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401por Joilin, Greig, Gray, Elizabeth, Thompson, Alexander G, Bobeva, Yoana, Talbot, Kevin, Weishaupt, Jochen, Ludolph, Albert, Malaspina, Andrea, Leigh, P Nigel, Newbury, Sarah F, Turner, Martin R, Hafezparast, Majid“…Serum samples from our Oxford Study for Biomarkers in motor neurone disease/amyotrophic lateral sclerosis discovery cohort of amyotrophic lateral sclerosis patients (n = 48), disease mimics (n = 16) and age- and sex-matched healthy controls (n = 24) were profiled for non-coding RNA expression using RNA-sequencing, which showed a wide range of non-coding RNA to be dysregulated. …”
Publicado 2020
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402“…OBJECTIVES: Motor neurone disease (MND) is a progressive, life-limiting illness. …”
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403por Shapiro, Noah L., Todd, Emily G., Billot, Benjamin, Cash, David M., Iglesias, Juan Eugenio, Warren, Jason D., Rohrer, Jonathan D., Bocchetta, Martina“…METHODS: Using an automated segmentation tool for volumetric T1-weighted MR images, we measured hypothalamic regional volumes in a cohort of 439 patients with FTD (197 behavioural variant FTD [bvFTD]; 7 FTD with associated motor neurone disease [FTD-MND]; 99 semantic variant primary progressive aphasia [svPPA]; 117 non-fluent variant PPA [nfvPPA]; 19 PPA not otherwise specified [PPA-NOS]) and 118 age-matched controls. …”
Publicado 2022
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404por Kumfor, Fiona, Liang, Cheng Tao, Hazelton, Jessica L., Leyton, Cristian E., Kaizik, Cassandra, Devenney, Emma, Connaughton, Emily, Langdon, Robyn, Mioshi, Eneida, Kwok, John B., Dobson‐Stone, Carol, Halliday, Glenda M., Piguet, Olivier, Hodges, John R., Landin‐Romero, Ramon“…METHODS: Four‐hundred and eighty‐seven people with dementia were recruited: 102 Alzheimer's disease, 136 behavioural‐variant frontotemporal dementia, 154 primary progressive aphasia, 29 motor neurone disease, 46 corticobasal syndrome, 20 progressive supranuclear palsy. …”
Publicado 2022
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405por Preston, David C.Tabla de Contenidos: “…Overview of nerve conduction studies and electromyography -- Approach to nerve conduction studies and electromyography -- Anatomy and neurophysiology -- Fundamentals of nerve conduction studies -- Basic nerve conduction studies -- Late responses -- Blink reflex -- Repetitive nerve stimulation -- Sources of error: anomalies, artifacts, technical factors and statistics -- Anomalous innervations -- Artifacts and technical factors -- Basic statistics for electrodiagnostic studies -- Detailed nerve conduction studies -- Routine upper extremity, facial and phrenic nerve conduction techniques -- Routine lower extremity nerve conduction studies -- Fundamentals of electromyography -- Basic overview of electromyography -- Anatomy for needle electromyography -- Basic electromyography: analysis of spontaneous activity -- Basic electromyography: analysis of motor unit action potentials -- Clinical-electrophysiologic correlations -- Clinical-electrophysiologic correlations: overview and common patterns -- Common mononeuropathies -- Median neuropathy at the wrist -- Proximal median neuropathy -- Ulnar neuropathy at the elbow -- Ulnar neuropathy at the wrist -- Radial neuropathy -- Peroneal neuropathy -- Femoral neuropathy -- Tarsal tunnel syndrome -- Facial and trigeminal neuropathy -- Polyneuropathy -- Motor neuron disease -- Amyotrophic lateral sclerosis and its variants -- Atypical motor neuron diseases -- Radiculopathy, plexopathies and proximal neuropathies -- Radiculopathy -- Brachial plexopathy -- Proximal neuropathies of the shoulder and arm -- Lumbosacral plexopathy -- Sciatic neuropathy -- Disorders of neuromuscular junction and muscle -- Neuromuscular junction disorders -- Myopathy -- Myotonic muscle disorders and periodic paralysis syndromes -- Electromyography in special clinical settings -- Approach to electrodiagnostic studies in the intensive care unit -- Approach to pediatric electromyography -- Electronics and instrumentation -- Basis of electricity and electronics for electrodiagnostic studies -- Electrical safety and iatrogenic complications of electrodiagnostic studies.…”
Publicado 2013
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406Publicado 2013“…This finding emphasises the importance of pursuing adequately powered trials with clear endpoints when testing new treatments. FUNDING: The Motor Neurone Disease Association of Great Britain and Northern Ireland.…”
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407“…Hospital cost reductions were observed for decedents with organ failures, chronic obstructive pulmonary disease, Alzheimer’s disease, Parkinson’s disease and cancer but not for motor neurone disease. Cost reductions associated with community-based specialist palliative care were evident 4 months before death for decedents with cancer and by one to 2 months before death for decedents dying from other conditions. …”
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408por Truong, Phan H., Crouch, Peter J., Hilton, James B. W., McLean, Catriona A., Cappai, Roberto, Ciccotosto, Giuseppe D.“…Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle paralysis and death. …”
Publicado 2021
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409por Bausewein, Claudia, Jolley, Caroline, Reilly, Charles, Lobo, Paula, Kelly, Jane, Bellas, Helene, Madan, Preety, Panell, Caty, Brink, Elmien, De Biase, Chiara, Gao, Wei, Murphy, Caroline, McCrone, Paul, Moxham, John, Higginson, Irene J“…Patients are included if suffering from breathlessness on exertion or at rest due to advanced disease such as cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), interstitial lung disease (ILD) or motor neurone disease (MND) that is refractory to maximal optimised medical management. …”
Publicado 2012
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410Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling studypor Al-Chalabi, Ammar, Calvo, Andrea, Chio, Adriano, Colville, Shuna, Ellis, Cathy M, Hardiman, Orla, Heverin, Mark, Howard, Robin S, Huisman, Mark H B, Keren, Noa, Leigh, P Nigel, Mazzini, Letizia, Mora, Gabriele, Orrell, Richard W, Rooney, James, Scott, Kirsten M, Scotton, William J, Seelen, Meinie, Shaw, Christopher E, Sidle, Katie S, Swingler, Robert, Tsuda, Miho, Veldink, Jan H, Visser, Anne E, van den Berg, Leonard H, Pearce, Neil“…FUNDING: UK Medical Research Council; UK Economic and Social Research Council; Ireland Health Research Board; The Netherlands Organisation for Health Research and Development (ZonMw); the Ministry of Health and Ministry of Education, University, and Research in Italy; the Motor Neurone Disease Association of England, Wales, and Northern Ireland; and the European Commission (Seventh Framework Programme).…”
Publicado 2014
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411por Bocchetta, Martina, Gordon, Elizabeth, Cardoso, M. Jorge, Modat, Marc, Ourselin, Sebastien, Warren, Jason D., Rohrer, Jonathan D.“…We assessed subgroups stratified by clinical diagnosis (141 behavioural variant FTD (bvFTD), 76 semantic dementia (SD), 103 progressive nonfluent aphasia (PNFA), 7 with associated motor neurone disease (FTD-MND) and 14 primary progressive aphasia not otherwise specified (PPA-NOS), genetic diagnosis (24 with MAPT, 24 with C9orf72, and 15 with GRN mutations), and pathological diagnosis (40 tauopathy, 61 TDP-43opathy, 3 FUSopathy). …”
Publicado 2018
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412por Neville, Daniel M, Rupani, Hitasha, Kalra, Paul R, Adeniji, Kayode, Quint, Matthew, De Vos, Ruth, Begum, Selina, Mottershaw, Mark, Fogg, Carole, Jones, Thomas L, Lanning, Eleanor, Bassett, Paul, Chauhan, Anoop J“…Participants with a confirmed diagnosis of asthma, breathing pattern disorders, chronic heart failure, motor neurone disease, pneumonia, as well as volunteers with no history of lung disease will be asked to provide twice daily, 75-second TBCO(2) collection via the N-Tidal C device for 6 months duration. …”
Publicado 2018
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413“…Two participants were family carers and supported people living with epilepsy and motor neurone disease. Findings were analysed using thematic analysis. …”
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414por Byrne, Susan, Elamin, Marwa, Bede, Peter, Shatunov, Aleksey, Walsh, Cathal, Corr, Bernie, Heverin, Mark, Jordan, Norah, Kenna, Kevin, Lynch, Catherine, McLaughlin, Russell L, Iyer, Parameswaran Mahadeva, O'Brien, Caoimhe, Phukan, Julie, Wynne, Brona, Bokde, Arun L, Bradley, Daniel G, Pender, Niall, Al-Chalabi, Ammar, Hardiman, Orla“…FUNDING: Health Seventh Framework Programme, Health Research Board, Research Motor Neuron, Irish Motor Neuron Disease Association, The Motor Neurone Disease Association of Great Britain and Northern Ireland, ALS Association.…”
Publicado 2012
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415por Shatunov, Aleksey, Mok, Kin, Newhouse, Stephen, Weale, Michael E, Smith, Bradley, Vance, Caroline, Johnson, Lauren, Veldink, Jan H, van Es, Michael A, van den Berg, Leonard H, Robberecht, Wim, Van Damme, Philip, Hardiman, Orla, Farmer, Anne E, Lewis, Cathryn M, Butler, Amy W, Abel, Olubunmi, Andersen, Peter M, Fogh, Isabella, Silani, Vincenzo, Chiò, Adriano, Traynor, Bryan J, Melki, Judith, Meininger, Vincent, Landers, John E, McGuffin, Peter, Glass, Jonathan D, Pall, Hardev, Leigh, P Nigel, Hardy, John, Brown, Robert H, Powell, John F, Orrell, Richard W, Morrison, Karen E, Shaw, Pamela J, Shaw, Christopher E, Al-Chalabi, Ammar“…FUNDING: ALS Therapy Alliance, the Angel Fund, the Medical Research Council, the Motor Neurone Disease Association of Great Britain and Northern Ireland, the Wellcome Trust, and the National Institute for Health Research Dementias and Neurodegenerative Diseases Research Network (DeNDRoN).…”
Publicado 2010
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416“…OBJECTIVE: To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection. …”
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417por Werner, Jana, Jelcic, Ilijas, Schwarz, Esther Irene, Probst-Müller, Elisabeth, Nilsson, Jakob, Schwizer, Bernhard, Bloch, Konrad Ernst, Lutterotti, Andreas, Jung, Hans-Heinrich, Schreiner, Bettina“…All patients showed clinical or electrophysiologic signs of motor neuron disease without fulfilling the diagnostic criteria for amyotrophic lateral sclerosis. …”
Publicado 2021
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418por ROWLAND, L.P.“…Two other neuromuscular syndromes in people with HIV antibodies are nemaline myopathy and bibrachial amyotrophic diplegia, a form of motor neuron disease. The associations between these diseases and the possibility that HIV infection could be a risk factor for either amyotrophic lateral sclerosis (ALS) itself or other motor neuron diseases are investigated.…”
Publicado 2011
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419“…Tandem mutations in the AAAS gene may be involved in co-morbid motor neuron disease and aberrant electrophysiological findings.…”
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420“…The study findings are preliminary and should be validated through a prospective national quality registry for motor neuron diseases.…”
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