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  1. 47981
    “…Herein, we aim to evaluate the association between TTC and prognosis among different subtypes in modern era of adjuvant chemotherapy. BC patients receiving operation and adjuvant chemotherapy between January 2009 and December 2015 were included. …”
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    Prolonged Time to Adjuvant Chemotherapy Initiation Was Associated with Worse Disease Outcome in Triple Negative Breast Cancer Patients
  2. 47982
    por Liu, Siyu, Bi, Yingjie, Liu, Yawen
    Publicado 2020
    “…Directly observed treatment and short course chemotherapy (DOTS) strategy combines medicine care and modern health system firmly, and it has been carried out by World Health Organization (WHO) since 1997. …”
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    Modeling and dynamic analysis of tuberculosis in mainland China from 1998 to 2017: the effect of DOTS strategy and further control
  3. 47983
    “…In this context, different populations of both teosinte subspecies have contributed to modern maize's gene pool. Our results point towards a long period of domestication marked by gene flow with wild relatives, confirming domestication as long and ongoing process.…”
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    The relevance of gene flow with wild relatives in understanding the domestication process
  4. 47984
    “…INTRODUCTION: The aging of modern societies increases the general healthcare burden due to the growing demand for inpatient services, which lack adequate financing. …”
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    An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends
  5. 47985
    “…Qualitative and quantitative research examining modern radiotherapy learning has been uncommon and uncoordinated, until recently. …”
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    Learning radiotherapy: the state of the art
  6. 47986
    “…[Image: see text] Excitons play major roles in optical processes in modern semiconductors, such as single-wall carbon nanotubes (CNTs), transition metal dichalcogenides, and 2D perovskite quantum wells. …”
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    Terahertz Excitonics in Carbon Nanotubes: Exciton Autoionization and Multiplication
  7. 47987
    “…DISCUSSION: The present study has been established on the basis of the “meridian–viscera relationship” theory of traditional Chinese medicine and the modern central mechanism of acupuncture. The results of this trial would be useful to identify the efficiency of the specific meridian acupuncture for asthma. …”
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    Effect of acupuncture and its influence on cerebral activity in patients with persistent asthma: study protocol for a randomized controlled clinical trial
  8. 47988
    “…To overcome these issues, we analyzed 38 high-coverage whole-genome sequences representative of population clusters at the opposite ends of the cline of Italian variation, along with a large panel of modern and ancient Euro-Mediterranean genomes. RESULTS: We provided evidence for the early divergence of Italian groups dating back to the Late Glacial and for Neolithic and distinct Bronze Age migrations having further differentiated their gene pools. …”
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    Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans
  9. 47989
    “…We took advantage of the largest GWAS meta-analysis available for this disorder consisting of over 20,000 individuals diagnosed with ADHD and 35,000 controls, to assess the evolution of ADHD-associated alleles in European populations using archaic, ancient and modern human samples. We also included Approximate Bayesian computation coupled with deep learning analyses and singleton density scores to detect human adaptation. …”
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    Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples
  10. 47990
    “…RESULTS: In cars compliant with the new regulations, gasoline (E10) displayed the highest PM concentrations and toxicological responses, while the higher ethanol blend (E85) resulted in slightly lower exhaust gas PM concentrations and notably lower toxicological responses in comparison. Engines powered by modern diesel and compressed natural gas (CNG) yielded the lowest PM concentrations and toxicological responses. …”
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    Toxicological evaluation of exhaust emissions from light-duty vehicles using different fuel alternatives in sub-freezing conditions
  11. 47991
    “…Extremely low nucleotide diversity of modern horse Y-chromosome has been reported, and only poor phylogenetic resolution could be resulted from limited Y-chromosome markers. …”
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    Ancient Patrilineal Lines and Relatively High ECAY Diversity Preserved in Indigenous Horses Revealed With Novel Y-Chromosome Markers
  12. 47992
    “…The integration of MRI and PT at the treatment isocenter would offer the opportunity of combining the unparalleled soft-tissue contrast and real-time imaging capabilities of MRI with the most conformal dose distribution and best dose steering capability provided by modern PT. However, hybrid systems for MR-integrated PT (MRiPT) have not been realized so far due to a number of hitherto open technological challenges. …”
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    MR-guided proton therapy: a review and a preview
  13. 47993
    “…Phylogenetic analysis of prenyltransferases suggests that PGTs originated in a common ancestor of modern shikonin/alkannin-producing Boraginaceous species, likely from a retrotransposition-derived duplication event of an ancestral prenyltransferase gene. …”
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    Hybrid de novo genome assembly of red gromwell (Lithospermum erythrorhizon) reveals evolutionary insight into shikonin biosynthesis
  14. 47994
    “…The literacy component of writing is less researched than that of reading, even though it holds equal significance for modern success. Spelling is an important aspect of the construct of literacy, and is more difficult to acquire than reading. …”
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    The Impact of Different Writing Systems on Children’s Spelling Error Profiles: Alphabetic, Akshara, and Hanzi Cases
  15. 47995
    “…Despite improved outcomes in the modern era of targeted immunotherapy, intestinal failure and chronic parenteral nutrition remains a significant burden for patients with Crohn’s disease (CD) worldwide. …”
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    Immunologic Complications and Graft Survival in Crohn’s Disease and NOD2 Mutant Non-Crohn’s Disease Adult Recipients Following Intestine Transplantation
  16. 47996
    “…PURPOSE: The COVID‐19 pandemic has led to disorder in work and livelihood of a majority of the modern world. In this work, we review its major impacts on procedures and workflow of clinical physics tasks, and suggest alternate pathways to avoid major disruption or discontinuity of physics tasks in the context of small, medium, and large radiation oncology clinics. …”
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    Mitigating disruptions, and scalability of radiation oncology physics work during the COVID‐19 pandemic
  17. 47997
    “…METHODS: We evaluated 182 MBM patients, who were treated with GKRS in the modern radiosurgical and oncological era. RESULTS: The median time between the initial melanoma diagnosis and occurrence of MBM was 2.4 years. …”
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    Toxicity and efficacy of Gamma Knife radiosurgery for brain metastases in melanoma patients treated with immunotherapy or targeted therapy—A retrospective cohort study
  18. 47998
    “…Plant height (PH) was a target of artificial selection during rice domestication and is still a target of modern breeding. The “green revolution” gene semi-dwarf 1 (SD1) were well documented and used in the past decades, allele from wild rice could provide new insights into the functions and evolution of this gene. …”
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    Identification and genetic analysis of qCL1.2, a novel allele of the “green revolution” gene SD1 from wild rice (Oryza rufipogon) that enhances plant height
  19. 47999
    “…Studying microbial fossils is fundamental for our understanding of the role microorganisms have played in elemental cycling in modern and ancient environments on Earth and potentially Mars. …”
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    Characterisation of iron oxide encrusted microbial fossils
  20. 48000
    “…Modern intensively managed pastures that receive large external nitrogen (N) inputs account for high N losses in form of nitrate (NO(3)(–)) leaching and emissions of the potent greenhouse gas nitrous oxide (N(2)O). …”
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    Biological Nitrification Inhibition (BNI): Phenotyping of a Core Germplasm Collection of the Tropical Forage Grass Megathyrsus maximus Under Greenhouse Conditions
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