“…Here, we review the history of GOLPH2’s discovery and the multitude of studies by many groups around the world aimed at understanding its molecular, cellular, physiological, and pathogenic activities in various settings.…”
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“…Because of the low incidence of these tumors, there are currently no clinical guidelines outlining their management and a multitude of therapeutic strategies have been employed with varying success. …”
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“…Although the effect of individual cytokines on osteoclast formation is well characterized, the major challenge is to fit a multitude of redundant pathways and cytokines into a systemic model of postmenopausal osteoporosis. …”
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“…Unfortunately, the complex nature of this organ’s development also makes it a prime target for mutation-induced malformation, as evidenced by the multitude of prevalent congenital heart disorders identified that afflict up to 1% of the population.…”
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“…While it is widely accepted that TSH outside of the normal range is consistent with thyroid dysfunction, a vast multitude of additional factors must be considered before an accurate clinical diagnosis can be made. …”
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“…The epigenetic apparatus is essential for controlling normal development and homeostasis, and also provides a means for the organism to integrate and react upon environmental cues. A multitude of functional studies as well as systematic genome-wide mapping of epigenetic marks and chromatin modifiers reveal the importance of epigenomic mechanisms in human pathologies, including inflammatory conditions and musculoskeletal disease such as rheumatoid arthritis. …”
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“…The multitude of applications offered by CMR make it an increasing popular modality to study the heart and the surrounding vessels. …”
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“…They function as molecular switches, aided by a multitude of regulatory and effector proteins that link them into functional networks. …”
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“…Healthcare industry is flooded with multitude of drugs, and the list is increasing day by day. …”
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“…In this review, we outline the actions of CO in the cardiovascular system and highlight this gas as a potential therapeutic target in treating a multitude of cardiovascular disorders.…”
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“…In various areas of the bio-medical, pharmacological and psychological research a multitude of behavioural tests have been used to investigate the effects of environmental, genetic and epi-genetic factors as well as pharmacological substances or diseased states on behaviour and thus on the physiological and psycho-social status of experimental subjects. …”
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“…This is because of high prevalence of undiagnosed gluten related disorders presenting with a multitude of symptoms and complications inside and outside small bowel. …”
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“…The relatively large size of the gecko and its ability to climb a multitude of structures with ease has often been cited as the inspiration upon which the field of dry adhesives is based. …”
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“…Potassium channels are pore-forming transmembrane proteins that regulate a multitude of biological processes by controlling potassium flow across cell membranes. …”
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“…While the represented space is confined, it encompasses nearly all the ion channel PLH bundles for which the structures are currently known. For a multitude of channels, gating models suggested by paths within the confined accessible space are in qualitative agreement with those established in previous structural and computational studies.…”
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“…A multitude of metagenomic studies has brought to light an enormous richness of human gut microbiota compositions. …”
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“…Proteinases are involved in a multitude of important physiological processes, such as protein metabolism. …”
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“…Interpretation of the multitude of variants obtained from next generation sequencing (NGS) is labor intensive and complex. …”
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“…Brucellosis is endemic in livestock and humans in Uganda and its transmission involves a multitude of risk factors like consumption of milk from infected cattle. …”
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“…With the discovery of beta-catenin pathway and sclerostin molecule, these cells are now being recognized to perform a multitude of physiological functions which are important to bone function and turnover. …”
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