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  1. 1681
    “…Significant progress has also been made in identifying the phenotype and signaling pathways specific for LSCs. Therapeutically, a multitude of drugs targeting LSCs are in different phases of preclinical and clinical development. …”
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    Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities
  2. 1682
    por Dietrich, Cornelia
    Publicado 2016
    “…It is generally accepted that the toxic responses of polycyclic aromatic hydrocarbons, dioxins, and structurally related compounds are mediated by activation of the AhR. A multitude of studies indicate that the AhR operates beyond xenobiotic metabolism and exerts pleiotropic functions. …”
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    Antioxidant Functions of the Aryl Hydrocarbon Receptor
  3. 1683
    “…Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. …”
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    Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice
  4. 1684
    “…This content can augment and improve our teaching methods but can be difficult to consolidate and present. A multitude of electronic learning management systems are available to help organize and serve this content though never with small residency programs as the target userbase. …”
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    Implementing an electronic learning management system for an Ophthalmology residency program
  5. 1685
    “…Phage display screening readily allows for the identification of a multitude of antibody specificities, but to identify optimal lead candidates remains a challenge. …”
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    Multivalent pIX phage display selects for distinct and improved antibody properties
  6. 1686
    “…Learning from data has led to paradigm shifts in a multitude of disciplines, including web, text and image search, speech recognition, as well as bioinformatics. …”
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    Quantum-chemical insights from deep tensor neural networks
  7. 1687
    “…Existing theories propose the emergence of a multitude of exotic quantum phases, distinguishable by either local point symmetry breaking or local spin expectation values, even in materials with simple cubic crystal structure such as Ba(2)NaOsO(6). …”
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    Magnetism and local symmetry breaking in a Mott insulator with strong spin orbit interactions
  8. 1688
    por Neumann, Peter, Blacquière, Tjeerd
    Publicado 2016
    “…Recent major losses of managed honeybee, Apis mellifera, colonies at a global scale have resulted in a multitude of research efforts to identify the underlying mechanisms. …”
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    The Darwin cure for apiculture? Natural selection and managed honeybee health
  9. 1689
    “…They vastly improved outcomes for patients, particularly those with genotype 1 infection, the most prevalent genotype globally. Since then, a multitude of DAAs have been licensed for use, and outcomes for patients have improved further, with fewer side effects and cure rates approaching 100%. …”
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    Hepatitis C treatment: where are we now?
  10. 1690
    “…The functional properties and technological utility of polycrystalline materials are largely determined by the structure, geometry, and spatial distribution of their multitude of crystals. However, crystallization is seeded through stochastic and incoherent nucleation events, limiting the ability to control or pattern the microstructure, texture, and functional properties of polycrystalline materials. …”
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    Programmable and coherent crystallization of semiconductors
  11. 1691
    “…Lysosomes, the major membrane-bound degradative organelles, have a multitude of functions in eukaryotic cells. Lysosomes are the terminal compartments in the endocytic pathway, though they display highly dynamic behaviors, fusing with each other and with late endosomes in the endocytic pathway, and with the plasma membrane during regulated exocytosis and for wound repair. …”
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    Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans
  12. 1692
    por Chmiliar, Linda
    Publicado 2017
    “…The iPad provides easy interaction on the touch screen and access to a multitude of engaging early learning applications. …”
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    Improving Learning Outcomes: The iPad and Preschool Children with Disabilities
  13. 1693
    “…PARPs are responsible for a post-translational modification, ADP-ribosylation, regulating a multitude of cellular events. T. brucei PARP, like human PARPs-1-3, is activated by DNA binding and it potentially functions in DNA repair processes. …”
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    Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma brucei
  14. 1694
    “…This case illustrates the clinical significance of considering a multitude of extrathymic paraneoplastic manifestations, each with a unique physiological mechanism.…”
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    Polyparaneoplastic Manifestations of Malignant Thymoma: A Unique Case of Myasthenia, Autoimmune Hepatitis, Pure Red Cell Aplasia, and Keratoconjunctivitis Sicca
  15. 1695
    “…Although mainly used for its anti-thrombotic, anti-pyretic, and analgesic properties, a multitude of clinical studies have provided convincing evidence that regular, low-dose aspirin use dramatically lowers the risk of cancer. …”
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    Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention
  16. 1696
    “…However, it suffers a high computational complexity due to a multitude of complex operations. In this paper, we propose a real-valued two-dimensional MUSIC algorithm based on conjugate centrosymmetric signal model, which is applicable to arbitrary centrosymmetric polarization sensitive array. …”
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    Real-Valued 2D MUSIC Algorithm Based on Modified Forward/Backward Averaging Using an Arbitrary Centrosymmetric Polarization Sensitive Array
  17. 1697
    “…For a given plant species, it is critical to sense and respond to salt stimuli followed by activation of multitude of mechanisms for plants to survive. Halophytes, the wonders of saline soils, have demonstrated ability to withstand and reproduce in at least 200 mM NaCl concentration, which makes them an ideal system to study mechanism of salt adaptation for imparting salt tolerance in glycophytes. …”
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    Looking at Halophytic Adaptation to High Salinity Through Genomics Landscape
  18. 1698
    “…The ultimate goal of this project is to host a multitude of available tasks, patient datasets, and analytic tools, facilitating large-scale data mining. …”
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    The Patient Repository for EEG Data + Computational Tools (PRED+CT)
  19. 1699
    “…Insulin is an important peptide hormone that regulates food intake and olfactory function. While a multitude of studies investigated the effect of insulin in the olfactory bulb and olfactory epithelium, research on how it modulates higher olfactory centers is lacking. …”
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    Insulin Modulates Neural Activity of Pyramidal Neurons in the Anterior Piriform Cortex
  20. 1700
    “…Often, the interpretation of experiments concerning the manipulation of the energy distribution of laser-accelerated ion bunches is complicated by the multitude of competing dynamic processes simultaneously contributing to recorded ion signals. …”
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    Isolated proton bunch acceleration by a petawatt laser pulse
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