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Mostrando 301 - 320 Resultados de 198,103 Para Buscar '"mutation"', tiempo de consulta: 0.60s Limitar resultados
  1. 301
    “…OBJECTIVES: Various genomic alterations and genomic signatures, including ERBB2 amplification, mutations in PIK3CA, AKT1, and ESR1, and tumor mutational burden (TMB), have become important biomarkers for treatment selection in breast cancer (BC). …”
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    Online Artículo Texto
    Characterization of Frequently Mutated Cancer Genes and Tumor Mutation Burden in Chinese Breast Cancer
  2. 302
    “…We identify H3.3(G34R) and IDH1/2 mutations as two such factors in ATRX-mutated glioblastomas. …”
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    Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
  3. 303
    por Saleh, Aya, Perets, Ruth
    Publicado 2021
    “…The majority of TP53 mutations are missense mutations, leading to loss of tumor suppressive function of p53 and gain of new oncogenic functions. …”
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    Mutated p53 in HGSC—From a Common Mutation to a Target for Therapy
  4. 304
    “…BACKGROUND: It has been shown that low-density lipoprotein receptor-related protein 1B (LRP1B) mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between LRP1B mutations and TMB in gastric cancer needs further study. …”
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    Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer
  5. 305
    por Zheng, Jia, Guo, Ning, Wagner, Andreas
    Publicado 2021
    “…Translational errors during protein synthesis cause phenotypic mutations that are several orders of magnitude more frequent than DNA mutations. …”
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    Mistranslation Reduces Mutation Load in Evolving Proteins through Negative Epistasis with DNA Mutations
  6. 306
    “…Mutational signatures are patterns of somatic alterations in the genome caused by carcinogenic exposures or aberrant cellular processes. …”
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    The Mutational Signature Comprehensive Analysis Toolkit (musicatk) for the Discovery, Prediction, and Exploration of Mutational Signatures
  7. 307
    “…Somatic mutations accumulate over time in cancer cells as a consequence of mutational processes. …”
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    Analysis of Mutations and Dysregulated Pathways Unravels Carcinogenic Effect and Clinical Actionability of Mutational Processes
  8. 308
    “…Here, our aim was to identify founder mutations leading to subsequent boosts in mutation load. …”
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    Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer
  9. 309
    “…BACKGROUND AND OBJECTIVES: To understand how organisms evolve, it is fundamental to study how mutations emerge and establish. Here, we estimated the rate of mutation accumulation of SARS-CoV-2 in vitro and investigated the repeatability of its evolution when facing a new cell type but no immune or drug pressures. …”
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    Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution
  10. 310
    “…The age of mutation was calculated to estimate the time at which the mutation occurred or the founder arrived in Taiwan. …”
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    PKD2 founder mutation is the most common mutation of polycystic kidney disease in Taiwan
  11. 311
    por Yicheng, Fu, Xin, Liu, Tian, Yu, Huilin, Liu
    Publicado 2022
    “…Methods: We collected relevant data of STAD patients from the Cancer Genome Atlas (TCGA), including somatic mutation, transcriptome, and survival data. We performed a series of analyses such as tumor mutational burden (TMB), immune infiltration, and copy number variation (CNV) analysis to evaluate the potential mechanism of filaggrin (FLG) mutation in gastric cancer. …”
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    Association of FLG mutation with tumor mutation load and clinical outcomes in patients with gastric cancer
  12. 312
    “…PURPOSE: Crystallin protein mutations are associated with congenital cataract (CC), and several disease-causing mutations in the CRYGC gene have been identified. …”
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    A Novel Mutation in CRYGC Mutation Associated with Autosomal Dominant Congenital Cataracts and Microcornea
  13. 313
    “…We investigated the clinical, mutational, and transcriptomic characteristics in elderly Korean individuals with CHIP mutations. …”
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    Clinical, Mutational, and Transcriptomic Characteristics in Elderly Korean Individuals With Clonal Hematopoiesis Driver Mutations
  14. 314
    “…Despite recent sequencing strategies, in our cohort a significant proportion of individuals with Usher type 2 have just one heterozygous disease-causing mutation in USH2A, or no convincing disease-causing mutations across nine Usher genes. …”
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    Screening for duplications, deletions and a common intronic mutation detects 35% of second mutations in patients with USH2A monoallelic mutations on Sanger sequencing
  15. 315
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    Corrigendum to “Mutation Spectrum of the ABCA4 Gene in a Greek Cohort with Stargardt Disease: Identification of Novel Mutations and Evidence of Three Prevalent Mutated Alleles”
  16. 316
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    EGFR-mutated pulmonary adenocarcinoma with concurrent PIK3CA mutation, and with acquired RET fusion and EGFR T790M mutation after afatinib therapy
  17. 317
    por Obuchowicz, Andrzej
    Publicado 2018
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    Stable mutations for evolutionary algorithms
  18. 318
    “…However, adaptive processes often rely on new mutations, which can be strongly influenced by predictable biases in mutation. …”
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    Mutation bias and the predictability of evolution
  19. 319
    “…Motivated by this case, we explored mtDNA mutations across 444 patients from ICGC and HIT cohorts. …”
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    Mitochondrial DNA mutations in Medulloblastoma
  20. 320
    “…Among the literature‐related to genetics of PKU, 18 studies were on the PKU mutations. According to these studies, in different populations of Iran 1497 patients were included for mutation detection that resulted in detection of 129 different mutations. …”
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    Mutational landscape of phenylketonuria in Iran
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