“…Acute phase markers were elevated with ESR 99 mm/hr, CRP 79 mg/l and ferritin 1194 ng/ml. Ultrasound (US) hands confirmed widespread active synovitis involving bilateral wrist and metacarpophalangeal joints. …”
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“…Linfopenia, definida como valores menores que 1000/mm³, foi um fator associado à baixa soro conversão (37,5 vs 75%, p = 0,087). …”
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“…MATERIAL E MÉTODOS: Pacientes admitidos no Hospital de Clínicas de Porto Alegre (HCPA) entre junho/2020 e maio/2021 foram divididos em dois grupos quanto à severidade da COVID-19; grupo severo (GS): saturação de SpO(2) < 93% em ar ambiente e/ou aumento da frequência respiratória > 30 batimentos/min e/ou relação PaO(2)/FiO(2) ≤ 300 mmHg e grupo não severo (GNS): pacientes que não se enquadraram nesses critérios. …”
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“…La biologie a montré un syndrome inflammatoire biologique persistant (VS supérieur à 100 mm/h1, CRP à 180 mg/L). La procalcitonine était négative. …”
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“…Eleven had chronic lymphocytic leukemia (CLL), 7 non-Hodgkin's lymphoma (NHL), 5 Waldenstrom's macroglobulinemia (WM), and 1 multiple myeloma (MM). Six patients were not currently on anti-B cell therapy, 11 had received anti-CD20 therapy (8 within the last 6 months), 6 had received Bruton's tyrosine kinase (BTK) inhibitors within the last 6 months, and 1 patient had recently received chemotherapy. …”
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“…Inclusion criteria were diaphyseal unstable fractures defined as shaft fractures between the distal and proximal metaphyses with an angulation of > 10°, and/or malrotation of > 30°, and/or displacement > 10 mm after attempted closed reduction. Exclusion criteria included open fractures, Galeazzi fractures, Monteggia fractures, radial head fractures, and associated neurovascular injuries. …”
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“…For lesions characteristics, prior CABG patients had more blunt stump (OR, 1.71; 95% CI, 1.46–2.00; p < .001; I (2) = 40%), proximal cap ambiguity (OR, 1.45; 95% CI, 1.28–1.64; p < .001; I (2) = 0.0%), severe calcifications (OR, 2.91; 95% CI, 2.19–3.86; p < .001; I (2) = 83%), more bending (OR, 3.07; 95% CI, 2.61–3.62; p < .001; I (2) = 0%), lesion length > 20 mm (OR, 1.59; 95% CI, 1.10–2.29; p = .01; I (2) = 83%), inadequate distal landing zone (OR, 1.95; 95% CI, 1.75–2.18; p＜.001; I (2) = 0.0%), distal cap at bifurcation (OR, 1.65; 95% CI, 1.46–1.88; p < .001; I (2) = 0.0%), and higher J‐CTO score (SMD, 0.52; 95% CI, 0.42–0.63; p < .001; I (2) = 65%). …”
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“…Blood tests showed raised C-Reactive Protein (38 mg/L), and Erythrocyte Sedimentation Rate (62 mm/hr), with normochromic normocytic anaemia but other blood counts were normal. …”
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“…At the completion of the hormonal stimulation, ovarian ultrasound scans were performed to evaluate the dominant follicle (DF) and cows with DF > 8.5 mm in diameter emerging on their ovaries were defined as having experienced a response to hormonal stimuli. …”
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“…Les caractéristiques de ces PDV sont : 49 (73 %) hommes, âge médian 45.7 ans [25-80], 36 (54 %) étrangers dont 22 (33 %) originaires d'Afrique Subsaharienne, avec un mode de transmission hétérosexuelle chez 32 (48 %), homosexuelle chez 27 (40 %), par usage de drogue intraveineuse chez 3 (4 %), inconnue chez 5 (7 %), une médiane d'ancienneté VIH de 10.7 ans [1-33], une médiane de CD4 à 474/mm3 [23-1293], 17 (25 %) avaient une CV VIH > 50 cp/ml, un stade CDC A chez 55 (82 %) et C chez 12 (18 %). …”
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“…L’examen objectivait une fièvre à 39 °C, un état hémodynamique stable, une pression artérielle à 11/06 mmHg et une tachycardie à 110 bpm. La saturation pulsée de l’oxygène était à 95 % à l’air ambiant. …”
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“…À l’admission en réanimation, le score SOFA médian était de 4 [4–6,3] et le rapport PaO2/FiO2 médian de 84 [69–128]mmHg. Une oxygénothérapie humidifiée à haut débit a été initiée chez 79 (79 %) patients et une ventilation non invasive chez 18 (18 %) patients. …”
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“…After the WM intervention, older adults lost more fat-free mass and bone mass and had smaller improvements in 2 h plasma glucose (adjusted difference for older vs younger adults 0.65 mmol/l [95% CI 0.50, 0.80], p<0.001) and systolic blood pressure (adjusted difference for older vs younger adults 2.57 mmHg [95% CI 1.37, 3.77], p<0.001) than younger adults. …”
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“…Average graft size was 9.5mm for the quad autograft group and 10 for the BTB autograft group. …”
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“…A fused-silica capillary column (Rtx-CL Pesticides2, 30 m×0.25 mm×0.2 μm) was used to separate the target compounds. …”
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“…Abbreviations: ADA Anti-drug antibody; ADCC Antibody-dependent cellular cytotoxicity; ADCP Antibody-dependent cellular phagocytosis; ADC Antibody-drug conjugate; aFc Aglycosylated Fc; AMD Age-related macular degeneration aTTP Acquired thrombotic thrombocytopenic purpura; BCMA B-cell maturation antigen; BLA Biologics license application; BsAb Bispecific antibody; C1q Complement protein C1q; CDC Complement-dependent cytotoxicity; CDCC Complement-dependent cellular cytotoxicity; CDCP Complement-dependent cellular phagocytosis; CEX Cation exchange chromatography; CFPS Cell-free protein expression; CHO Chinese Hamster Ovary; CH1-3 Constant heavy chain 1-3; CL Constant light chain; DLBCL Diffuse large B-cell lymphoma; DAR Drug antibody ratio; DC Dendritic cell; dsFv Disulfide-stabilized Fv; EU European Union; EGFR Epidermal growth factor receptor; E. coli Escherichia coli; EpCAM Epithelial cell adhesion molecule; Fab Fragment antigen binding; FACS Fluorescence activated cell sorting; Fc Fragment crystallizable; FcRn Neonatal Fc receptor; FcɣRs Fc gamma receptors; FDA Food and Drug Administration; FL-IgG Full-length immunoglobulin; Fv Fragment variable; FolRαa Folate receptor alpha; gFc Glycosylated Fc; GM-CSF Granulocyte macrophage-colony stimulating factor; GPx7 Human peroxidase 7; HCL Hairy cell leukemia; HIV Human immunodeficiency virusl; HER2 Human epidermal growth factor receptor 2; HGF Hepatocyte growth factor; HIC Hydrophobic interaction chromatography; HLA Human leukocyte antigen; IBs Inclusion bodies; IgG1-4 Immunoglobulin 1-4; IP Intraperitoneal; ITC Isothermal titration calorimetry; ITP Immune thrombocytopenia; IV Intravenous; kDa Kilodalton; KiH Knob-into-Hole; mAb Monoclonal antibody; MAC Membrane-attack complex; mCRC Metastatic colorectal cancer; MM Multipl myeloma; MOA Mechanism of action; MS Mass spectrometry; MUC1 Mucin 1; MG Myasthenia gravis; NB Nanobody; NK Natural killer; nsAA Nonstandard amino acid; NSCLC Non-small cell lung cancer; P. aeruginosa Pseudomonas aeruginosa; PD-1 Programmed cell death 1; PD-L1 Programmed cell death-ligand 1; PDI Protein disulfide isomerase; PECS Periplasmic expression cytometric screening; PK Pharmacokinetics; P. pastoris Pichia pastoris; PTM Post-translational modification; Rg Radius of gyration; RA Rheumatoid arthritis; RT-PCR Reverse transcription polymerase chain reaction; SAXS Small angle X-ray scattering; scF Single chain Fv; SCLC Small cell lung cancer; SDS-PAGE Sodium dodecyl sulfate–polyacrylamide gel electrophoresis; SEC Size exclusion chromatography; SEED Strand-exchange engineered domain; sRNA Small regulatory RNA; SRP Signal recognition particle; T1/2 Half-life; Tagg Aggregation temperature; TCR T cell receptor; TDB T cell-dependent bispecific; TF Tissue factor; TIR Translation initiation region; Tm Melting temperature; TNBC Triple-negative breast cancer; TNF Tumor necrosis factor; TPO Thrombopoietin; VEGF Vascular endothelial growth factor; vH Variable heavy chain; vL Variable light chain; vWF von Willebrand factor; WT Wild type…”
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“…Initial blood tests showed: haemoglobin 156 g/L, white cell count 13 x 10(9)/L (neutrophilia: 10.6 x 10(9)/L), platelets 514 x 10(9)/L, CRP 123 mg/L, ESR 12 mm/hr, normal renal and liver function. Detailed immunology, microbiology and viral screens were negative including anti-neutrophil cytoplasmic antibodies (ANCA) and cryoglobulins. …”
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“…Investigations showed CRP <5, ESR 80mm/hour, WCC 15.45 (x10*9/L), ALT 43 (U/L), AST 80 (U/L), CK 21 (U/L), LDH 639 (U/L). …”
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“…Therefore, additional management in sows with high backfat thickness (>24 mm) before farrowing should be considered to avoid the crushing of piglets by sows.…”
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“…Each wedge corresponds to either a sTGC layer or MicroMega (MM) detector, and each wedge has four layers. This makes for a total of 8 sTGC layers and 8 MM layers for each sector. …”
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