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324“…Ancillary procedures associated with plant transformation, including tissue culture and infection with A tumefaciens, can also introduce mutations. These genome-wide mutations can number from hundreds to many thousands per diploid genome. …”
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325“…Mutations are the ultimate fuel for evolution, but most mutations have a negative effect on fitness. …”
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326
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327por De Kruif, Paul H.“…Type G microbes, discovered in pure cultures of the rabbit septicemia bacillus, have been demonstrated to arise from the parent D form by mutation. The D → G mutation takes place in broth cultures of pure-line strains of Microbe D, when these are kept for several days without transplant at 37°C., or at room temperature, or in the ice box. …”
Publicado 1922
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328por Opatowski, I.“…Experiments on x-ray-induced mutations of the tobacco mosaic virus (Gowen) are analyzed on the basis of the ionization theory. …”
Publicado 1949
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331“…While modern DNA sequencing enables rapid identification of genetic variation, characterizing the phenotypic consequences of individual mutations remains a labor-intensive task. Here, we describe ADAM (Array-based Discovery of Adaptive Mutations), a technology that searches an entire bacterial genome for mutations that contribute to selectable phenotypic variation between an evolved strain and its parent. …”
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332
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333por Luzzatto, Lucio“…The analogy between evolution of organisms and evolution of cell populations is compelling: in both cases what drives change is mutation, but it is Darwinian selection that enables clones that have a growth advantage to expand, thus providing a larger target size for the next mutation to hit. …”
Publicado 2011
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334por Kirches, E“…The primary cause of the disease is usually a mutation of the mitochondrial genome (mtDNA) causing a single amino acid exchange in one of the mtDNA-encoded subunits of NADH:ubiquinone oxidoreductase, the first complex of the electron transport chain. …”
Publicado 2011
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335“…BACKGROUND: Gaucher's disease is an autosomal recessive, lysosomal storage disease caused by mutations of the β-glucocerebrosidase gene (GBA). There is increasing evidence that GBA mutations are a genetic risk factor for the development of Parkinson's disease (PD). …”
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336“…Functional effects of different mutations are known to combine to the total effect in highly nontrivial ways. …”
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337
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338por Aktay Ayaz, N, Bilginer, Y, Yilmaz, E, Ergüven, M, Topaloglu, R, Bakkaloglu, A, Ozen, SEnlace del recurso
Publicado 2008
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339“…Evolutionary game dynamics in finite populations assumes that all mutations are equally likely, i.e., if there are [Image: see text] strategies a single mutation can result in any strategy with probability [Image: see text]. …”
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340por Wilschanski, MichaelEnlace del recurso
Publicado 2012
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