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  1. 1441
    “…Embolization is a well-known and accepted form of treatment for bleeding caused by a multitude of renal procedures. We present a case of a 66-year-old woman who had a history of left nephrectomy for clear cell carcinoma seven years previously and now presented with a 6 cm tumor involving the solitary kidney. …”
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    Superselective renal artery embolization for treatment of urological hemorrhage after partial nephrectomy in a solitary kidney
  2. 1442
    por Jia, Xiuzhi, Zhao, Chunyuan, Zhao, Wei
    Publicado 2021
    “…The major histocompatibility complex (MHC) class I (MHC-I) region contains a multitude of genes relevant to immune response. Multiple E3 ubiquitin ligase genes, including tripartite motif 10 (TRIM10), TRIM15, TRIM26, TRIM27, TRIM31, TRIM38, TRIM39, TRIM40, and RING finger protein 39 (RNF39), are organized in a tight cluster, and an additional two TRIM genes (namely TRIM38 and TRIM27) telomeric of the cluster within the MHC-I region. …”
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    Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity
  3. 1443
    por Chinetti, Giulia, Neels, Jaap G.
    Publicado 2021
    “…Nuclear receptors are transcription factors widely expressed, activated by specific ligands that control the expression of target genes involved in a multitude of pathophysiological processes, including metabolism, cancer, inflammation and cell differentiation. …”
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    Roles of Nuclear Receptors in Vascular Calcification
  4. 1444
    “…We present Columba, a software tool written in C++, in which a multitude of search schemes are implemented. We discuss implementation aspects such as memory interleaving of Burrows-Wheeler transform representations and the reduction of redundancy that is inherently associated with the edit distance metric. …”
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    Dynamic partitioning of search patterns for approximate pattern matching using search schemes
  5. 1445
    por Deolal, Pallavi, Mishra, Krishnaveni
    Publicado 2021
    “…Chromatin packaging, nuclear and cytosolic protein organization, and nuclear membrane lipid homeostasis are critical determinants of overall nuclear morphology. As such, a multitude of molecular players and pathways act together to regulate the nuclear shape. …”
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    Regulation of diverse nuclear shapes: pathways working independently, together
  6. 1446
    “…Findings are presented from a study seeking to understand the constraints to older peoples’ access to outdoor recreation in Scotland, and this paper aimed to examine the multitude of constraints that discourage or prevent older people from accessing the outdoors and the ways in which these constraints are hierarchical (or not). …”
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    Outdoor Recreation for Older Adults in Scotland: Qualitatively Exploring the Multiplicity of Constraints to Participation
  7. 1447
    por Verma, Rupali
    Publicado 2021
    “…Such systems are interdisciplinary in nature with multitude of technologies contributing to its effective working. …”
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    Smart City Healthcare Cyber Physical System: Characteristics, Technologies  and Challenges
  8. 1448
    “…A few potassium-permeable ion channels exist in the outer membrane, while in the inner membrane, a multitude of different potassium-selective and potassium-permeable channels mediate K(+) uptake into energized mitochondria. …”
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    Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K(+) Channel
  9. 1449
    “…With neoplastic disease remaining a leading cause of death world-wide, the development of novel biomarkers aiding in the field of diagnosis, prognosis, and disease monitoring is of utmost importance. A multitude of studies have proven the association between the expression of members of the EPH/ephrin system and various clinicopathological parameters, including disease stage, tumor histologic grade, and patients’ overall survival. …”
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    The Clinical Impact of the EPH/Ephrin System in Cancer: Unwinding the Thread
  10. 1450
    “…The aberrant expression of ZNF521 transcripts, frequently associated with miRNA deregulation, has been detected in several tumors including pancreatic, hepatocellular, gastric, bladder transitional cell carcinomas as well as in breast and ovarian cancers. miRNA expression profiling tools are currently identifying a multitude of miRNAs, involved together with oncogenes and TFs in the regulation of oncogenesis, including ZNF521, which may be candidates for diagnostic and prognostic biomarkers of cancer.…”
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    Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers
  11. 1451
    “…Transport from and into the nucleus is essential to all eukaryotic life and occurs through the nuclear pore complex (NPC). There are a multitude of data supporting a role for nuclear transport in neurodegenerative diseases, but actual transport assays in disease models have provided diverse outcomes. …”
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    Measuring and Interpreting Nuclear Transport in Neurodegenerative Disease—The Example of C9orf72 ALS
  12. 1452
    “…Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed Parthenium hysterophorus (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. …”
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    Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects
  13. 1453
    “…The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1’s high evolvability hints that HIV-1 could adapt to a future vaccine. …”
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    RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection
  14. 1454
    “…In addition to improved speech intelligibility in quiet, noisy, and reverberant environments, binaural versus monaural listening improves perceived sound quality and decreases the effort listeners must expend to understand a target voice of interest or to monitor a multitude of potential target voices. For most individuals with bilateral hearing impairment, the body of evidence collected across decades of research has also found that the provision of two compared with one hearing aid yields significant benefit for the user. …”
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    Binaural Signal Processing in Hearing Aids
  15. 1455
    “…In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. …”
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    H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?
  16. 1456
    por Ramirez, Mary E. F., Dietz, Jill R.
    Publicado 2021
    “…PURPOSE OF REVIEW: The COVID-19 pandemic of 2020 presented a multitude of challenges for physicians nationwide. …”
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    Lessons Learned: Management of Breast Cancer Patients throughout the COVID-19 Pandemic
  17. 1457
    por Traidl, Stephan, Werfel, Thomas
    Publicado 2021
    “…Since the first report of allergen-specific immunotherapy (AIT) by Noon et al. 110 years ago, a multitude of clinical and in vitro studies have been performed to identify the effects of the only curative treatment for allergies. …”
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    Allergenimmuntherapie bei atopischer Dermatitis
  18. 1458
    por Cura, Vincent, Cavarelli, Jean
    Publicado 2021
    “…PRMT2 acts as a coactivator of several nuclear hormone receptors and is known to interact with a multitude of splicing-related proteins. Furthermore, PRMT2 is aberrantly expressed in several cancer types, including breast cancer and glioblastoma. …”
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    Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase
  19. 1459
    “…In sum, sanguiins appear to be promising compounds for additional studies, especially for their application in therapies for a multitude of common and debilitating ailments.…”
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    Sanguiins—Promising Molecules with Broad Biological Potential
  20. 1460
    “…We are currently witnessing a multitude of AI-related publications in the medicinal-chemistry-relevant literature and anticipate that the numbers will further increase. …”
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    Impact of Artificial Intelligence on Compound Discovery, Design, and Synthesis
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