“…The mechanisms of allogenous selection are (a) collateral expansion, when the antibiotic expands the gene and gene-containing bacterial populations favoring the emergence of other mutations, inactivating the more advanced antibiotics; (b) collateral selection, when the old antibiotic selects its own resistance but also resistance to more modern drugs; (c) collateral hyper-resistance, when resistance to the old antibiotic selects in higher degree for populations resistant to other antibiotics of the family than to itself; and (d) collateral evolution, when the simultaneous or sequential use of antibiotics of the same family selects for new mutational combinations with novel phenotypes in this family, generally with higher activity (higher inactivation of the antibiotic substrates) or broader spectrum (more antibiotics of the family are inactivated). …”
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“…The pandemic also appears to have offered many girls a respite from the chronic stress of modern teen life, with time to relax and engage in creative and healthy pursuits showing benefits for daily emotional health, which should be considered following the return to normal life.…”
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“…MOTIVATION: Assessment of genetic mutations is an essential element in the modern era of personalized cancer treatment. Our strategy is focused on ‘multiple network analysis’ in which we try to improve cancer diagnostics by using biological networks. …”
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“…In this study, precision feeding techniques are highlighted given their applicability to modern pig and poultry farming. These novel feeding strategies are good examples of innovative strategies needed to break paradigms, improve resource-use efficiency, and effectively move the current productive scenario toward more sustainable livestock systems.…”
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“…Scaffold hopping is a central task of modern medicinal chemistry for rational drug design, which aims to design molecules of novel scaffolds sharing similar target biological activities toward known hit molecules. …”
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“…We reviewed the impact of polio SIAs on routine immunisation and health systems during the modern era of polio eradication. METHODS: We searched nine databases for studies reporting on polio SIAs and immunisation coverage, financial investment, workforce and health services delivery. …”
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“…Recommendations included clarification of ICH-GCP’s scope, proportionality in various aspects of clinical trials, diversity and liquidity of ethics committee members, modernization of informed consent procedures, variations in monitoring, and regulatory grade when using real-world data. …”
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“…BACKGROUND: Chemical fertilization helped modern agriculture in grain yield improvement to ensure food security. …”
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“…CONCLUSION: Intervention to improve knowledge of tobacco harmful effects, and access to multiple and modern antismoking communication channels would be effective to raise quit attempt among smokers. …”
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“…In countries where the role is under development, regulators can leverage these findings to establish modernized nurse practitioner scope of practice policies from the outset.…”
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“…INTRODUCTION: Difficult healing of chronic wounds is a serious problem for modern medicine. It leads to ulceration, especially in conditions such as diabetic foot syndrome or chronic venous insufficiency. …”
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“…Due to modernization and the scarcity of fossil fuel resources, energy demand is continuously increasing. …”
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“…The COVID-19 pandemic significantly destructs the rhythm of global modern human civilization but worldwide lockdown radically recovers the health of the total environment. …”
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“…Herein, the representative hemicelluloses and lignin with unaltered structures were prepared from control (CK) and C3H down-regulated 84K poplars. Modern analytical techniques, such as (13)C NMR, 2D-HSQC NMR, and gel chromatography (GPC), were performed to better delineate the structural changes of hemicelluloses and lignin caused by transgenesis. …”
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“…Attending secondary school or above (AOR = 2.42, 95% CI: 1.24-4.74), using modern contraceptives (AOR = 6.31, 95% CI: 2.86-13.89), knowing somebody with cervical cancer (AOR = 2.24, 95% CI: 1.35-3.71) and knowing someone screened for cervical cancer (AOR = 2.23, 95% CI: 1.30-3.80) were associated with knowledge of cervical cancer. …”
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“…VARDNN learns to reproduce experimental time series data using modern deep learning training techniques. Based on this, we developed two novel directed functional connectivity (dFC) measures, namely VARDNN-DI and VARDNN-GC. …”
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“…Qualitative analysis highlighted that the patient's thoughts on cancer are dominated by negative associations, although curability and modern therapy are also frequently cited. CONCLUSION: We adapted an educational booklet to a novel context and had it delivered by local partners. …”
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“…Zirconium dioxide (ZrO(2)) is one of the ceramic materials with high potential in many areas of modern technologies. ZrO(2) doped with 8 wt.% (~4.5 mol%) Y(2)O(3) is a commercial powder used for obtaining stabilized zirconia materials (8 wt.% YSZ) with high temperature resistance and good ionic conductivity. …”
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“…These resources include cell lines, animal models, mesothelioma-specific biobanks and modern laboratory techniques/technologies. Given that different preclinical models and laboratory technologies have varying limitations and applications, they must be selected carefully with respect to the intended objectives of the experiments. …”
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“…Despite their availability and accessibility, modern family planning methods are reported to be critically underutilized by adolescents. …”
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