“…BACKGROUND: Section 114 of the 1997 Food and Drug Administration Modernization Act (FDAMA) effective February 19, 1998, permitted some additional flexibility for drug companies to provide health care economic information to a formulary committee or other similar entity and may have caused a decline in economic messages used in print advertisements in medical journals. …”
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“…One of the factors determining the most optimal management tactics is based on the pathophysiological mechanism of GDM formation. According to modern concepts, the processes associated with pancreatic β-cell dysfunction, insulin resistance (IR) or a combination of these factors may prevail in the basis of the formation of GDM, forming various subtypes of GDM. …”
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“…The frequency of SS has declined in developed countries as the result of modern obstetric care. It may present immediately after delivery or many years later with delay up to 32 years after the inciting event.(1) SS is characterized by anterior pituitary dysfunction, while diabetes insipidus (DI) is an uncommon complication with an estimated frequency of 5%.(2) Here, we present a case of a 58-year-old woman with late onset SS 33 years after delivery, complicated by DI. …”
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“…Radiolucent lines were documented using the Modern Knee Society Radiographic System. Five-year survival was assessed using Kaplan–Meier analysis with the Log Rank method to determine statistical significance. …”
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“…Thus, notwithstanding the numerous gene exchanges and acquisitions attributed to later stages of evolution, most, if not all, modern viruses and other selfish agents are inferred to descend from elements that belonged to the primordial genetic pool. …”
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“…This biphasic model of evolution is substantially analogous to the scenario of the origin of universes in the eternal inflation version of modern cosmology. Under this model, universes like ours emerge in the infinite multiverse when the eternal process of exponential expansion, known as inflation, ceases in a particular region as a result of false vacuum decay, a first order phase transition process. …”
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“…Using a specifically formulated silicon-depleted diet and modern methods for silicon analysis and assessment of skeletal development, we undertook, through international collaboration between silicon researchers, an extensive study of long-term silicon depletion on skeletal development in an animal. 21-day old female Sprague–Dawley rats (n = 20) were fed a silicon-depleted diet (3.2 µg Si/g feed) for 26 weeks and their growth and skeletal development were compared with identical rats (n = 10) on the same diet but with silicon added as Si(OH)(4) to their drinking water (53.2 µg Si/g water); total silicon intakes were 24 times different. …”
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“…Questions are thus raised about the characteristics and composition of weapons now being deployed in modern battlefields…”
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“…INTRODUCTION: The difference between modern lifestyle in urban areas and the traditional way of life in rural areas may affect the population's health in developing countries proportionally. …”
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“…We argue that the evolutionarily young morphological radiation of Clermontia may form a model system for general understanding of mechanisms of larger-scale angiosperm diversification in past, similarly unstable environments, in which small regulatory changes may have been responsible for modern-day groundplan differences. TRIAL REGISTRATION: Clinical Trials.gov- NCT01710735 SIGNIFICANCE AND INNOVATIONS: The present investigation is one of the first to examine the hypothesis of gross muscle contractile inhibition due to the presence of diagnostically relevant MFTrPs. …”
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“…We introduce extensions of DAD to handle rich cluster interactions and diverse data distributions. INTRODUCTION: Modern biosurveillance data contains thousands of unique time series defined across various categorical dimensions (zipcode, age groups, hospitals). …”
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“…Classical TEM serial section investigations are extremely time consuming, and modern methods for 3D analysis of ultrastructure such as SBF-SEM and FIB-SEM are limited to very small volumes for examination. …”
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“…The logic behind such correlation is based on the fact that, like other physiological processes, B.P. too is normal phenomenon of our body which is governed by Tridosha. After going through modern pathogenesis of primary hypertension and its symptomology, in present study it has been correlated with Vata Kaphaja Vikara with Rasavaha, Raktavaha and Manovahi Srotas as the seat of disease. …”
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“…Use of medications, both traditional and modern, increased from baseline to follow-up, with no differentiation in use by intervention area. …”
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“…Shaped by environmental factors, such variants influence the genetics of modern health, disease, and treatment outcome. Because evolutionary processes tend to act on gene regulation, we test whether regulatory variants are under positive selection. …”
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“…Department of Transportation approached the National Institute of Standards and Technology (NBS became NIST in 1988) and requested that the data from this study be reexamined to determine if the information handling and analysis capabilities of modern computers and software could enable the extraction of more meaningful information from these data. …”
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“…However, on the basis of the results of this study, we could speculate that the conclusions of the meeting were somewhat misleading or at least misinterpreted, as they were based on surgical techniques and rehabilitation procedures no more in use in the modern ACL surgery.…”
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“…The breed in the USA started from a small number of founders from Europe and has remained relatively isolated and small in numbers, limiting breeding choices especially in the period before modern transportation and artificial insemination. …”
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“…INTRODUCTION: Soft denture liners have a key role in modern removable prosthodontics since they restore health to inflamed and abused mucosa by redistribution of forces transmitted to the edentulous ridges. …”
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“…This study sought to analyze the impact of demographics, histology, clinical presentation, and treatments on the clinical outcomes of UM in a large modern nationwide patient cohort. METHODS: Demographics and clinical data were abstracted on 277,120 histologically confirmed melanoma patients from the Surveillance, Epidemiology, and End Results database between 1973 and 2012. …”
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