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  1. 147621
    “…The stability of these drugs in complex with GT-4a was investigated by using energetic and structural analyses over MD simulations. The Prime MM-GBSA (molecular mechanics/generalized Born surface area) method was used as a validation tool after the docking stage and for the averaged clusters after the MD simulation stage. …”
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    Studies of the symmetric binding mode of daclatasvir and analogs using a new homology model of HCV NS5A GT-4a
  2. 147622
    por Inoue, Gen, Miyagi, Masayuki, Saito, Wataru, Shirasawa, Eiki, Uchida, Kentaro, Hosogane, Naobumi, Watanabe, Kei, Katsumi, Keiichi, Kaito, Takashi, Yamashita, Tomoya, Fujiwara, Hiroyasu, Nagamoto, Yukitaka, Nojiri, Kenya, Suzuki, Satoshi, Okada, Eijiro, Ueda, Seiji, Hikata, Tomohiro, Shiono, Yuta, Watanabe, Kota, Terai, Hidetomi, Tamai, Koji, Matsuoka, Yuji, Suzuki, Hidekazu, Nishimura, Hirosuke, Tagami, Atsushi, Yamada, Shuta, Adachi, Shinji, Ohtori, Seiji, Furuya, Takeo, Orita, Sumihisa, Inage, Kazuhide, Yoshii, Toshitaka, Ushio, Shuta, Funao, Haruki, Isogai, Norihiro, Harimaya, Katsumi, Okada, Seiji, Kawaguchi, Kenichi, Yokoyama, Nobuhiko, Oishi, Hidekazu, Doi, Toshio, Kiyasu, Katsuhito, Imagama, Shiro, Ando, Kei, Kobayashi, Kazuyoshi, Sakai, Daisuke, Tanaka, Masahiro, Kimura, Atsushi, Inoue, Hirokazu, Nakano, Atsushi, Ikegami, Shota, Shimizu, Masayuki, Futatsugi, Toshimasa, Kakutani, Kenichiro, Yurube, Takashi, Nakanishi, Kazuyoshi, Oshima, Masashi, Uei, Hiroshi, Aoki, Yasuchika, Takahata, Masahiko, Iwata, Akira, Endo, Hirooki, Seki, Shoji, Murakami, Hideki, Kato, Satoshi, Yoshioka, Katsuhito, Hongo, Michio, Abe, Tetsuya, Tsukanishi, Toshinori, Takaso, Masashi, Ishii, Ken
    Publicado 2022
    “…Improvement in the visual analogue scale for leg pain was significantly less in the low BMI group than the high BMI group (26.7 vs 42.8 mm; P = .046). Radiological evaluation, the Frankel classification, and postoperative complications were not significantly different among all 3 groups. …”
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    Effect of low body mass index on clinical recovery after fusion surgery for osteoporotic vertebral fracture: A retrospective, multicenter study of 237 cases
  3. 147623
    “…CRP (> 73.1 mg/L), O(2) saturation variation (greater than 90%, 84–90%, and less than 84%), increased PT (> 16.2 s), diastolic blood pressure (≤ 75 mmHg), BUN (> 23 mg/dL), and raised LDH (> 731 U/L) were the features constituting the scoring system. …”
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    A novel scoring system for early assessment of the risk of the COVID-19-associated mortality in hospitalized patients: COVID-19 BURDEN
  4. 147624
    “…Median CD4 count was 614/mm(3) and 24.6% of the patients had a history of previous virological failure. …”
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    Safety and efficacy of switching to elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate in treatment-experienced people with HIV: a multicenter cohort study
  5. 147625
    “…The OKS scores for the JII-BCS and Genesis II groups were mean (SD) 42.97 (5.21) and 43.13 (5.20) respectively, adjusted effect size 0.35 (-2.01,2.71) p=0.771 In secondary outcome measures, the Genesis II group demonstrated a significantly greater walking range-of-movement (50.62 (7.33) vs 46.07 (7.71) degrees, adjusted effect size, 3.14 (0.61,5.68) p=0.02) and higher peak knee flexion angular velocity during walking (mean (SD) 307.69 (38.96) vs 330.38 (41.40) degrees/second, adjusted effect size was 21.75 (4.54,38.96), p=0.01) and better postural control (smaller resultant centre of path length) during quiet standing than the JII-BCS group (mean (SD) 158.14 (65.40) vs 235.48 (176.94) mm, adjusted effect size, 59.91 (–105.98, –13.85) p=0.01.). …”
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    Comparison of the Journey II bicruciate stabilised (JII-BCS) and GENESIS II total knee arthroplasty for functional ability and motor impairment: the CAPAbility, blinded, randomised controlled trial
  6. 147626
    “…Results: A “minimum bladder” contour, the overlap between the original bladder contour and a 15 mm anterior and superior expansion from prostate bed PTV, was confirmed to be effective in identifying cases that might fail a bladder constraint of V65% <60%. …”
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    Clinical Practice Evolvement for Post-Operative Prostate Cancer Radiotherapy—Part 1: Consistent Organs at Risk Management with Advanced Image Guidance
  7. 147627
    “…One Flare (Micro Mega, Besançon, France) was introduced 4 mm below the canal entrance for canals prepared with coronal flaring. …”
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    Influence of Coronal Flaring on the Shaping Ability of Two Heat-Treated Nickel-Titanium Endodontic Files: A Micro-Computed Tomographic Study
  8. 147628
    “…Although group 1 exhibited no significant improvement in CRF at group level, a significant decrease in diastolic blood pressure (70.4 ± 7.8 vs 68.7 ± 7.2 mm Hg, P = 0.027) was observed. CONCLUSIONS: Unsupervised learning based on dense phenotypic characteristics identified meaningful subgroups within a healthy population with different CRF responses following standardized aerobic training. …”
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    Unsupervised cluster analysis reveals distinct subgroups in healthy population with different exercise responses of cardiorespiratory fitness
  9. 147629
    “…RESULTS: After adjusting for age, gender and BMI, subjects in I tertile showed a decrease in myocardial MEEi (0.31 ± 0.05 vs 0.42 ± 0.14 ml/s*g, P = 0.02), and an increase in myocardial oxygen consumption (MVO(2)) (10,153 ± 1375 vs 7816 ± 1229 mmHg*bpm, P < 0.0001) as compared with subjects in III tertile. …”
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    Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance
  10. 147630
    “…The changes in the mechanics of the myocardium of normal wall thickness (< 12 mm) have yet to be well studied. This study aimed to evaluate the function of myocardial segments of normal thickness in patients with HCM. …”
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    Diastolic dysfunction assessed by cardiac magnetic resonance imaging tissue tracking on normal-thickness wall segments in hypertrophic cardiomyopathy
  11. 147631
    “…While multiple periodontal risk factors were assessed, we used periodontal pocket depth of 3 mm to characterise periodontal risk. As periodontal pocket depth confounded the analysis of familial history of hyperlipidaemia, a multivariate analyses were performed (i.e., no periodontal risk markers in children with or without a family history of hyperlipidaemia were compared to counterparts who did not have periodontal risk markers) to examine linkages between these factors and diversity and composition of the microbiome. …”
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    Type 1 diabetes, periodontal health, and a familial history of hyperlipidaemia is associated with oral microbiota in children: a cross-sectional study
  12. 147632
    “…The mean values of NIKBUT first and NIKBUT average increased significantly after treatment (from 5.29 ± 2.60 at T0 to 9.04 ± 3.49 s at T1 [P = 0.001] and from 9.40 ± 3.81 to 11.28 ± 2.81 s [P = 0.017]); in parallel, the mean value of TMH increased significantly from 0.27 ± 0.06 to 0.32 ± 0.09 mm (P = 0.029). Conversely, there were not statistically significant differences for MGL (P = 0.346). …”
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    Serial Sessions of a Novel Low-Level Light Therapy Device for Home Treatment of Dry Eye Disease
  13. 147633
    “…White cell count was >30,000 per mm(3) in 26% of patients, while 13% had additional cytogenetic abnormalities. …”
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    Outcomes of Philadelphia Positive Acute Lymphoblastic Leukemia in Adolescent and Young Adults
  14. 147634
    “…The lateral flexion gap was wider in the aMA group, with a mean of 0.71 mm more laxity (p = 0.001). Postoperative coronal alignment was 177.03° ± 1.82° in aMA group versus 178.14° ± 1.69° in MA group (p < 0.001). …”
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    Mid‐Term Outcomes of Navigation‐Assisted Primary Total Knee Arthroplasty Using Adjusted Mechanical Alignment
  15. 147635
    “…Controlled hypertension, defined as a mean systolic and diastolic blood pressure below 140 and 90 mmHg, respectively, was the primary endpoint assessed. …”
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    Effectiveness of a provider and patient-focused intervention to improve hypertension management and control in the primary health care setting in Cuba: a controlled before-after study
  16. 147636
    “…The rate of Grade A was considered the perfect accuracy rate, and the rate of penetration of 2 mm or more (Grades C, D, and E) was calculated as the deviation rate. …”
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    Accuracy and Screw Insertion Time of Robotic-Assisted Cortical Bone Trajectory Screw Placement for Posterior Lumbar Interbody Fusion: A Comparison of Early, Middle, and Late Phases
  17. 147637
    “…MS medium augmented with indole-3-acetic acid (1.0 mg·L(−1)) produced the highest root number (9 ± 0.89) and maximum root length (20.88 ± 1.48 mm) from regenerated C. pilosula shoots. The survival rate of in vitro-regenerated C. pilosula plants was 94.00% after acclimatization. …”
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    In vitro propagation of Codonopsis pilosula (Franch.) Nannf. using apical shoot segments and phytochemical assessments of the maternal and regenerated plants
  18. 147638
    “…The risk factors of TVR in the patients with successful re-attempt CTO-PCI were stent length > 100 mm (adjusted HR 21.805, 95% CI 1.765–269.368, P = 0.016) and J-CTO score > 3(adjusted HR: 9.733, 95% CI:1.533–61.797, P = 0.016). …”
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    Long term clinical outcome after success re-attempt percutaneous coronary intervention of chronic total occlusion
  19. 147639
    “…The secondary outcome is the incidence of severe complications between induction and 2 min after intubation, defined as the occurrence of one or more of the following: severe hypoxaemia (lowest oxygen saturation <80%); severe hypotension (systolic blood pressure <65 mm Hg or new or increased vasopressor administration); cardiac arrest or death. …”
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    DirEct versus VIdeo LaryngosCopE (DEVICE): protocol and statistical analysis plan for a randomised clinical trial in critically ill adults undergoing emergency tracheal intubation
  20. 147640
    “…PASP was lower in ICU survivors (32.5 ± 9.8 vs. 40.4 ± 14.3 mmHg, p = 0.024). B-pattern was more often detected in non-survivors (35/59 (59%) vs. 19/58 (33%), p = 0.005). …”
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    Pulmonary hypertension at admission predicts ICU mortality in elderly critically ill with severe COVID-19 pneumonia: retrospective cohort study
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