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  1. 6301
    “…It enables miRNA researchers to computationally address complex questions involving the multitude of miRNA data resources. Furthermore, miRMaid constitutes a basic framework for further programming in which microRNA-interested bioinformaticians can readily develop their own tools and data sources.…”
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    miRMaid: a unified programming interface for microRNA data resources
  2. 6302
    “…BACKGROUND: Regime shifts are abrupt changes encompassing a multitude of physical properties and ecosystem variables, which lead to new regime conditions. …”
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    The Mediterranean Sea Regime Shift at the End of the 1980s, and Intriguing Parallelisms with Other European Basins
  3. 6303
    “…CONCLUSIONS/SIGNIFICANCE: We conclude that in prostate cancer cells the proliferative signals are likely to be transmitted from multiple growth factor receptors by a multitude of signaling pathways converging on several key regulators of cell proliferation such as c-Myc, Cyclin D and CREB1. …”
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    “Topological Significance” Analysis of Gene Expression and Proteomic Profiles from Prostate Cancer Cells Reveals Key Mechanisms of Androgen Response
  4. 6304
    “…BACKGROUND: Many women are working outside of the home, occupying a multitude of jobs with varying degrees of responsibilities and levels of psychological stress. …”
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    Mother's occupation and sex ratio at birth
  5. 6305
    “…OBJECTIVES: Commercially produced sterile green bottle fly Lucilia sericata maggots are successfully employed by practitioners worldwide to clean a multitude of chronic necrotic wounds and reduce wound bacterial burdens during maggot debridement therapy (MDT). …”
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    A novel approach to the antimicrobial activity of maggot debridement therapy
  6. 6306
    “…BACKGROUND: Developing a patient safety culture was one of the recommendations made by the Institute of Medicine to assist hospitals in improving patient safety. In recent years, a multitude of evidence, mostly originating from developed countries, has been published on patient safety culture. …”
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    Predictors and outcomes of patient safety culture in hospitals
  7. 6307
    “…Polyunsaturated fatty acids (PUFA) have a multitude of health effects. Their incorporation into membrane phospholipids (PL) is generally believed to depend directly on dietary influx. …”
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    Diet-Independent Remodeling of Cellular Membranes Precedes Seasonally Changing Body Temperature in a Hibernator
  8. 6308
    “…Genetic studies have implicated a multitude of proteins in the process, including helicases, nucleases, and topoisomerases(2–4). …”
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    DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
  9. 6309
    por Bashir, Ali, Bansal, Vikas, Bafna, Vineet
    Publicado 2010
    “…These technologies are also being used in novel ways for mRNA expression profiling, genome-wide discovery of transcription-factor binding sites, small RNA discovery, etc. The multitude of sequencing platforms, each with their unique characteristics, pose a number of design challenges, regarding the technology to be used and the depth of sequencing required for a particular sequencing application. …”
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    Designing deep sequencing experiments: detecting structural variation and estimating transcript abundance
  10. 6310
    “…BACKGROUND: siRNA technology is a promising tool for gene therapy of vascular disease. Due to the multitude of reagents and cell types, RNAi experiment optimization can be time-consuming. …”
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    High throughput RNAi assay optimization using adherent cell cytometry
  11. 6311
    “…Epigenetic regulation consists of a multitude of different modifications that determine active and inactive states of chromatin. …”
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    Podbat: A Novel Genomic Tool Reveals Swr1-Independent H2A.Z Incorporation at Gene Coding Sequences through Epigenetic Meta-Analysis
  12. 6312
    “…BACKGROUND: Cells adapt to various chronic toxic exposures in a multitude of ways to minimize further damage and maximize their growth potential. …”
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    Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics
  13. 6313
    “…The complex structure of dental biofilms, allowing for a multitude of different ecological environments in close proximity, remains largely unexplored. …”
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    pH Landscapes in a Novel Five-Species Model of Early Dental Biofilm
  14. 6314
    “…Whole genome expression profiling of TM and peritoneal macrophages (PM) infected with uropathogenic E. coli (UPEC) revealed major differences in regulated genes. However, a multitude of genes implicated in calcium signaling pathways was a common feature which indicated a role of calcium-dependent nuclear factor of activated T cells (NFAT) signaling. …”
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    Uropathogenic E. coli Induce Different Immune Response in Testicular and Peritoneal Macrophages: Implications for Testicular Immune Privilege
  15. 6315
    “…BACKGROUND: There are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and diseases. …”
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    Connecting the Dots between PubMed Abstracts
  16. 6316
    “…These different states of microglia/macrophages reflect the complexity of these cells and their ability to differentiate towards a multitude of phenotypes depending on the surrounding micro-environmental signals that can change over time. …”
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    Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
  17. 6317
    “…Influenza-specific memory CD8(+) T-cell response maintained a highly functional profile in terms of multitude of effector molecule expression (CD107a, IFN-γ, TNF-α, MIP-1β and IL-2) and showed high avidity even in the setting of SIV infection. …”
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    Comparison of Influenza and SIV Specific CD8 T Cell Responses in Macaques
  18. 6318
    “…The up- or down-regulated proteins were functionally analyzed using Ingenuity Pathways Analysis (IPA) to interpret the interaction network and predominant canonical pathways involved in these differentially expressed proteins. CONCLUSIONS: A multitude of differentially expressed proteins was found to be associated with HSF4b and a T→C transition at nucleotide 348 in HSF4b. …”
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    Proteomic analysis of SRA01/04 transfected with wild-type and mutant HSF4b identified from a Chinese congenital cataract family
  19. 6319
    por Rho, Young-Ah, Prescott, Steven A.
    Publicado 2012
    “…“Bias” can arise from a multitude of molecular changes occurring alone or in combination; in the latter case, changes can add or offset one another. …”
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    Identification of Molecular Pathologies Sufficient to Cause Neuropathic Excitability in Primary Somatosensory Afferents Using Dynamical Systems Theory
  20. 6320
    “…Lysophosphatidic acid (LPA), a naturally occurring bioactive phospholipid, mediates a multitude of (patho)physiological events including activation of mitogen-activated protein kinases (MAPKs). …”
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    LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis
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