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1981“…We argue that what appears to be an interdisciplinary model transfer between different domains turns out, from a broader perspective, to be the application of transdisciplinary model templates across a multitude of domains. We also point out a further feature of template-based modeling that so far has not been discussed: template entanglement. …”
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1982por Oronsky, Bryan, Caroen, Scott, Brinkhaus, Franck, Reid, Tony, Stirn, Meaghan, Kumar, Raj“…Despite an ever-increasing need for newer, safer, more effective, and more affordable therapies to treat a multitude of diseases and conditions, drug development takes too long, costs too much, and is too uncertain to be undertaken without the conferment of exclusionary rights or entry barriers to motivate and sustain investment in it. …”
Publicado 2023
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1983por Martínez-García, Mireya, Rodríguez-Hernández, Adriana-Patricia, Gutiérrez-Esparza, Guadalupe O., Castrejón-Pérez, Roberto Carlos, Hernández-Lemus, Enrique, Borges-Yáñez, Socorro Aída“…Few studies have focused on the multitude of factors related to social development as indicators of living conditions and periodontal health status. …”
Publicado 2023
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1984por Jiang, Hao, Zhang, Mutang, Lin, Xiaoling, Zheng, Xiaoqing, Qi, Heming, Chen, Junping, Zeng, Xiaofang, Bai, Weidong, Xiao, Gengsheng“…Naringin (NG), a natural flavanone glycoside, possesses a multitude of pharmacological properties, encompassing anti-inflammatory, sedative, antioxidant, anticancer, anti-osteoporosis, and lipid-lowering functions, and serves as a facilitator for the absorption of other drugs. …”
Publicado 2023
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1985por Biswas, Soma, Sarojini, Suma, Jayaram, Saranya, Philip, Indhu, Umesh, Mridul, Mascarenhas, Roseanne, Pappuswamy, Manikantan, Balasubramanian, Balamuralikrishnan, Arokiyaraj, Selvaraj“…AMPs are small oligopeptides acting as integral elements of the innate immune system and are of tremendous potential in the medical field owing to their antimicrobial and immunomodulatory activities. They offer a multitude of immunomodulatory properties such as immune cell differentiation, inflammatory responses, cytokine production, and chemoattraction. …”
Publicado 2023
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1986por Davidović, David, Kukulka, Mercedes, Sarmento, Maria J., Mikhalyov, Ilya, Gretskaya, Natalia, Chmelová, Barbora, Ricardo, Joana C., Hof, Martin, Cwiklik, Lukasz, Šachl, Radek“…[Image: see text] Gangliosides are important glycosphingolipids involved in a multitude of physiological functions. From a physicochemical standpoint, this is related to their ability to self-organize into nanoscopic domains, even at molar concentrations of one per 1000 lipid molecules. …”
Publicado 2023
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1987“…Ran-GTP produced around chromosomes controls the activity of a multitude of spindle assembly factors by releasing them from inhibitory interaction with importins. …”
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1988por Derbois, Céline, Palomares, Marie-Ange, Deleuze, Jean-François, Cabannes, Eric, Bonnet, Eric“…In biomedical research, PBMCs are commonly used to study global immune response to disease outbreak and progression, pathogen infections, for vaccine development and a multitude of other clinical applications. Over the past few years, the revolution in single-cell RNA sequencing (scRNA-seq) has enabled an unbiased quantification of gene expression in thousands of individual cells, which provides a more efficient tool to decipher the immune system in human diseases. …”
Publicado 2023
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1989“…Extracellular vesicles (EVs) are nanoscopic, heterogenous, lipid-rich particles that carry a multitude of cargo biomolecules including proteins, nucleic acids, and metabolites. …”
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1990por Townsend, Jeremy R., Kirby, Trevor O., Marshall, Tess M., Church, David D., Jajtner, Adam R., Esposito, Ralph“…Many countries struggle with malnutrition or caloric deficits, while others encounter difficulties with caloric overconsumption and micronutrient deficiencies. A multitude of factors contribute to this global problem. …”
Publicado 2023
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1991“…In mammalian testes, while a great multitude of lncRNA species are identified, only a minority of them have been shown to be useful, and even fewer have been demonstrated as true requirements for male fertility using knockout models to date. …”
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1992“…Among them, the research status of TSV hole etching, deep hole electroplating filling and chemical mechanical planarization (CMP) in TSV preparation process are introduced in detail. There are a multitude of inevitable defects in the process of TSV processing; thus, the stress problems and electrical characteristics that affect the reliability of TSV are summarized in this review. …”
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1993por Zhu, Wei, Wang, Wenguo, Wang, Dayong, Wang, Gang, Cui, Aiming, Xi, Yongzai, Li, Fei, Zhang, Baowei, Zhang, Gege“…This paper delves into the electrical characteristics of water-bearing layers within mudflats, and ascertains details pertaining to the subterranean structure and the spatial distribution of fresh and saline water resources, through the holistic interpretation of a multitude of profiles.…”
Publicado 2023
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1994“…The primary role of semen processing and preservation is to maintain a high proportion of structurally and functionally competent and mature spermatozoa, that may be used for the purposes of artificial reproduction when needed, whilst minimizing any potential causes of sperm deterioration during ex vivo semen handling. Out of a multitude of variables determining the success of sperm preservation, bacterial contamination has been acknowledged with an increased interest because of its often unpredictable and complex effects on semen quality. …”
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1995“…In the intestine, a multitude of functions have been attributed to HNF4 and its accessory transcription factors, including but not limited to, intestinal maturation, differentiation, regeneration, and stem cell renewal. …”
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1996“…Despite the well-established status of stimuli-responsive polymeric systems in other fields, their implementation in dentistry is still in its nascent stages, presenting a multitude of promising opportunities for advancement. …”
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1997por Hwang, Mihwa, Jun, Dong Wha, Song, Bo Ram, Shim, Hanna, Lee, Chang-Hun, Kim, Sunshin“…Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). …”
Publicado 2023
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1998por Hibberd, Timothy J., Ramsay, Stewart, Spencer-Merris, Phaedra, Dinning, Phil G., Zagorodnyuk, Vladimir P., Spencer, Nick J.“…Peripheral clocks are subject to entrainment by a multitude of factors, many of which are directly or indirectly controlled by the light-entrainable clock located in the suprachiasmatic nucleus of the hypothalamus. …”
Publicado 2023
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1999“…In recent years, with the increases in microorganisms that express a multitude of antimicrobial resistance (AMR) mechanisms, the threat of antimicrobial resistance in the global population has reached critical levels. …”
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2000por Arjmand, Shokouh, Bender, Dirk, Jakobsen, Steen, Wegener, Gregers, Landau, Anne M.“…Estrogen receptors (ERs) play a multitude of roles in brain function and are implicated in various brain disorders. …”
Publicado 2023
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