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  1. 1
    por Zhong, Li, Shu, Hong-Bing
    Publicado 2021
    “…How the cGAS‒MITA/STING axis is inactivated upon nuclear envelope breakdown (NEBD) at mitotic entry in vertebrate cells to avoid self-DNA sensing remains unclear until very recently. …”
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    Mitotic inactivation of the cGAS‒MITA/STING pathways
  2. 2
    por Zhang, Zhi-Dong, Zhong, Bo
    Publicado 2022
    “…Here, we summarize the identification and activation of cGAS and MITA/STING, present the updated functions and regulatory mechanisms of cGAS-MITA/STING signaling and provide a comprehensive understanding of the cGAS-MITA/STING axis in autoimmune diseases and cancers.…”
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    Regulation and function of the cGAS-MITA/STING axis in health and disease
  3. 3
    por Ran, Yong, Shu, Hong-Bing, Wang, Yan-Yi
    Publicado 2014
    “…Many studies have established that MITA/STING is a central component in the innate immune response to cytosolic DNA and RNA derived from pathogens. …”
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    MITA/STING: A central and multifaceted mediator in innate immune response
  4. 4
    “…The cleavage site of MITA was mapped to LRR↓(96)G and the function of MITA was suppressed by dengue protease. …”
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    Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity
  5. 5
    “…Mediator of IRF3 activation (MITA, also named as STING/ERIS/MPYS/TMEM173), is essential to DNA virus- or cytosolic DNA-triggered innate immune responses. …”
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    RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation
  6. 6
    “…The mediator of IRF3 activation (MITA, also named STING) is critical for immune responses to abnormal cytosolic DNA and has been considered an important drug target in the clinical therapy of tumors and autoimmune diseases. …”
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    MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST
  7. 7
    “…Previously, we identified an alternatively spliced isoform of MITA/STING, called MITA-related protein (MRP), and found that MRP could specifically block MITA-mediated interferon (IFN) induction while retaining the ability to activate NF-κB. …”
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    MITA/STING and Its Alternative Splicing Isoform MRP Restrict Hepatitis B Virus Replication
  8. 8
    “…MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic DNA. …”
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    SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA
  9. 9
    “…In this study, we identified the deubiquitinating enzyme USP44 as a positive regulator of MITA. USP44 is recruited to MITA following DNA virus infection and removes K48-linked polyubiquitin moieties from MITA at K236, therefore prevents MITA from proteasome mediated degradation. …”
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    USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA
  10. 10
    por Mita, Munesuke, 1937-
    Publicado 1996
    Libro
    Psicología social del Japón moderno
  11. 11
    “…MITA (also called STING), a master regulator of DNA-mediated innate immune activation, is a potential therapeutic target for viral infection and virus-related diseases. …”
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    MITA Promotes Macrophage Proinflammatory Polarization and Its circRNA-Related Regulatory Mechanism in Recurrent Miscarriage
  12. 12
    “…Hence, the Multidimensional Intercultural Training Acculturation (MITA) model is introduced. The model proposes that two major concerns for adolescent refugees, which are socio-cultural adjustment and mental health, are predicted by intercultural and social–emotional competence, intentions to return to their homeland, and experiences of traumatic events. …”
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    A Brief Introduction to the Multidimensional Intercultural Training Acculturation Model (MITA) for Middle Eastern Adolescent Refugees
  13. 13
    “…UL42 also impairs translocation of MITA from the ER to perinuclear punctate structures, which is required for MITA activation, by facilitating p62/LC3B-mediated degradation of translocon-associated protein β (TRAPβ). …”
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    Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response
  14. 14
    “…MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. …”
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    RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA
  15. 15
    “…Specifically, we observed that TRIM38-mediated K48 ubiquitination of MITA was higher in M2 macrophages, leading to low expression levels of MITA and thus inhibiting pyroptosis. …”
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    Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface
  16. 16
    “…The activity of MITA is critically regulated by ubiquitination and deubiquitination. …”
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    USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
  17. 17
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    Manga cho himo riron o papa ni naratte mita: tensai butsurigakusha naniwazaka kyoju no nanajippun kogi
  18. 18
    por Morales Chanona, Pedro
    Publicado 1995
    Libro
    Proceso de fotocopiado en blanco y negro para las máquinas de fotocopiado de la industria Mita
  19. 19
    “…MITAS creates tables and graphs representing the mixture risk for an applied spray series time-dependently. • A simulation of the impact of application series for a period of up to three years is possible with MITAS. …”
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    MITAS: A model for assessing the time-dependent risk of sequential applications of pesticides for soil organisms by consideration of exposure, degradation and mixture toxicity
  20. 20
    “…MITA is regulated by post-translational modifications, but how post-transcriptional mechanisms are involved in the regulation of MITA is still largely unknown. …”
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    The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response
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