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  1. 53481
    “…The evidence on treating older patients with psoriasis with modern biologics is scarce. This study compared the efficacy and safety of tildrakizumab among younger and older patients with psoriasis (< 65/≥ 65 years) in a post hoc analysis of 2 phase III trials (reSURFACE1/2, n = 1,862). …”
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    Efficacy and Safety of Tildrakizumab in Older Patients: Pooled Analyses of Two Randomized Phase III Clinical Trials (reSURFACE 1 and reSURFACE 2) Through 244 Weeks
  2. 53482
    “…Although none of the commercially available penile prosthesis devices in the United States are designed for phalloplasty, modern inflatable and malleable prostheses are adapted for use in the post-phalloplasty setting. …”
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    Penile and testicular prosthesis following gender-affirming phalloplasty and scrotoplasty: a narrative review and technical insights
  3. 53483
    “…SIMPLE SUMMARY: Understanding differential mechanisms of the subcutaneous adipose tissue between indigenous breeds and modern pig breeds is important. After transcriptome sequencing and liposome detection of the subcutaneous adipose tissue in Ningxiang pigs, Berkshires and F(1) offspring, we retrieved differentially expressed genes (DEGs) and significantly changed lipids (SCLs) in different groups. …”
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    Integrative Analysis of Transcriptomic and Lipidomic Profiles Reveals a Differential Subcutaneous Adipose Tissue Mechanism among Ningxiang Pig and Berkshires, and Their Offspring
  4. 53484
    “…IMPORTANCE: Petroleum pollution in the ocean has increased because of rapid population growth and modernization, requiring urgent remediation. Our understanding of the metabolic response of native microbial communities to oil spills is not well understood. …”
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    Exploring novel alkane-degradation pathways in uncultured bacteria from the North Atlantic Ocean
  5. 53485
    “…BACKGROUND: Accelerated modern industrial processes, extensive use of pesticides and fertilizers and remaining issues of wastewater irrigation have led to an increasingly severe composite pollution of heavy metals in arable land. …”
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    Health risk assessment of heavy metal pollution and its sources in agricultural soils near Hongfeng Lake in the mining area of Guizhou Province, China
  6. 53486
    “…SIMPLE SUMMARY: Modern dairy cattle farms have intensified greatly in recent years to meet the increased global demand for fresh milk. …”
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    A Cross-Sectional Study of Risk Factors Affecting Milk Quality in Dairy Cows
  7. 53487
    “…Salinity is considered to be a global problem and a severe danger to modern agriculture since it negatively impacts plants’ growth and development at both cellular- and whole-plant level. …”
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    Cobalt and Titanium Alleviate the Methylglyoxal-Induced Oxidative Stress in Pennisetum divisum Seedlings under Saline Conditions
  8. 53488
    por Srikanth, V S
    Publicado 2023
    “…WHO World Malaria Day theme is “Harness innovation to reduce the malaria disease burden and save lives” which is the only way to eradicate malaria by using modern technologies. We used remotely piloted aircraft and quadcopters for effective malaria surveillances and also created a task force DMSEU (Drone Malaria Surveillance and eradication unit). …”
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    1404. Remotely Piloted Aircraft & Quadcopters used in Combating Malaria/Dengue in desert terrain
  9. 53489
    “…BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is associated with substantial morbidity and mortality, and modern medicine offers less effective treatment for HFpEF. …”
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    Efficacy of Chinese traditional patent medicines for heart failure with preserved ejection fraction: a Bayesian network meta-analysis of 64 randomized controlled trials
  10. 53490
    “…It appears that great confidence in modern medical science does not stimulate many changes in life style. …”
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    GPs' perspectives of type 2 diabetes patients' adherence to treatment: A qualitative analysis of barriers and solutions
  11. 53491
    “…The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep deprived. …”
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    Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates
  12. 53492
    “…BACKGROUND: Modern biology has shifted from "one gene" approaches to methods for genomic-scale analysis like microarray technology, which allow simultaneous measurement of thousands of genes. …”
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    GeneTools – application for functional annotation and statistical hypothesis testing
  13. 53493
    por Berman, Jules J
    Publicado 2003
    “…BACKGROUND: Large biomedical data sets have become increasingly important resources for medical researchers. Modern biomedical data sets are annotated with standard terms to describe the data and to support data linking between databases. …”
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    A tool for sharing annotated research data: the "Category 0" UMLS (Unified Medical Language System) vocabularies
  14. 53494
    por Perera, B
    Publicado 1999
    “…INTRODUCTION: With the roll out of the NHS computerisation programme, hospital intranets have come into operation in the last two to three years but wards and departments were unable to log on to the Intranet because of old / obsolete hardware that was still in use. Recently modern equipment has been installed at numerous sites, especially wards, making the intranet more accessible. …”
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    MED12/376: Microbiology and the Hospital Intranet
  15. 53495
    por Bludau, HB, Vocke, A, Herzog, W
    Publicado 1999
    “…MOTIVATION: According to the Federal Ministry the avowed target of modern medicine is to administer the best medical care, the newest scientific insights and the knowledge of experienced specialists on affordable conditions to every patient no matter whether he is located in a rural area or in a teaching hospital. …”
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    HIN9/468: The Last Mile - Secure and mobile data processing in healthcare
  16. 53496
    “…BACKGROUND: The concept of acupuncture point localisation in Traditional Chinese Medicine (TCM) is based on millenary practical experience. Modern imaging methods such as PET, MRI and SPECT have been used primary for the investigation of the mechanisms of action of acupuncture. …”
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    In-vivo visualisation of the anatomical structures related to the acupuncture points Dai mai and Shen mai by MRI: A single-case pilot study
  17. 53497
    por Merkl, Rainer
    Publicado 2007
    “…Most plausibly, trpB2 represents the predecessor of the modern trpB gene, and trpB1 evolved in an ancestral bacterium. …”
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    Modelling the evolution of the archeal tryptophan synthase
  18. 53498
    “…Of vital importance for refined clinical practice and improved intervention strategies is to define the hidden molecular distinct diseases using modern large-scale genomic approaches. Microarray omics technology has provided a powerful way to dissect hidden genetic heterogeneity of complex diseases. …”
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    Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering
  19. 53499
    “…CONCLUSION: Overall, these results suggest that natural selection has acted on codon usage in the genus Drosophila, at least often enough to leave a footprint of selection in modern genomes. However, there is evidence in the data that random forces (drift and mutation) have also left patterns in the data, especially in genes under weak selection for codon usage for example genes in regions of low recombination. …”
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    Codon usage in twelve species of Drosophila
  20. 53500
    “…BACKGROUND: Target identification is important for modern drug discovery. With the advances in the development of molecular docking, potential binding proteins may be discovered by docking a small molecule to a repository of proteins with three-dimensional (3D) structures. …”
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    PDTD: a web-accessible protein database for drug target identification
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