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Mostrando 521 - 540 Resultados de 1,213 Para Buscar '"motor neurone disease"', tiempo de consulta: 1.34s Limitar resultados
  1. 521
    “…The further discovery that brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF) and glial cell line-derived neurotrophic factor (GDNF) had potent survival-promoting activity on motor neurons led to the proposal for their use in motor neuron diseases such as amyotrophic lateral sclerosis (ALS). …”
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    Neurotrophic factors in the physiology of motor neurons and their role in the pathobiology and therapeutic approach to amyotrophic lateral sclerosis
  2. 522
    “…Motor neuron diseases (MNDs) are a rather heterogeneous group of diseases, with either sporadic or genetic origin or both, all characterized by the progressive degeneration of motor neurons. …”
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    Altered Gene Expression, Mitochondrial Damage and Oxidative Stress: Converging Routes in Motor Neuron Degeneration
  3. 523
    “…Spinal bulbar muscular atrophy (SBMA) is a motor neuron disease caused by a CAG trinucleotide expansion in the androgen receptor (AR) gene. …”
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    Sequencing analysis of the spinal bulbar muscular atrophy CAG expansion reveals absence of repeat interruptions()
  4. 524
    “…Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease. It is the first genetic cause of infant mortality. …”
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    Molecular, genetic and stem cell-mediated therapeutic strategies for spinal muscular atrophy (SMA)
  5. 525
    “…Clinically MMN is a pure motor neuropathy, which as such can mimic motor neuron disease. GM1-specific IgM antibodies are present in the serum of approximately half of all MMN patients, and are thought to play a key role in the immune pathophysiology. …”
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    MMN: From Immunological Cross-Talk to Conduction Block
  6. 526
    “…Affected individuals have cerebellar and corpus callosum hypoplasia, abnormal myelination of the central nervous system or spinal motor neuron disease. Experimental downregulation of EXOSC8 in human oligodendroglia cells and in zebrafish induce a specific increase in ARE mRNAs encoding myelin proteins, showing that the imbalanced supply of myelin proteins causes the disruption of myelin, and explaining the clinical presentation. …”
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    EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia
  7. 527
    por Ferguson, Ross, Subramanian, Vasanta
    Publicado 2016
    “…We also show the application of this system to study proteins implicated in motor neuron disease.…”
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    PA6 Stromal Cell Co-Culture Enhances SH-SY5Y and VSC4.1 Neuroblastoma Differentiation to Mature Phenotypes
  8. 528
    “…Changes to this coupling is associated with a number of metabolic disorders and neurodegenerative diseases including Alzheimer’s, Parkinson’s and motor neuron disease. The distance between the two membranes at regions of close apposition is below the resolution of conventional light microscopy, which makes analysis of these interactions challenging. …”
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    A Bi-fluorescence complementation system to detect associations between the Endoplasmic reticulum and mitochondria
  9. 529
    “…Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. …”
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    Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
  10. 530
    “…RATIONALE: Monomelic amyotrophy (MMA) is a benign motor neuron disease with bilateral muscular atrophy in asymmetry and abnormal in the electromyography (EMG). …”
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    Benign monomelic amyotrophy with lower limb involvement in an adult: A case report
  11. 531
    “…Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults and primarily targets upper and lower motor neurons. …”
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    Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis
  12. 532
    “…Amyotrophic lateral sclerosis (ALS) is one of the most common motor neuron diseases (MND), which presents as muscle weakness, atrophy, spasticity, and, in extreme cases, may result in death due to respiratory failure. …”
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    Young-onset Amyotrophic Lateral Sclerosis with Rare Skin Manifestation: Case Report and Literature Review
  13. 533
    por Kesserwani, Hassan
    Publicado 2021
    “…However, peripheral causes such as motor neuron disease, mononeuritis multiplex (vasculitis), bilateral brachial plexopathy, and critical illness myopathy have been sporadically reported and can stochastically inflict the motor nerves or muscles of the upper extremities. …”
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    "Person-in-the-Barrel" Syndrome: A Case Report of Bilateral Arm Paresis Due to Vasculitis With a Review of Pathological Mechanisms
  14. 534
    “…With cost less than 30$, patients with motor neuron diseases such as Amyotrophic Lateral Sclerosis (ALS) can communicate easily with the others, express their needs and simply live their life normally.…”
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    Morse glasses: an IoT communication system based on Morse code for users with speech impairments
  15. 535
    “…Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease that, in the most severe cases and when left untreated, leads to death within the first two years of life. …”
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    Spinal muscular atrophy: From approved therapies to future therapeutic targets for personalized medicine
  16. 536
    “…Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor neuron disease. While promising causal therapies are available, meaningful prognostic biomarkers for therapeutic monitoring are missing. …”
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    Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
  17. 537
    “…Through this review, we describe how early age of onset, family history of early dementia, parkinsonism, dystonia, or motor neuron disease among other clinical features, as well as some neuroimaging signatures, may be the important clues to suspect PSP syndrome of monogenic origin. …”
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    Genotype–Phenotype Correlation in Progressive Supranuclear Palsy Syndromes: Clinical and Radiological Similarities and Specificities
  18. 538
    “…Spinocerebellar ataxias (SCAs) comprise a group of complex and heterogeneous hereditary neurodegenerative disorders characterized by cerebellar ataxia, with ophthalmoplegia, pyramidal and extrapyramidal features, peripheral neuropathy, motor neuron disease, pigmentary retinopathy, epilepsy, and dementia in varying proportions. …”
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    Cognition in Trinucleotide Repeat Spinocerebellar Ataxias: A Review
  19. 539
    “…Misfolded forms of superoxide dismutase 1 (SOD1) with mutations associated with familial amyotrophic lateral sclerosis (fALS) exhibit prion characteristics, including the ability to act as seeds to accelerate motor neuron disease in mouse models. A key feature of infectious prion seeding is that the efficiency of transmission is governed by the primary sequence of prion protein (PrP). …”
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    Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence
  20. 540
    “…INTERVENTION AND OUTCOME: After 1 month of treatment with tui na and traditional western medicine, the patient’s lung function and quality of life improved and he was discharged from the hospital. DIAGNOSES: Motor neuron disease. Amyotrophic lateral sclerosis. LESSONS: The physiological function of ALS patients can be improved through the intervention of tui na.…”
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    Combined Tui na and Western medicine treatment improves pulmonary function and quality of life in patients with amyotrophic lateral sclerosis: A case report
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