“…The effector phenotype of co-cultured CD8+ T cells exemplified by expression of activation markers and release of effector molecules was rather enhanced by PDAC macrophage spheroids, particularly with M1-like macrophages compared to mono-culture spheroids. However, this was not associated with enhanced PDAC cell death. …”
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“…Furthermore, ex vivo culture of isolated LGR5+ cells from tumors of co‐engrafted mice formed significantly larger size of organoids than mono‐engrafted. Our results also indicated significantly larger size and number of formed organoids, when LGR5+ cells co‐cultured with CAF in both cell–cell contact and paracrine signaling in vitro, comparing to LGR5+ cells alone. …”
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“…These included the medium chain, long chain saturated (palmitate [16:0]), long chain mono- and polyunsaturated (nisinate [24:6n3]). In conjunction with this, the levels of acylcarnitines are lower as well. …”
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“…In bovine ovaries, the cortex, housing PMFs, is 8.5 times more rigid than deep medulla and is comprised of differential matrisome proteins. As mono-ovulatory animals, their ovaries closely mimic humans, making them a suitable model. …”
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“…Data can be fitted by simple mono-exponential conversion kinetics, with lifetimes τ in the 14–38 h range. …”
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“…Slide microscopy (the reference standard) diagnosed 213 Plasmodium vivax (Pv) monoinfections, 98 Plasmodium falciparum (Pf) mono-infections and no malaria in 650 cases. The sensitivities (sens) and specificities (spec), of the RDTs for the detection of malaria were- CareStart Malaria™ pLDH (Pan) test: sens 89.1% [CI(95 )84.2-92.6], spec 97.6% [CI(95 )96.5-98.4] OptiMal-IT(®): Pf+/- other species detection: sens 95.2% [CI(95 )87.5-98.2], spec 94.7% [CI(95 )93.3-95.8]; non-Pf detection alone: sens 89.6% [CI(95 )83.6-93.6], spec 96.5% [CI(95 )94.8-97.7] CareStart Malaria™ pLDH (Pan, Pf): Pf+/- other species: sens 93.5% [CI(95)85.4-97.3], spec 97.4% [95.9-98.3]; non-Pf: sens 78.5% [CI(95)71.1-84.4], spec 97.8% [CI(95 )96.3-98.7] Inter-observer agreement was excellent for all tests (kappa > 0.9). …”
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“…Retinal, an immediate precursor of retinoids, is derived by β-carotene 15,15'-mono(di)oxygenase (BCM(D)O) from β-carotene, which is synthesized from the isoprenoid building blocks isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). …”
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“…Combined radionuclide therapy with bisphosphonates has demonstrated improved effectiveness in achieving bone pain palliation in comparison to mono therapy with radionuclides or bisphosphonates alone. …”
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“…BACKGROUND: Whilst exogenous carbohydrate oxidation (CHO(EXO)) is influenced by mono- and disaccharide combinations, debate exists whether such beverages enhance fluid delivery and exercise performance. …”
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“…BACKGROUND: HIV infection leads to a faster progression of liver disease in subjects infected with HCV, as compared with HCV mono-infected patients. Previous reports suggest that sustained virological response (SVR) rates are lower in HIV/HCV coinfection than in HCV monoinfection. …”
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“…In contrast, the response rate at week 96 during DRV/r QD mono-therapy was non-inferior to that of triple PI/r-based ARV therapy. …”
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“…Congenic C57BL/6J (B6-Mx1(r/r)) mice expressing a wild-type allele from the A2G mouse strain are highly resistant to influenza A virus infections, to both mono- and polybasic subtypes. Furthermore, in genetic mapping studies, Mx1 was identified as the major locus of resistance to influenza virus infections. …”
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“…En analyse univariée l'âge, la dyspnée de stade III et IV, l'insuffisance cardiaque, la présence d'un infarctus du myocarde, d'une coronaropathie mono et bitronculaire, les anomalies du doppler de trons supra-aortique et du membre inférieur, le caractère urgent de la chirurgie, la durée de la circulation extracorporelle, l'instabilité hémodynamique postopératoire, le saignement et l'insuffisance rénale postopératoire étaient statistiquement associés à une mortalité postopératoire élevée. …”
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“…MAIN RESULTS AND THE ROLE OF CHANCE: Male germ cells, present in testicular tissue pieces grown from 5 dpp rats, exhibited positive protein expression for Acrosin and Crem (cAMP (cyclic adenosine mono phosphate) response element modulator) after 52 days of culture in vitro. …”
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“…Apoptosis was measured by quantifying mono- and oligonucleosomes in the cytoplasmic fraction of cell lysates. …”
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“…The chemosensitizing role of curcumin might attribute to the autophagy turnover from being activated in 5-Fu mono-treatment to being inhibited in the pre-Cur treatment as indicated by the changes in expression of beclin-1, p62 and LC3II/LC3I and the intensity of Cyto-ID Green staining. …”
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“…Flow cytometric measurements were performed to evaluate levels of apoptosis based on mono- or combination treatments. The best combination was used for in vivo combination therapy studies in nude mice with SKOV3ip and IGROV1 human ovarian cancer xenografts. …”
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“…Of the phthalates, only mono-n-butyl phthalate (MnBP) was associated with lower hCG-alpha (-0.14 log units, 95% CI -0.3, 0.1), higher FT4 (1.11 pmol/l, 95% CI 0.5, 1.8) in females, and infant cognition to year 3 (-0.11 log units in females, 95% CI -0.2, 0.0). …”
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“…A profound gut dysbiosis characterized virally infected pts, especially HCV+/HIV+ co-infected patients, delineating a Firmicutes-poor/Bacteroidetes-rich microbiota, with significant associations with MAIT cell frequency/function. Irrespective of mono/dual infection, HIV+ and HCV+ patients display depleted, yet activated/cytolytic MAIT cells with reduced ex vivo function, suggesting an impoverished pool, possibly due to continuous bacterial challenge. …”
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“…There was no apparent relationship between ECR and age, gender, renal status, SIRS, PORT, prior antibiotic use, baseline pathogens, typical/atypical pathogens, or mono/polymicrobial pathogens. The high percentage of patients at LFU with baseline symptom resolution suggests that symptom resolution was sustained. …”
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