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  1. 51101
    “…Despite the clinically proven efficacy of whole abdominal irradiation, the use of radiotherapy in ovarian cancer has profoundly decreased mainly due to high treatment-related toxicity. Modern intensity-modulated radiation therapy (IMRT) could allow to spare kidneys, liver, and bone marrow while still adequately covering the peritoneal cavity with a homogenous dose. …”
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    Adjuvant whole abdominal intensity modulated radiotherapy (IMRT) for high risk stage FIGO III patients with ovarian cancer (OVAR-IMRT-01) – Pilot trial of a phase I/II study: study protocol
  2. 51102
    por Fosså, S D, Aass, N, Harvei, S, Tretli, S
    Publicado 2004
    “…Patients with MGCT have a significantly increased relative death risk due to a second nongerm cell cancer, even after the introduction of modern treatment principles with overall reduction of radiotherapy. …”
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    Increased mortality rates in young and middle-aged patients with malignant germ cell tumours
  3. 51103
    “…The discovery of nucleases with unique properties has often served as the basis for the development of modern molecular biology methods. Thus, the search for novel nucleases with potentially exploitable functions remains an important scientific undertaking. …”
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    Isolation, characterization and molecular cloning of Duplex-Specific Nuclease from the hepatopancreas of the Kamchatka crab
  4. 51104
    “…These data allow an appreciation of the range of clinical phenotype, modern imaging and molecular investigation and should inform genetic counselling of at-risk individuals, with the identification of two genetic modifiers.…”
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    Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series
  5. 51105
    “…BACKGROUND: Previous studies suggested that multiple domestication events in South and South-East Asia (Yunnan and surrounding areas) and India have led to the genesis of modern domestic chickens. Ha Giang province is a northern Vietnamese region, where local chickens, such as the H'mong breed, and wild junglefowl coexist. …”
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    Genetic analysis of local Vietnamese chickens provides evidence of gene flow from wild to domestic populations
  6. 51106
    “…With its modular workflow design and numerous graphical user interfaces, Gene Composer enables researchers to perform all common bio-informatics steps used in modern structure guided protein engineering and synthetic gene engineering. …”
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    Gene Composer: database software for protein construct design, codon engineering, and gene synthesis
  7. 51107
    “…Identification of anti-schistosomal chemicals has traditionally relied on phenotypic (whole organism) screening with adult worms in vitro and/or animal models of disease—tools that limit automation and throughput with modern microtiter plate-formatted compound libraries. …”
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    Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening
  8. 51108
    “….: 17–43 kya), long after archeological evidence places modern humans in Europe. Finally, we estimate divergence between East Asians (CHB) and Mexican-Americans (MXL) of 22 kya (95% c.i.: 16.3–26.9 kya), and our analysis yields no evidence for subsequent migration. …”
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    Inferring the Joint Demographic History of Multiple Populations from Multidimensional SNP Frequency Data
  9. 51109
    “…In the following we will consider this circumstance from philosophical, scientific, and epistemological perspectives, surmising that phylogeny opted for a single model as a holdover from the Modern Synthesis of evolution. RESULTS: It was far easier to envision and defend the concept of a universal tree of life before we had data from genomes. …”
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    Prokaryotic evolution and the tree of life are two different things
  10. 51110
    “…An accurate and saturated genetic linkage map of soybean is an essential tool for studies on modern soybean genomics. In order to update the linkage map of a F(2) population derived from a cross between Misuzudaizu and Moshidou Gong 503 and to make it more informative and useful to the soybean genome research community, a total of 318 AFLP, 121 SSR, 108 RFLP, and 126 STS markers were newly developed and integrated into the framework of the previously described linkage map. …”
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    An Integrated High-density Linkage Map of Soybean with RFLP, SSR, STS, and AFLP Markers Using A Single F(2) Population
  11. 51111
    “…There was a strong relationship between urbanisation status, from RR to RU to UR to UU, and personal income, availability of modern home appliances, car ownership, consumption of ‘junk food’ and physical inactivity. …”
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    Associations between urbanisation and components of the health-risk transition in Thailand. A descriptive study of 87,000 Thai adults
  12. 51112
    “…The treatment for various histological subtypes leading to nephrotic syndrome is different, and in this modern era we should practice evidence-based medicine and should avoid empirical therapy with its associated adverse effects.…”
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    Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature
  13. 51113
    “…The Audit and Best practice for Chronic Disease Extension (ABCDE) project has facilitated the implementation of modern Continuous Quality Improvement (CQI) approaches in Indigenous community health care centres across Australia. …”
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    Study protocol: national research partnership to improve primary health care performance and outcomes for Indigenous peoples
  14. 51114
    “…Exploiting the full potential of gene sequences becoming available for V. destructor requires adaptation of modern molecular biology approaches to this non-model organism. …”
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    Gene-knockdown in the honey bee mite Varroa destructor by a non-invasive approach: studies on a glutathione S-transferase
  15. 51115
    “…Moreover, ancestry is a critical factor in assessing lifetime risk of disease, and can play an important role in optimizing treatment. As modern medicine moves towards using personal genetic information for clinical applications, it is important to determine genetic ancestry in an accurate, cost-effective and efficient manner. …”
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    CoAIMs: A Cost-Effective Panel of Ancestry Informative Markers for Determining Continental Origins
  16. 51116
    “…Bayesian analysis showed that the most recent common ancestor for modern HEV existed between 536 and 1344 years ago. …”
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    Evolutionary History and Population Dynamics of Hepatitis E Virus
  17. 51117
    “…BACKGROUND: Genetic markers are pivotal to modern genomics research; however, discovery and genotyping of molecular markers in oat has been hindered by the size and complexity of the genome, and by a scarcity of sequence data. …”
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    Model SNP development for complex genomes based on hexaploid oat using high-throughput 454 sequencing technology
  18. 51118
    “…BACKGROUND: As a response to a changing operating environment, healthcare administrators are implementing modern management tools in their organizations. The balanced scorecard (BSC) is considered a viable tool in high-income countries to improve hospital performance. …”
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    Understanding the context of balanced scorecard implementation: a hospital-based case study in pakistan
  19. 51119
    “…Combined radioimmunotherapy with cetuximab as well as modern radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) and carbon ion therapy (C12) are able to limit toxicity while maintaining treatment effects. …”
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    Online Artículo Texto
    Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx - TPF-C-HIT
  20. 51120
    “…CONCLUSIONS: The highly conserved synteny between fish and tetrapod transferrin loci infers that the fusion of tandem duplicated Omp-like genes gave rise to the modern transferrins. The multiple nonsynonymous substitutions in cod Tf1 with putative structural effects, together with highly divergent allele frequencies among different cod populations, strongly suggest evidence for positive selection and local adaptation in trans-Atlantic cod populations.…”
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    Polymorphism, selection and tandem duplication of transferrin genes in Atlantic cod (Gadus morhua) - Conserved synteny between fish monolobal and tetrapod bilobal transferrin loci
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