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  1. 12121
    “…MÉTHODES: Il s’agit d’une étude continue mono-centrique observationnelle. Tous les patients ayant nécessités une prise en charge chirurgicale traumatologique entre le 20 mars et le 20 avril 2020 ont été inclus, et les données de la même période de 2019 étaient récupérées. …”
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    L’épidémie de fractures de l’extrémité proximale du fémur n’a pas diminué pendant la pandémie COVID-19 : résultats d’une étude observationnelle()
  2. 12122
    “…Here we show that in cervical cancer biopsies the stabilization of Cdt2 in the HPV-induced cancers leads to the decrease of a CRL4-Cdt2 substrate, the histone H4K20 mono-methyltransferase Set8, and decrease in H4K20me1 or H4K20me3 that can be detected by immunohistochemistry. …”
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    HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
  3. 12123
    “…Although men and women responded similarly to both ICI mono- and ICI-CHT treatment, predictors of response differed by sex.…”
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    Sex-Based Clinical Outcome in Advanced NSCLC Patients Undergoing PD-1/PD-L1 Inhibitor Therapy—A Retrospective Bi-Centric Cohort Study
  4. 12124
    “…Based on the above observation, an accurately calculated amount of black soldier fly larvae could be formulated into aquafeed as the main source of saturated fatty acids and partial source of mono-unsaturated and poly-unsaturated fatty acids to save fish oil.…”
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    Growth and Fatty Acid Composition of Black Soldier Fly Hermetia illucens (Diptera: Stratiomyidae) Larvae Are Influenced by Dietary Fat Sources and Levels
  5. 12125
    “…La proportion de PSC était de 49 % dans les séquences multi-séjours et de 22 % dans les séquences mono-séjour. La durée médiane des séquences était de 15 jours si PSC et de 8 jours sinon. …”
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    Mise en place d'un algorithme de chaînage pour l'analyse en séquences de soins des séjours COVID dans la base nationale PMSI (Programme de médicalisation des systèmes d'information), étude COVIDIM
  6. 12126
    “…Administration of neuregulin 1 beta (NRG1β) significantly affected neither cellular proliferation nor the basal migratory ability of basal-like/triple-negative quasi-normal MCF10A breast cells, cultured in mono-layer conditions. Furthermore, no significant regulation in cell morphology or in the expression of basal/myoepithelial and luminal markers was observed upon stimulation with NRG1β. …”
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    NRG1/ERBB3/ERBB2 Axis Triggers Anchorage-Independent Growth of Basal-like/Triple-Negative Breast Cancer Cells
  7. 12127
    “…Blood smears results were exclusively positive for P. falciparum, whereas RT-PCR also detected P. malariae and P. ovale mono- and co-infections. Submicroscopic infection prevalence was associated with topographical variation (χ(2) = 39.344, df = 2, p<0.0001). …”
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    Risk associations of submicroscopic malaria infection in lakeshore, plateau and highland areas of Kisumu County in western Kenya
  8. 12128
    “…The rates of drug-resistant (DR)-TB, mono-resistant TB, multidrug resistant (MDR)-TB, polydrug resistant TB in G(1,) G(2), G(3) and G(0) were 19.24%/16.4%/17.33%/19.08%, 11.52%/8.68%/10.94%/11.63%, 3.03%/2.57%/2.96%/3.66% and 4.70%/4.82%/3.34%/ 4.08%, respectively. …”
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    Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020
  9. 12129
    “…Because DSF uncouples p97 from Nploc4, we treated atrophying myotubes with DSF, and found accumulated mono and polyubiquitinated proteins and reduced degradation of long‐lived proteins by 35% (P ≤ 0.0001), including actin (P ≤ 0.05). …”
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    The p97‐Nploc4 ATPase complex plays a role in muscle atrophy during cancer and amyotrophic lateral sclerosis
  10. 12130
    “…Rnf20 and Rnf40, exist as homodimeric or heterodimeric complexes to deposit a mono-ubiquitin epigenetic mark on histone (H)2B (i.e., H2Bub1) and regulate gene transcription as a precursor to active H3K4 trimethylation (H3K4me3) and H3K79 methylation (H3K79me) marks. …”
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    RF04 | PSUN133 Assessment of the Rnf20 Histone Modifier in Regulating Pancreatic Beta-Cell Identity and Function
  11. 12131
    “…Coinfection occurred more commonly in younger children with a median age of 1.2 (0.0, 4.5) compared to those with mono-infection with a median age of 6 (1.0, 14.0) (p < 0.001). …”
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    Severe COVID-19 outcomes in pediatrics: an observational cohort analysis comparing Alpha, Delta, and Omicron variants
  12. 12132
    por Mountzios, Giannis, Planchard, David, Metro, Giulio, Tsiouda, Dora, Prelaj, Arsela, Lampaki, Sofia, Shalata, Walid, Riudavets, Mariona, Christopoulos, Petros, Girard, Nicolas, Albarrán-Artahona, Víctor, Garcia Campelo, Rosario, Samitas, Konstantinos, Banna, Giuseppe Luigi, Boukovinas, Ioannis, Agbarya, Abed, Koumarianou, Anna, Perdikouri, Eleni-Isidora, Kosmidis, Paris, Linardou, Helena, Mauri, David, Mavroudis, Dimitrios, Athanasiadis, Ilias, Kalofonos, Haralambos, Xenidis, Nikolaos, Korantzis, Ippokratis, Ardavanis, Alexandros, Rallis, Grigorios, Bottiglieri, Achille, Efthymiadis, Konstantinos, Oikonomopoulos, Georgios, Kokkalis, Alexandros, Saloustros, Emmanouil, Tsoukalas, Nikolaos, Bartzi, Dimitra, Economopoulou, Panagiota, Psyrri, Amanda, Reck, Martin, Lo Russo, Giuseppe
    Publicado 2022
    “…Treatment on mutation identification included chemotherapy (CT) (33.8%), CT-immunotherapy (IO) (18.2%), osimertinib (22.1%), poziotinib (9.1%), mobocertinib (6.5%), mono-IO (3.9%), and amivantamab (1.3%). Disease control rates were 66.2% with CT plus or minus IO, 55.8% with osimertinib, 64.8% with poziotinib, and 76.9% with mobocertinib. …”
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    Molecular Epidemiology and Treatment Patterns of Patients With EGFR Exon 20-Mutant NSCLC in the Precision Oncology Era: The European EXOTIC Registry
  13. 12133
    “…METHODS: Patients aged 13–65 years with confirmed mono-infection of P. vivax along with fever or fever in the previous 48 h were included. …”
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    Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study
  14. 12134
    “…Eligibility criteria were (1) adults (age ≥18 years), (2) Latino birth or ancestry, (3) speaks Spanish (mono- or multilingual), and (4) on antiretrovirals. …”
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    Linguistic and Cultural Adaptation of a Computer-Based Counseling Program (CARE+ Spanish) to Support HIV Treatment Adherence and Risk Reduction for People Living With HIV/AIDS: A Randomized Controlled Trial
  15. 12135
    “…The majority of subjects (90.2%) were on ART with 79% of the cohort having an undetectable HIV-RNA (< 40 copies/ml) and the time since ART initiation was 7.5 (3.7–10.4) year. rs368234815 and rs12979860 displayed similar allelic frequencies, with minor alleles ΔG and T representing 39% and 42%, respectively, of circulating alleles. rs368234815 ΔG/ΔG minor homozygotes were significantly associated with increased odds for attaining a normalised CD4(+):CD8(+) ratio compared to rs368234815 T/T major homozygotes in PLWH virologically suppressed on effective ART (OR = 3.11; 95% CI [1.01:9.56]). rs368234815 ΔG/ΔG homozygosity was also significantly associated with lower levels of CD4(+) effector memory T-cells (regression coefficient: − 7.1%, p = 0.04) and CD8(+) naïve T-cell subsets were significantly higher in HIV-1 mono-infected PLWH with rs368234815 ΔG/ΔG (regression coefficient: + 7.2%, p = 0.04). …”
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    Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4(+):CD8(+) T-cell ratio in treated HIV-1 infection
  16. 12136
    “…Analyzed Lys metabolites were the post-translational modification (PTM) products N(ε)-mono-, di- and trimethyllsine, N(ε)-MML, N(ε)-DML, N(ε)-TML, respectively, N(α)-ML, N(ε)-AcL, N(α)-AcL, and its advanced glycation end-products (AGEs) N(ε)-CML, N(ε)-CM-[2,4,4-(2)H(3)]Lys (d(3)-CML), N(ε)-CEL and furosine. …”
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    Development, validation of a GC–MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special emphasis to lysine
  17. 12137
    “…METHODS: A 77-member panel of specimens composed of the World Health Organization (WHO) international Plasmodium antigen standards, cultured parasites for P. falciparum and Plasmodium knowlesi, and clinical specimens with mono-infections for P. falciparum, Plasmodium vivax, and Plasmodium malariae was generated as both whole blood and dried blood spot (DBS) specimens. …”
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    Comparison of two malaria multiplex immunoassays that enable quantification of malaria antigens
  18. 12138
    “…METHODS: Data were extracted from a register of South African drug-resistant-tuberculosis (DR-TB) patients (Electronic DR-TB Register [EDRWeb]) for newly diagnosed patients with MDR-TB (including pre-extensively drug-resistant [XDR]-TB and XDR-TB and excluding rifampicin-mono-resistant [RR]-TB, as these patients are by definition not multidrug-resistant), receiving either a bedaquiline-containing or non-bedaquiline-containing regimen, at 14 sites in South Africa. …”
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    Bedaquiline safety, efficacy, utilization and emergence of resistance following treatment of multidrug-resistant tuberculosis patients in South Africa: a retrospective cohort analysis
  19. 12139
    “…STUDY DESIGN, SIZE, DURATION: A prospective mono-center study was conducted with 870 surgical DE cases from a non-university DE expertise center between February 2019 and December 2021. …”
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    Clavien–Dindo, comprehensive complication index and classification of intraoperative adverse events: a uniform and holistic approach in adverse event registration for (deep) endometriosis surgery
  20. 12140
    “…Obeldesivir (ODV), an oral mono-5’-isobutyryl ester prodrug that is metabolized into the same active triphosphate as RDV, is being evaluated in Phase 3 clinical trials. …”
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    545. Remdesivir And Obeldesivir Retain Potent Activity Against SARS-CoV-2 Omicron Variants
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