Materias dentro de su búsqueda.
Mostrando 2,621 - 2,640 Resultados de 198,103 Para Buscar '"mutation"', tiempo de consulta: 0.57s Limitar resultados
  1. 2621
    “…We determined genomic alterations, mutational signatures related to etiology and histopathology and prognostic biomarkers. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mutational spectrum and precision oncology for biliary tract carcinoma
  2. 2622
    “…In this study, we have employed weighted PSNs to understand the influence of disease-causing mutations on proteins of known 3D structures. We have used manually curated information on disease mutations from UniProtKB/Swiss-Prot and their corresponding protein structures of wildtype and disease variant from the protein data bank. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Influence of Disease-Causing Mutations on Protein Structural Networks
  3. 2623
    “…Targeted therapies have used the properties of leukemic cells to produce altered metabolic products when mutated. This is the case of IDH1/2 mutations generating the abnormal conversion of α-ketoglutarate (KG) to 2-hydroxyglutarate, an oncometabolite inhibiting KG-dependent enzymes, such as the TET family of genes (pivotal in characterizing leukemia cells either by mutations, e.g., TET2, or by altered expression, e.g., TET1/2/3). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The Interactome between Metabolism and Gene Mutations in Myeloid Malignancies
  4. 2624
    “…BACKGROUND: Somatic gene mutations that facilitate inappropriate intracellular calcium entrance have been identified in most aldosterone-producing adenomas (APAs). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations
  5. 2625
    “…Virus adaptation correlated with mutations in the viral RNA polymerase, supporting that promiscuous thioredoxin recruitment was enabled by phenotypic mutations caused by transcription errors. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Evidence for a role of phenotypic mutations in virus adaptation
  6. 2626
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Biallelic IARS2 mutations presenting as sideroblastic anemia
  7. 2627
    “…It is evident that the SARS-CoV-2 variants pose an international health risk, the mutations of E484K and N501Y are the two most implicated mutations. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    COVID-19 and mutations a threat level assessment
  8. 2628
    “…BACKGROUND: Higher tumor mutation burden (TMB) in advanced non-small cell lung cancer (NSCLC) is associated with superior outcomes with checkpoint inhibitor therapy. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Effect of prior therapy on tumor mutational burden in NSCLC
  9. 2629
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Managing the Impact of a Mutating Global Crisis on Organizations
  10. 2630
    por Narayanan, Krishna K., Procko, Erik
    Publicado 2021
    “…Deep mutational scanning or deep mutagenesis is a powerful tool for understanding the sequence diversity available to viruses for adaptation in a laboratory setting. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Deep Mutational Scanning of Viral Glycoproteins and Their Host Receptors
  11. 2631
    “…The aim was to study the timing and types of device implantations and need for re-implantations in LMNA mutation carriers. METHODS: We studied the hospital records of 60 LMNA mutation carriers concerning device implantations and re-implantations and their indications. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Timing of pacemaker and ICD implantation in LMNA mutation carriers
  12. 2632
    “…On the base of structural data, kinetic studies, and mutation analysis, the key stages of APE1 interaction with damaged DNA were established. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity
  13. 2633
    “…Objectives To report a novel mutation of SOST gene in a patient with sclerosteosis. …”
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    A Novel Mutation in SOST Gene Causes Sclerosteosis
  14. 2634
    “…We identified 16 genes with recurrent somatic mutations and 7 core pathway modules. Among them, the Wnt/β-catenin pathway had the highest mutation rate, and the mutation frequency in Caucasians and Hispanics was approximately twice as high as that in Asians. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Trans-Ancestry Mutation Landscape of Hepatoblastoma Genomes in Children
  15. 2635
    “…Recently, patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast tumors. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    BRCA mutated pancreatic cancer: A change is coming
  16. 2636
    “…Hence, in the presence of BRCA mutations, the inhibition of the PARP pathway can lead to tumor cell death. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The role of PARP inhibitors in BRCA mutated pancreatic cancer
  17. 2637
    “…Additionally, the causative role of mitochondrial mutations and mitophagy malfunctions in NAFLD is discussed. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk
  18. 2638
    por Li, Siqi, Counter, Christopher M
    Publicado 2021
    “…RAS genes are commonly mutated in human cancer. Despite many possible mutations, individual cancer types often have a ‘tropism’ towards a specific subset of RAS mutations. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Signaling levels mold the RAS mutation tropism of urethane
  19. 2639
    “…The detection of three Gongylonema sp. infective larvae in two specimens of the dung beetle Geotrupes mutator (Marsham, 1802) from western Spain is reported here for the first time in Europe. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    First detection of Gongylonema species in Geotrupes mutator in Europe
  20. 2640
    “…The consequence of a mutation can be influenced by the context in which it operates. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Natural variants suppress mutations in hundreds of essential genes
Herramientas de búsqueda: RSS