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242“…INTRODUCTION: Motor neuron disease (MND) is a terminal, progressive, multisystem disorder. …”
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243por de Munck, Estefanía, Palomo, Valle, Muñoz-Sáez, Emma, Perez, Daniel I., Gómez-Miguel, Begoña, Solas, M. Teresa, Gil, Carmen, Martínez, Ana, Arahuetes, Rosa M.“…Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal models for research. Recently, a motor neuron disease animal model has been developed using β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid related to the appearing of ALS. …”
Publicado 2016
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244por Spiller, Krista J., Restrepo, Clark R., Khan, Tahiyana, Stieber, Anna M., Kwong, Linda K., Trojanowski, John Q., Lee, Virginia M.-Y.Enlace del recurso
Publicado 2016
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245por Delva, Aline, Thakore, Nimish, Pioro, Erik P., Poesen, Koen, Saunders‐Pullman, Rachel, Meijer, Inge A., Rucker, Janet C., Kissel, John T., Van Damme, Philip“…Introduction: Disturbances of eye movements are infrequently encountered in motor neuron diseases (MNDs) or motor neuropathies, and there is no known syndrome that combines progressive muscle weakness with downbeat nystagmus. …”
Publicado 2017
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246por Olney, Nicholas T., Bischof, Antje, Rosen, Howard, Caverzasi, Eduardo, Stern, William A., Lomen-Hoerth, Catherine, Miller, Bruce L., Henry, Roland G., Papinutto, Nico“…BACKGROUND: The spectrum of motor neuron disease (MND) includes numerous phenotypes with various life expectancies. …”
Publicado 2018
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247por Ikenaka, Kensuke, Tsukada, Yuki, Giles, Andrew C., Arai, Tadamasa, Nakadera, Yasuhito, Nakano, Shunji, Kawai, Kaori, Mochizuki, Hideki, Katsuno, Masahisa, Sobue, Gen, Mori, IkueEnlace del recurso
Publicado 2019
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248por Mohamed, Ayman A.“…Muscle fatigue is a serious problem in patients with motor neuron diseases (MNDs). It commonly disturbs both daily life activity and rehabilitation tolerance. …”
Publicado 2019
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249por Maunsell, Rose, Bloomfield, Suzanne, Erridge, Clare, Foster, Claire, Hardcastle, Maggi, Hogden, Anne, Kidd, Alison, Lisiecka, Dominika, McDermott, Christopher J, Morrison, Karen, Recio-Saucedo, Alejandra, Rickenbach, Louise, White, Sean, Williams, Peter, Wheelwright, Sally J“…INTRODUCTION: Motor neuron disease (MND) is a progressive, incurable disease, characterised by degeneration of the nerves in the brain and spinal cord. …”
Publicado 2019
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250por Barbalho, Ingridy, Valentim, Ricardo, Júnior, Mário Dourado, Barros, Daniele, Júnior, Hércules Pedrosa, Fernandes, Felipe, Teixeira, César, Lima, Thaísa, Paiva, Jailton, Nagem, Danilo“…BACKGROUND: This article comprises a systematic review of the literature that aims at researching and analyzing the frequently applied guidelines for structuring national databases of epidemiological surveillance for motor neuron diseases, especially Amyotrophic Lateral Sclerosis (ALS). …”
Publicado 2021
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251por Warrier, Manjusha G, Thomas, Priya Treesa, Sadasivan, Arun, Nashi, Saraswati, Vengalil, Seena, Nalini, A.“…Background: The caregivers of persons with motor neuron disease (MND) have several needs that are usually not voiced on any platform. …”
Publicado 2022
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252por Atalar, Ebru, Yurdakul, Fatma Gül, Gök, Kevser, Güler, Tuba, Erten, Şükran, Yaşar, Evren, Bodur, Hatice“…The case is here presented of a 58-year-old female patient who presented with the complaints of increasing pain and weakness in the extremities and was diagnosed with lower motor neuron disease and overlap syndrome. The patient was treated with cyclophosphamide, pulse steroid, hydroxychloroquine and intravenous immunoglobulin. …”
Publicado 2022
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253por Fiorillo, Chiara, Capodivento, Giovanna, Geroldi, Alessandro, Tozza, Stefano, Moroni, Isabella, Mohassel, Payam, Cataldi, Matteo, Campana, Chiara, Morando, Simone, Panicucci, Chiara, Pedemonte, Marina, Brolatti, Noemi, Siliquini, Sabrina, Traverso, Monica, Baratto, Serena, Debellis, Doriana, Magri, Stefania, Prada, Valeria, Bellone, Emilia, Salpietro, Vincenzo, Donkervoort, Sandra, Gable, Kenneth, Gupta, Sita D., Dunn, Teresa M., Bönnemann, Carsten G., Taroni, Franco, Bruno, Claudio, Schenone, Angelo, Mandich, Paola, Nobbio, Lucilla, Nolano, Maria“…Recently, a juvenile form of motor neuron disease has been linked to SPTLC1 variants. …”
Publicado 2022
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254por Parker, Richard A., Weir, Christopher J., Pham, Tra My, White, Ian R., Stallard, Nigel, Parmar, Mahesh K. B., Swingler, Robert J., Dakin, Rachel S., Pal, Suvankar, Chandran, Siddharthan“…BACKGROUND: MND-SMART is a platform, multi-arm, multi-stage, multi-centre, randomised controlled trial recruiting people with motor neuron disease. Initially, the treatments memantine and trazodone will each be compared against placebo, but other investigational treatments will be introduced into the trial later. …”
Publicado 2023
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255por Toh, C., Keslake, A., Payne, T., Onwuegbuzie, A., Harding, J., Baster, K., Hoggard, N., Shaw, P. J., Wilkinson, I. D., Jenkins, T. M.“…BACKGROUND: Magnetic resonance imaging (MRI) of the brain and cervical spinal cord is often performed in diagnostic evaluation of suspected motor neuron disease/amyotrophic lateral sclerosis (MND/ALS). …”
Publicado 2022
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256“…INTRODUCTION: We are undertaking a multicentre randomised controlled trial to determine the effectiveness of including a sleep study (polysomnography, PSG) to assist the commencement of non-invasive ventilation (NIV) in people with motor neurone disease (MND); the PSG4NIVinMND trial. A process evaluation will be conducted alongside the clinical trial. …”
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257“…BACKGROUND: The diagnosis of motor neurone disease (MND) is known to be challenging and there may be delay in patients receiving a correct diagnosis. …”
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258por Stavrou, Maria, Newton, Judith, Stott, Gill, Colville, Shuna, Chandran, Siddharthan, Abrahams, Sharon, Pal, Suvankar, Davenport, Richard“…Cognitive and behavioral abnormalities are recognized as an integral part of Motor Neurone Disease (MND) and occur at all stages of the disease. …”
Publicado 2020
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259“…INTRODUCTION: In motor neuron disease (MND), non-invasive ventilation (NIV) in patients who develop respiratory muscle weakness improves both quality of life and survival. …”
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260por Holdom, Cory J., van Unnik, Jordi W. J., van Eijk, Ruben P. A., van den Berg, Leonard H., Henderson, Robert D., Ngo, Shyuan T., Steyn, Frederik J.“…BACKGROUND: Actigraphy has been proposed as a measure for tracking functional decline and disease progression in patients with Motor Neuron Disease (MND). There is, however, little evidence to show that wrist-based actigraphy measures correlate with functional decline, and no consensus on how best to implement actigraphy. …”
Publicado 2023
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