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  1. 46001
    “…Due to intensive interspecific hybridizations, modern cut roses are complex tetraploids for which the mode of inheritance is not exactly known. …”
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    The mode of inheritance in tetraploid cut roses
  2. 46002
    por Spreadbury, Ian
    Publicado 2012
    “…A diet of grain-free whole foods with carbohydrate from cellular tubers, leaves, and fruits may produce a gastrointestinal microbiota consistent with our evolutionary condition, potentially explaining the exceptional macronutrient-independent metabolic health of non-Westernized populations, and the apparent efficacy of the modern “Paleolithic” diet on satiety and metabolism.…”
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    Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity
  3. 46003
    “…We demonstrate their utility—using modern simulation protocols, optimized force fields, and inclusion of explicit solvent and mobile counterions—by re-investigating the solution structures of two RNA hairpins that had previously been refined using conventional techniques. …”
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    Molecular dynamics re-refinement of two different small RNA loop structures using the original NMR data suggest a common structure
  4. 46004
    “…There is a crucial need for making these previously generated models suitable for modern methods of tumour visualisation and monitoring, e.g. by bioluminescence-based techniques. …”
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    Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice
  5. 46005
    “…Surprisingly, in our modern 24/7 society, there is scant information on the impact of developmental chronodisruption like the one experienced by shift worker pregnant women on fetal and postnatal physiology. …”
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    Timed Maternal Melatonin Treatment Reverses Circadian Disruption of the Fetal Adrenal Clock Imposed by Exposure to Constant Light
  6. 46006
    “…Species delimitation and species concepts have been a matter of debate among biodiversity researchers in the last decades, resulting in integrative taxonomy approaches and the use of modern species concepts, such as the phylogenetic, evolutionary or general lineage species concepts. …”
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    Island Evolution and Systematic Revision of Comoran Snakes: Why and When Subspecies Still Make Sense
  7. 46007
    por Wang, Gordon, Smith, Stephen J.
    Publicado 2012
    “…The physical sectioning of AT allows tissue specimens to be imaged at the physical optimum of modern high NA plan-apochormatic objectives. This translates to images that have little out of focus light, minimal aberrations and wave-front distortions. …”
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    Sub-diffraction Limit Localization of Proteins in Volumetric Space Using Bayesian Restoration of Fluorescence Images from Ultrathin Specimens
  8. 46008
    “…SUMMARY: The ICF framework reflects modern thinking in disability evaluation. It allows for the medical expert to describe work disability as a bio-psycho-social concept, and what components are of importance in disability evaluation for the medical expert. …”
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    Evaluation of work disability and the international classification of functioning, disability and health: what to expect and what not
  9. 46009
    “…However, persistence is highly relevant in changing modern landscapes, especially for invasive species that dynamically spread in unstable human-made habitats. …”
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    Low persistence of a monocarpic invasive plant in historical sites biases our perception of its actual distribution
  10. 46010
    “…BACKGROUND AND AIMS: Although smoke inhalation is well known to cause acute lung injury, there are few reports in literature that study the evolution, clinical course and outcomes of isolated inhalational lung injury in a modern intensive care setting. A major fire disaster provided us the opportunity to study victims of isolated inhalational injury admitted to our Multidisciplinary Intensive Care Unit (MICU). …”
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    Isolated inhalational injury: Clinical course and outcomes in a multidisciplinary intensive care unit
  11. 46011
    “…CONCLUSIONS: HEK 293 F cells, whose parental cell line HEK 293 has been used by researchers for decades, are a suitable production cell line for rhFVIII and will help avoid immunogenic epitopes. A modern manufacturing process has been developed to ensure the highest level of purity and pathogen safety.…”
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    The first recombinant human coagulation factor VIII of human origin: human cell line and manufacturing characteristics
  12. 46012
    “…The genetics of KIR2DL5 is complicated by duplication of its gene in an ancestor of modern humans living ∼1.7 million years ago. Both KIR2DL5 paralogs have undergone allelic diversification; the centromeric gene is most often represented by alleles whose expression is silenced epigenetically through DNA methylation, thus providing a natural system to investigate the regulation of KIR transcription. …”
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    KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression
  13. 46013
    “…One of the most pressing problems facing modern medical researchers is the surging levels of obesity, with the consequent increase in associated disorders such as diabetes and cardiovascular disease (1-3). …”
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    Endurance Training Protocol and Longitudinal Performance Assays for Drosophila melanogaster
  14. 46014
    “…Elucidation of the molecular mechanisms of activation of G protein-coupled receptors (GPCRs) is among the most challenging tasks for modern membrane biology. For studies by high resolution analytical methods, these integral membrane receptors have to be expressed in large quantities, solubilized from cell membranes and purified in detergent micelles, which may result in a severe destabilization and a loss of function. …”
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    Stabilization of Functional Recombinant Cannabinoid Receptor CB(2) in Detergent Micelles and Lipid Bilayers
  15. 46015
    “…The initial split of caviids is followed by an obscure period of poor fossil record (refered here as the Mayoan gap) and then by the appearance of highly differentiated modern lineages of caviids, which evidentially occurred at the late Miocene as indicated by both the fossil record and molecular clock estimates. …”
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    Major Radiations in the Evolution of Caviid Rodents: Reconciling Fossils, Ghost Lineages, and Relaxed Molecular Clocks
  16. 46016
    por Spratt, Daniel E, Lee, Nancy
    Publicado 2012
    “…Multiple randomized Phase III trials have shown the benefit of chemo-RT; however, none of these studies utilized modern radiotherapy (RT) techniques of intensity-modulated radiation therapy (IMRT). …”
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    Current and emerging treatment options for nasopharyngeal carcinoma
  17. 46017
    “…These findings underline the need to change our focus from the formal context (classroom) to the informal context to optimize student learning and deliver modern medics.…”
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    Visualising the invisible: a network approach to reveal the informal social side of student learning
  18. 46018
    “…These peaks may be explainable by human experts but the scale of modern proteomics experiments makes this impractical. …”
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    Expert System for Computer-assisted Annotation of MS/MS Spectra
  19. 46019
    “…This means that for the first time, the action mechanism of these three important Chinese herbs for the treatment of CVD is uncovered, by generating and identifying both their active ingredients and novel targets specifically related to CVD, which clarifies some of the common conceptions in TCM, and thus provides clues to modernize such specific herbal medicines.…”
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    A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease
  20. 46020
    “…Our findings provide an historical explanation for the sensitivity of modern SRs to natural and synthetic ligands—including endocrine-disrupting drugs and pollutants—and show that knowledge of history can contribute to ligand prediction. …”
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    Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors
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