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961“…This review summarizes the recent progresses in our understanding of how budding yeast cells orchestrate the multitude of molecular mechanisms that control AMR driven cytokinesis in a spatio-temporal manner to achieve an error free cell division.…”
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962“…Multi-organ platforms have an enormous potential to lead to a paradigm shift in a multitude of research domains including drug development, toxicological screening, personalized medicine as well as disease modeling. …”
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963por Suh, Yiji, Gandhi, Jason, Joshi, Gunjan, Lee, Min Yea, Weissbart, Steven J., Smith, Noel L., Joshi, Gargi, Khan, Sardar Ali“…Symptoms can occur due to a multitude of reasons, but are usually benign and self-limiting, requiring no additional treatment or evaluation. …”
Publicado 2017
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964“…The regulation of oxygen (O(2)) levels is crucial in embryogenesis and adult life, as O(2) controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for tissue physiology as they are integral to adequate metabolism regulation and cell fate. …”
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965por Riedemann, Therese“…Each class is, in turn, composed of a multitude of subclasses, resulting in a growing number of interneuron classes and subclasses. …”
Publicado 2019
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966“…The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis. …”
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967“…The coexistence of a multitude of mechanisms that may act simultaneously or consecutively and differ among various cell types poses particular challenges to researchers. …”
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968“…Understanding the intricate interaction pattern of nucleic acids with other molecules is essential to gain further insight in biological processes and disease mechanisms. To this end, a multitude of hybridization-based assays have been designed that rely on the non-covalent recognition between complementary nucleic acid sequences. …”
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969por Pardridge, William M.“…Drugs that do not cross the BBB can be re-engineered for transport on endogenous BBB carrier-mediated transport and receptor-mediated transport systems, which were identified during the 1970s–1980s. By the 1990s, a multitude of brain drug delivery technologies emerged, including trans-cranial delivery, CSF delivery, BBB disruption, lipid carriers, prodrugs, stem cells, exosomes, nanoparticles, gene therapy, and biologics. …”
Publicado 2022
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970“…Radiotherapy (RT) induces a multitude of alterations within the tumor ecosystem, ultimately modifying the degree of tumor immunogenicity at GBM relapse. …”
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971por Soler-Alcaraz, Sofía, Guerrero-Sánchez, Yolanda, Pérez-Sayáns, Mario, Bernabeu-Mira, Juan Carlos, Peñarrocha-Oltra, David, Camacho-Alonso, Fabio“…Osseointegration is a process that depends on a multitude of factors, including the type of drilling, whether biological or conventional. …”
Publicado 2023
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972“…In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. …”
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973por Thomson, Brodie. J., Hanna, Summer, Schwarzenberg, Adrian, Kiani, Pirouz, Bizzotto, Dan, Kennepohl, Pierre, Davies, Ashley, Roggen, Markus, Sammis, Glenn M.“…Studies supported by calculations indicate that this intermediate rapidly reacts with oxygen to form a multitude of cannabinoid products. The purple colour observed in light-aged CBD-containing solutions is largely due to the anions of these by-products and is not significantly due to the HU-331 anion. …”
Publicado 2023
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974“…Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits, vegetables, and leaves. They have a multitude of medicinal applications due to their anti-inflammatory, antioxidative, antiviral, and anticarcinogenic properties. …”
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975“…OPN is involved in a multitude of biological processes, such as activation and regulation of the immune system; biomineralization; tissue-transformative processes, including growth and development of the gut and brain; interaction with bacteria; and many more. …”
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976“…Proliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan communication, and tumor progression. …”
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977“…Establishing better models of TBI would further our understanding of the pathophysiology of TBI and develop new potential treatments. A multitude of animal TBI models have been used to replicate the various aspects of human TBI. …”
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978“…Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of cancer cells and adaptation to the tumor microenvironment. …”
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979“…A chemotherapeutic approach to cancer treatment poses a multitude of challenges, primarily due to the low selectivity and genotoxicity of the majority of chemotherapeutic drugs currently used in the clinical practice, often leading to treatment-induced tumors formation. …”
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980“…Further, basophils release a multitude of mediators, such as histamine and IL-31, which both play an important role in the initiation of the pruritic response via activation of sensory nerves. …”
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