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53021“…Our findings suggest that the molecular machinery and mechanisms for executing Bcl-2-mediated apoptosis as observed in mammals are evolutionary ancient, with early regulation of apoptotic machineries closely resembling their modern counterparts in mammals rather than Caenorhabditis elegans or drosophila.…”
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53022por Sewerin, Philipp, Vordenbaeumen, Stefan, Hoyer, Annika, Brinks, Ralph, Buchbender, Christian, Miese, Falk, Schleich, Christoph, Klein, Sabine, Schneider, Matthias, Ostendorf, Benedikt“…BACKGROUND: Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). …”
Publicado 2017
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53023“…They are major contributors to modern terrestrial ecosystems, and have a deep evolutionary history. …”
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53024por Sporny, Michael, Guez-Haddad, Julia, Kreusch, Annett, Shakartzi, Sivan, Neznansky, Avi, Cross, Alice, Isupov, Michail N., Qualmann, Britta, Kessels, Michael M., Opatowsky, Yarden“…Consistently, SRGAP2A:SRAGP2C hetero-dimers form, but are insoluble, inhibiting SRGAP2A activity. 4) Inactivation of SRGAP2A is sensitive to the level of hetero-dimerization with SRGAP2C. 5) The primal form of SRGAP2C (P-SRGAP2C, existing between ∼3.4 and 2.4 Ma) is less effective in hetero-dimerizing with SRGAP2A than the modern SRGAP2C, which carries several substitutions (from ∼2.4 Ma). …”
Publicado 2017
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53025por Habib, Muhammad Atif, Raynes-Greenow, Camille, Nausheen, Sidrah, Soofi, Sajid Bashir, Sajid, Muhammad, Bhutta, Zulfiqar A, Black, Kirsten I“…Integrated national family program that provides contraceptive services especially the modern methods to women during pre-conception and post-partum would be beneficial in averting unintended pregnancies and their related adverse outcomes in Pakistan…”
Publicado 2017
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53026“…In order to develop a more complete understanding of labour pain, this study aimed to examine women’s experiences within the perspective of modern pain science. A more complete understanding of this phenomenon can then guide the development of interventions to enhance women’s experiences and potentially reduce their need for pharmacological intervention. …”
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53027por Cieslak, Jakub, Wodas, Lukasz, Borowska, Alicja, Cothran, Ernest G., Khanshour, Anas M., Mackowski, Mariusz“…Five haplotypes were putatively novel while the remaining 14 showed the 100% homology with sequences deposited in the GenBank database, represented by both modern and primitive horse breeds. Generally, comparisons found the haplotypes conformed to 10 different recognized mtDNA haplogroups (A, B, E, G, J, M, N, P, Q and R). …”
Publicado 2017
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53028“…Both oral stories and those told through technology were described as the ‘modern birth story’. The first theme ‘Stories are difficult like that’, examines the birth story as problematic and considers how stories shape meaning. …”
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53029por Shorinola, Oluwaseyi, Balcárková, Barbara, Hyles, Jessica, Tibbits, Josquin F. G., Hayden, Matthew J., Holušova, Katarina, Valárik, Miroslav, Distelfeld, Assaf, Torada, Atsushi, Barrero, Jose M., Uauy, Cristobal“…We identified the non-dormant TaMKK3-A allele at low frequencies within the A-genome diploid progenitor Triticum urartu genepool, and show an increase in the allele frequency in modern varieties. In United Kingdom varieties, the frequency of the dormant TaMKK3-A allele was significantly higher in bread-making quality varieties compared to feed and biscuit-making cultivars. …”
Publicado 2017
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53030por Eijlers, Robin, Legerstee, Jeroen S, Dierckx, Bram, Staals, Lonneke M, Berghmans, Johan, van der Schroeff, Marc P, Wijnen, Rene MH, Utens, Elisabeth MWJ“…The tool could create a less stressful experience for both children and their parents, in line with the modern emphasis on patient- and family-centered care. …”
Publicado 2017
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53031por Traylor, Matthew, Curtis, Charles, Patel, Hamel, Breen, Gerome, Hyuck Lee, Sang, Xu, Xiaohui, Newhouse, Stephen, Dobson, Richard, Steer, Sophia, Cope, Andrew P., Markus, Hugh S., Lewis, Cathryn M., Scott, Ian C.“…Gene–environment RA risk factors identified in European/Asian ancestry populations are relevant in African ancestry individuals. As modern statistical methods facilitate analysing ancestrally diverse populations, future genetic studies should incorporate African ancestry individuals to ensure their implications for precision medicine are universally applicable.…”
Publicado 2017
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53032por Guan, Huan-yu, Li, Peng-fei, Wang, Xiao-ming, Yue, Jia-jing, He, Yang, Luo, Xiao-mei, Su, Mei-feng, Liao, Shang-gao, Shi, Yue“…Shengjiang Xiexin decoction (SXD), a classic traditional Chinese medical formula chronicled in Shang Han Lun, is used in modern clinical practice to decrease gastrointestinal toxicity induced by the chemotherapeutic drug irinotecan (CPT-11). …”
Publicado 2017
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53033por Reau, Nancy, Robertson, Michael N., Feng, Hwa‐Ping, Caro, Luzelena, Yeh, Wendy W., Nguyen, Bach‐Yen T., Wahl, Janice, Barr, Eliav, Hwang, Peggy, Klopfer, Stephanie O.“…Concomitant proton pump inhibitor (PPI) use reduces plasma concentrations of certain nonstructural protein 5A inhibitors, which are key components of modern hepatitis C infection (HCV) treatments. These reduced concentrations may decrease efficacy, leading to challenging treatment failures due to the development of resistance‐associated substitutions. …”
Publicado 2017
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53034por Zimmermann, Johannes B., Pinder, Nadine, Bruckner, Thomas, Lehmann, Monika, Motsch, Johann, Brenner, Thorsten, Hoppe-Tichy, Torsten, Swoboda, Stefanie, Weigand, Markus A., Hofer, Stefan“…BACKGROUND: Severe sepsis and septic shock remain a major challenge, even in modern intensive care. In Germany, about 68,000 patients die annually because of septic diseases, characterized by a complex systemic inflammatory response. …”
Publicado 2017
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53035“…Birth Before Arrival (BBA) is a preventable phenomenon still common in modern-day practice despite extensive improvements made in obstetric care and in accessibility to healthcare in South Africa. …”
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53036por Li, Jiawei, Zeng, Wen, Zhang, Ye, Ko, Albert Min-Shan, Li, Chunxiang, Zhu, Hong, Fu, Qiaomei, Zhou, Hui“…We compared Mogou to 7 other ancient and 38 modern Chinese groups, in a total of 1793 individuals, and found that Mogou shared close genetic distances with Taojiazhai (a more recent Di-Qiang population), Hengbei, and Northern Han. …”
Publicado 2017
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53037por Kruizinga, Renske, Scherer-Rath, Michael, Schilderman, Johannes B. A. M., Weterman, Mariëtte, Young, Teresa, van Laarhoven, Hanneke W. M.“…The development of a new language which more naturally expresses different images of a higher being amongst patients in western late-modern societies may further aid our understanding and subsequently lead to an improvement in patients’ spiritual wellbeing.…”
Publicado 2017
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53038“…Taste and aroma were the major sociocultural reasons behind using WEP while modernization and changing lifestyle were the main reasons behind declining use of WEP. …”
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53039por Winston, Jennifer, Calhoun, Lisa M., Corroon, Meghan, Guilkey, David, Speizer, Ilene“…BACKGROUND: The 2012 London Summit on Family Planning set ambitious goals to enable 120 million more women and adolescent girls to use modern contraceptives by 2020. The Urban Reproductive Health Initiative (URHI) was a Bill & Melinda Gates Foundation funded program designed to help contribute to these goals in urban areas in India, Kenya, Nigeria, and Senegal. …”
Publicado 2018
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53040“…In many developing countries, modern fuels are more and more used alongside traditional ones, mainly in urban area. …”
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