Andrea, Merrifield, Michael R., Meszaros, Szabolcs, Meza, Andres, Minchev, Ivan, Minniti, Dante, Miyaji, Takamitsu, More, Surhud, Mulchaey, John, Müller-Sánchez, Francisco, Muna, Demitri, Munoz, Ricardo R., Myers, Adam D., Nair, Preethi, Nandra, Kirpal, Nascimento, Janaina Correa do, Negrete, Alenka, Ness, Melissa, Newman, Jeffrey A., Nichol, Robert C., Nidever, David L., Nitschelm, Christian, Ntelis, Pierros, O'Connell, Julia E., Oelkers, Ryan J., Oravetz, Audrey, Oravetz, Daniel, Pace, Zach, Padilla, Nelson, Palanque-Delabrouille, Nathalie, Palicio, Pedro Alonso, Pan, Kaike, Parikh, Taniya, Pâris, Isabelle, Park, Changbom, Patten, Alim Y., Peirani, Sebastien, Pellejero-Ibanez, Marcos, Penny, Samantha, Percival, Will J., Perez-Fournon, Ismael, Petitjean, Patrick, Pieri, Matthew M., Pinsonneault, Marc, Pisani, Alice, Poleski, Radosław, Prada, Francisco, Prakash, Abhishek, Queiroz, Anna Bárbara de Andrade, Raddick, M. Jordan, Raichoor, Anand, Rembold, Sandro Barboza, Richstein, Hannah, Riffel, Rogemar A., Riffel, Rogério, Rix, Hans-Walter, Robin, Annie C., Rockosi, Constance M., Rodríguez-Torres, Sergio, Roman-Lopes, A., Román-Zúñiga, Carlos, Rosado, Margarita, Ross, Ashley J., Rossi, Graziano, Ruan, John, Ruggeri, Rossana, Rykoff, Eli S., Salazar-Albornoz, Salvador, Salvato, Mara, Sánchez, Ariel G., Aguado, David Sánchez, Sánchez-Gallego, José R., Santana, Felipe A., Santiago, Basílio Xavier, Sayres, Conor, Schiavon, Ricardo P., Schimoia, Jaderson da Silva, Schlafly, Edward F., Schlegel, David J., Schneider, Donald P., Schultheis, Mathias, Schuster, William J., Schwope, Axel, Seo, Hee-Jong, Shao, Zhengyi, Shen, Shiyin, Shetrone, Matthew, Shull, Michael, Simon, Joshua D., Skinner, Danielle, Skrutskie, M.F., Slosar, Anže, Smith, Verne V., Sobeck, Jennifer S., Sobreira, Flavia, Somers, Garrett, Souto, Diogo, Stark, David V., Stassun, Keivan, Stauffer, Fritz, Steinmetz, Matthias, Storchi-Bergmann, Thaisa, Streblyanska, Alina, Stringfellow, Guy S., Suárez, Genaro, Sun, Jing, Suzuki, Nao, Szigeti, Laszlo, Taghizadeh-Popp, Manuchehr, Tang, Baitian, Tao, Charling, Tayar, Jamie, Tembe, Mita, Teske, Johanna, Thakar, Aniruddha R., Thomas, Daniel, Thompson, Benjamin A., Tinker, Jeremy L., Tissera, Patricia, Tojeiro, Rita, Toledo, Hector Hernandez, de la Torre, Sylvain, Tremonti, Christy, Troup, Nicholas W., Valenzuela, Octavio, Valpuesta, Inma Martinez, Vargas-González, Jaime, Vargas-Magaña, Mariana, Vazquez, Jose Alberto, Villanova, Sandro, Vivek, M., Vogt, Nicole, Wake, David, Walterbos, Rene, Wang, Yuting, Weaver, Benjamin Alan, Weijmans, Anne-Marie, Weinberg, David H., Westfall, Kyle B., Whelan, David G., Wild, Vivienne, Wilson, John, Wood-Vasey, W.M., Wylezalek, Dominika, Xiao, Ting, Yan, Renbin, Yang, Meng, Ybarra, Jason E., Yèche, Christophe, Zakamska, Nadia, Zamora, Olga, Zarrouk, Pauline, Zasowski, Gail, Zhang, Kai, Zhao, Gong-Bo, Zheng, Zheng, Zhou, Zhi-Min, Zhu, Guangtun B., Zoccali, Manuela, Zou, HuEnlace del recurso
Publicado 2017
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767
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768por Zheng, Zhou-Qin, Fu, Yu-Zhi, Wang, Su-Yun, Xu, Zhi-Sheng, Zou, Hong-Mei, Wang, Yan-Yi“…After herpes simplex virus type 1 (HSV-1) infection, the cytosolic sensor cyclic GMP-AMP synthase (cGAS) recognizes DNA and catalyzes synthesis of the second messenger 2′3′-cGAMP. cGAMP binds to the ER-localized adaptor protein MITA (also known as STING) to activate downstream antiviral responses. …”
Publicado 2022
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769por Tong, Jin-Feng, Zhou, Li, Li, Shun, Lu, Long-Feng, Li, Zhuo-Cong, Li, Zhi, Gan, Rui-Hai, Mou, Cheng-Yan, Zhang, Qi-Ya, Wang, Zhong-Wei, Zhang, Xiao-Juan, Wang, Yang, Gui, Jian-Fang“…Finally, we demonstrated that CgSHP1-A (encoded by the Cgptpn6-A gene) and CgSHP1-B (encoded by the Cgptpn6-B gene) act as negative regulators of the RIG-I-like receptor (RLR)-mediated interferon (IFN) response via two mechanisms: the inhibition of CaTBK1-induced phosphorylation of CaMITA shared by CgSHP1-A and CgSHP1-B, and the autophagic degradation of CaMITA exclusively by CgSHP1-A. …”
Publicado 2021
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770por Jin, Lei, Xu, Liang-guo, Yang, Ivana V., Davidson, Elizabeth J., Schwartz, David A., Wurfel, Mark M., Cambier, John C.“…MPYS, also known as STING and MITA, is an IFNβ stimulator essential for host defense against RNA, DNA viruses and intracellular bacteria. …”
Publicado 2011
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771por Li, Zexing, Liu, Ge, Sun, Liwei, Teng, Yan, Guo, Xuejiang, Jia, Jianhang, Sha, Jiahao, Yang, Xiao, Chen, Dahua, Sun, Qinmiao“…Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. …”
Publicado 2015
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772por Wang, Xiao, Scarfò, Irene, Schmidts, Andrea, Toner, Mehmet, Maus, Marcela V., Irimia, Daniel“…Here, a micropatterned tumor array (MiTA) is described that enables detailed and dynamic characterization of CAR T cell trafficking toward tumor‐cell islands and subsequent killing of tumor cells. …”
Publicado 2019
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773por Apostolakis, Alcibiades J, Aslanides, Elie, Backenstoss, Gerhard, Bargassa, P, Behnke, O, Benelli, A, Bertin, V, Blanc, F, Bloch, P, Carlson, P J, Carroll, M, Cawley, E, Chertok, M B, Danielsson, M, Dejardin, M, Derré, J, Ealet, A, Eleftheriadis, C, Fetscher, W, Fidecaro, Maria, Filipcic, A, Francis, D, Fry, J, Gabathuler, Erwin, Gamet, R, Gerber, H J, Go, A, Haselden, A, Hayman, P J, Henry-Coüannier, F, Hollander, R W, Jon-And, K, Kettle, P R, Kokkas, P, Kreuger, R, Le Gac, R, Leimgruber, F, Mandic, I, Manthos, N, Marel, Gérard, Mikuz, M, Miller, J, Montanet, François, Müller, A, Nakada, Tatsuya, Pagels, B, Papadopoulos, I M, Pavlopoulos, P, Polivka, G, Rickenbach, R, Roberts, B L, Ruf, T, Sakelliou, L, Schäfer, M, Schaller, L A, Schietinger, T, Schopper, A, Tauscher, Ludwig, Thibault, C, Touchard, F, Touramanis, C, van Eijk, C W E, Vlachos, S, Weber, P, Wigger, O, Wolter, M, Yéche, C, Zavrtanik, D, Zimmerman, D“…With $\dm = (530.1 \pm 1.4) \times 10^{7}\hbar s^{-1}$ and $\ts = (89.32 \pm 0.08)$ ps, the values obtained are $\mita = (2.264 \pm 0.023_\mathrm{{stat}} \pm 0.026_\mathrm{{syst}} \pm 0.007_{\ts}) \times 10^{-3}$ and $\fas = 43.19^{\circ} \pm 0.53^{\circ}_\mathrm{{st at}} \pm 0.28^{\circ}_\mathrm{{syst}} \pm 0.42^{\circ}_{\dm}$.…”
Publicado 1999
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774por Chen, Wei, Li, Senlin, Yu, Huansha, Liu, Xing, Huang, Lulu, Wang, Qiang, Liu, Heng, Cui, Ye, Tang, Yijun, Zhang, Peng, Wang, Chen“…Stimulator of interferon genes (STING, also known as MITA, ERIS or MPYS) induces the activation of TBK1 kinase and IRF3 transcription factor, upon sensing of microbial DNAs. …”
Publicado 2016
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775por Huang, Zhiqing, Chen, Xiaoling, Zhang, Keying, Yu, Bing, Mao, Xiangbing, Zhao, Ye, Chen, Daiwen“…Stimulator of interferon (IFN) genes (STING), also known as MPYS/MITA/ERIS/TMEM173, is an adaptor that functions downstream of RIG-I and MAVS and upstream of TBK1 and plays a critical role in type I IFN induction. …”
Publicado 2012
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776por Blaauboer, Steven M, Mansouri, Samira, Tucker, Heidi R, Wang, Hatti L, Gabrielle, Vincent D, Jin, Lei“…The enhancement depends on MPYS (STING, MITA) expression in CD11C(+) cells. Second, we found that CDG selectively activated pinocytosis-efficient-DCs, leading to T(H) polarizing cytokines IL-12p70, IFNγ, IL-5, IL-13, IL-23, and IL-6 production in vivo. …”
Publicado 2015
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777por Sun, He, Zhang, Qiang, Jing, Ying-Ying, Zhang, Man, Wang, Hai-Ying, Cai, Zeng, Liuyu, Tianzi, Zhang, Zhi-Dong, Xiong, Tian-Chen, Wu, Yan, Zhu, Qi-Yun, Yao, Jing, Shu, Hong-Bing, Lin, Dandan, Zhong, Bo“…STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. …”
Publicado 2017
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778“…METHODS: This retrospective study collected information from the medical records of 117 patients who underwent laparotomy between December 1, 2019, and October 13, 2020, at the Department of Gastroenterology of the International University of Health and Welfare Mita Hospital. Based on the failure or success of the ambulation process, the patients were divided into the delayed and successful groups, respectively. …”
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779“…Further studies revealed that SPI-2 and CrmA associated with TBK1 and IKKε to disrupt the MITA-TBK1/IKKε-IRF3 complex. These findings reveal a novel mechanism of SPI-2/CrmA-mediated poxvirus immune evasion.…”
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780por Cheng, Zhangliang, Dai, Tong, He, Xuelin, Zhang, Zhengkui, Xie, Feng, Wang, Shuai, Zhang, Long, Zhou, Fangfang“…The cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) detects DNA and then mediates downstream immune responses through the molecule stimulator of interferon genes (STING, also known as MITA, MPYS, ERIS and TMEM173). Recent studies focusing on the roles of the cGAS-STING pathway in evolutionary distant species have partly sketched how the mammalian cGAS-STING pathways are shaped and have revealed its evolutionarily conserved mechanism in combating pathogens. …”
Publicado 2020
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