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  1. 47501
    “…INTRODUCTION: Lobular carcinoma in situ (LCIS) has been accepted as a marker of risk for the development of invasive breast cancer, yet modern models of breast carcinogenesis include LCIS as a precursor of low-grade carcinomas. …”
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    Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions
  2. 47502
    “…In this narrative review, we aim to summarise the findings of the FP7 GP-TCM project and highlight the relevance of TCM to modern medicine within a historical and international context. …”
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    The quest for modernisation of traditional Chinese medicine
  3. 47503
    “…RESULTS: Meeting family planning needs by 2020 would increase prevalence of modern contraception in 2025 from 36.8 to 65.5% in Vanuatu and 28.5 to 37.6% in the Solomon Islands. …”
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    The case for investing in family planning in the Pacific: costs and benefits of reducing unmet need for contraception in Vanuatu and the Solomon Islands
  4. 47504
    “…In addition, we identified the ancestral mitochondrial D-loop signature present in these 2713 sequences and found that ~ 80% carried the European ancient signatures, ANC-Aside and ANC-Cside or their closely related signatures, while most of the remaining sequences carried a modern Asian signature, ANC-Easia. Mangalica individuals carried the ANC-Aside signature, but not the ANC-Cside or ANC-Easia signatures. …”
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    Introgression and isolation contributed to the development of Hungarian Mangalica pigs from a particular European ancient bloodline
  5. 47505
    “…OBJECTIVES: A well-known demographic finding in modern society is the inverse association between socioeconomic status and mortality. …”
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    Mortality risks in relation to occupational category and position among the Japanese working population: the Jichi Medical School (JMS) cohort study
  6. 47506
    por Seo, Jeong Kee
    Publicado 2012
    “…Because advancement of modern biochemical technology now allows more rapid, easier, and less expensive mutation detection, direct DNA sequencing could be actively considered as the primary mode of diagnostic investigation rather than a supplementary test to the conventional biochemical tests. …”
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    Diagnosis of Wilson Disease in Young Children: Molecular Genetic Testing and a Paradigm Shift from the Laboratory Diagnosis
  7. 47507
    “…Surgical treatment is reserved for specific conditions. Modern concepts of internal fixation of long bone shaft fractures advocate relative stabilisation techniques with no harm to fracture zone. …”
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    Treatment of the humeral shaft fractures - minimally invasive osteosynthesis with bridge plate versus conservative treatment with functional brace: study protocol for a randomised controlled trial
  8. 47508
    “…High fat diet (HFD) is prevalent in many modern societies and HFD-induced metabolic condition is a growing concern worldwide. …”
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    Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice
  9. 47509
    “…This implied that some haplotypes predate modern breed formation and remain in strong linkage disequilibrium. …”
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    Imputation of microsatellite alleles from dense SNP genotypes for parentage verification across multiple Bos taurus and Bos indicus breeds
  10. 47510
    “…Alzheimer's disease (AD) is a devastating disorder of increasing prevalence in modern society. Mild cognitive impairment (MCI) is considered a transitional stage between normal aging and AD; however, not all subjects with MCI progress to AD. …”
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    Integrative EEG biomarkers predict progression to Alzheimer's disease at the MCI stage
  11. 47511
    “…RNA silencing was likely present in the common ancestor of modern eukaryotes, but most research has focused on plant and animal RNA silencing systems. …”
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    Phytophthora Have Distinct Endogenous Small RNA Populations That Include Short Interfering and microRNAs
  12. 47512
    “…Conclusion: We have identified several risk factors for any wheeze in young infants living in modern day Cuba. As the prevalence of smoking in the house is high (51%), intervention studies are required to determine effective strategies to improve infant health.…”
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    Risk factors for wheezing in infants born in Cuba
  13. 47513
    “…CONCLUSIONS: In our study, few individuals normalized their CD4:CD8 ratios within the first few years of initiating modern cART. This large study showed no additional short-term predictive value of the CD4:CD8 ratio for clinical outcomes after accounting for other risk factors including age and HIV RNA.…”
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    Predictors of CD4:CD8 Ratio Normalization and Its Effect on Health Outcomes in the Era of Combination Antiretroviral Therapy
  14. 47514
    “…Bystander responses have attracted attention in modern radiobiology because they are characterized by non-linear responses to low-dose radiation. …”
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    X-ray-induced bystander responses reduce spontaneous mutations in V79 cells
  15. 47515
    “…BACKGROUND: In the late '80s the successes of the laparoscopic surgery for gallbladder disease laid the foundations on the modern use of this surgical technique in a variety of diseases. …”
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    Laparoscopic vs. open approach for colorectal cancer: evolution over time of minimal invasive surgery
  16. 47516
    “…In the midst of the tremendous efforts that have brought PARP inhibitors to the forefront of modern chemotherapy, most clinically used PARP inhibitors bind to conserved regions that permits cross-selectivity with other PARPs containing homologous catalytic domains. …”
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    Structural Implications for Selective Targeting of PARPs
  17. 47517
    “…Modern anti-retroviral therapy is highly effective at suppressing viral replication and restoring immune function in HIV-infected persons. …”
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    In Vivo Mitochondrial Function in HIV-Infected Persons Treated with Contemporary Anti-Retroviral Therapy: A Magnetic Resonance Spectroscopy Study
  18. 47518
    “…BACKGROUND: Modern-day health systems are complex, making it difficult to assure continuity of care for older persons with multi-morbidity. …”
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    Case managers for older persons with multi-morbidity and their everyday work – a focused ethnography
  19. 47519
    “…Frequent and devastating epidemics of parasites are one of the major issues encountered by modern agriculture. To manage the impact of pathogens, resistant plant varieties have been selected. …”
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    The variety mixture strategy assessed in a G × G experiment with rice and the blast fungus Magnaporthe oryzae
  20. 47520
    “…RESEARCH DESIGN AND METHOD: Modern metabolic profiling technology (MxP™ Broad Profiling) was applied to find early alterations in the plasma metabolome of type-2 diabetic patients. …”
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    A New Metabolomic Signature in Type-2 Diabetes Mellitus and Its Pathophysiology
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