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841“…The JAK/STAT signaling pathway plays a multitude of important biological functions in both normal and malignant cells. …”
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842por Khan, Sabbir, Mittal, Sandeep, McGee, Kain, Alfaro-Munoz, Kristin D., Majd, Nazanin, Balasubramaniyan, Veerakumar, de Groot, John F.“…The role of tumor-associated neutrophils and myeloid-derived suppressor cells in cancer biology remains elusive, as these cells can exert a multitude of pro-tumor and antitumor effects. In this review, we provide the current understanding and novel insights on the role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance, as well as the mechanisms of pleiotropic behaviors in these cells during disease progression, with an emphasis on possible strategies to reprogram these cells towards their antitumor actions.…”
Publicado 2020
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843“…We use here a computational model of a cortex-like recurrent neural network adapted by a multitude of plasticity mechanisms. We first demonstrate the learning of a sequence. …”
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844“…The year 2019 brought about a multitude of innovations in clinical infectious diseases. …”
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845por Köhn, Maja“…Imbalances in phosphorylation levels are involved in a multitude of diseases. Phosphatases are often thought of as the black sheep, the strangers, of phosphorylation-mediated signal transduction, particularly when it comes to drug discovery and development. …”
Publicado 2020
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846“…SUMMARY: Skull base surgeons must consider a multitude of perioperative factors. While many components of perioperative management are extrapolated from related fields such as endoscopic sinus surgery or open cranial base surgery, additional high-quality studies are needed to delineate best practices specific to endoscopic skull base surgery.…”
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847“…Therapeutic approaches towards a functional cure or eradication of HIV have gained renewed momentum upon encouraging data emerging from studies in SIV monkey models and recent results from human clinical studies. However, a multitude of questions remain to be addressed, including how to deal with the latent viral reservoir, how to boost the host immune response to the virus and what the hurdles are to reach relevant viral compartments in the body. …”
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848por Sipior, Janice C.“…Since the outbreak of the pandemic, there has been an upsurge in the exploration and use of AI, and other data analytic tools, in a multitude of areas. This paper addresses some of the many considerations for managing the development and deployment of AI applications, including planning; unpredictable, unexpected, or biased results; repurposing; the importance of data; and diversity in AI team membership. …”
Publicado 2020
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849“…The disease burden of dengue has been steadily rising over the last half-century due to a multitude of factors, including global trade and travel, urbanization, population growth, and climate variability and change, that facilitate conductive conditions for the proliferation of dengue vectors and viruses. …”
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850por Kuehlmann, Britta, Bonham, Clark A., Zucal, Isabel, Prantl, Lukas, Gurtner, Geoffrey C.“…These cells produce a multitude of molecules and initiate multiple signaling pathways that are associated with skin disorders and abnormal wound healing, including hypertrophic scars, keloids, and chronic wounds. …”
Publicado 2020
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851“…This observation likely explains the multitude of symptoms that have been described from human patients. …”
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852“…Essential healthcare services, including multi-disciplinary team (MDT) meetings that make medical decisions, are expected to continue uninterrupted in this time of social distancing. There are a multitude of virtual platforms available to enable remote MDT meetings, and the pandemic has accelerated their arrival into daily healthcare practice. …”
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853“…However, randomized controlled trials are the need of the hour to conclusively determine its clinical efficacy in such infections. A review of the multitude of mechanisms of action, updated screening and monitoring guidelines, drug interactions, side effects, and its use in special populations is described.…”
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854“…Due to the direct contact with the environment the lungs are exposed to a multitude of viruses. This article describes four viral pathogens, which can lead to pulmonary manifestations but are little known because they are rare in Germany. …”
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855por Clark, Elisia, Johnson, Joseph, Dong, Yi Na, Mercado-Ayon, Elizabeth, Warren, Nathan, Zhai, Mattieu, McMillan, Emily, Salovin, Amy, Lin, Hong, Lynch, David R.“…Consequently, present therapies focus not only on free radical damage, but also on control of metabolic abnormalities and correction of mitochondrial biogenesis. Understanding the multitude of abnormalities in FRDA thus offers possibilities for treatment of this disorder.…”
Publicado 2018
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856“…This is guided by a multitude of noncoding RNAs of different sizes and functions, the extent of which is only recently becoming clear. …”
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857por Xing, Qiao Rui, Cipta, Nadia Omega, Hamashima, Kiyofumi, Liou, Yih-Cherng, Koh, Cheng Gee, Loh, Yuin-Han“…To deconstruct the heterogeneity, a multitude of single-cell toolkits measuring various cellular contents, including genome, transcriptome, epigenome, and proteome, have been developed. …”
Publicado 2020
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858“…These germline-encoded receptors trigger a multitude of innate responses including phagocytosis, fungal killing, and antigen presentation which can also shape the development of adaptive immunity. …”
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859“…The choice of surgical treatment depends on a multitude of factors like chronicity of infection, host factors, and institutional or surgeon experience. …”
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860“…Exposure of genomic DNA to UV light leads to the formation of multitude of types of damage (depending on wavelength and exposure time) that are removed by effectively working repair pathways. …”
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