Mostrando 361 - 380 Resultados de 198,103 Para Buscar '"mutation"', tiempo de consulta: 0.57s Limitar resultados
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    “…In one case, we identified a mutation in PLCG1 identical to a mutation observed previously in this gene in human visceral AS. …”
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    “…PROBLEM: We study the problem of identifying differentially mutated subnetworks of a large gene–gene interaction network, that is, subnetworks that display a significant difference in mutation frequency in two sets of cancer samples. …”
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  7. 367
    “…Doublecortin (DCX) mutations cause abnormal development of the DCX protein that normally aids in neuronal migration during fetal development. …”
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  8. 368
    por Srivastava, Ruby
    Publicado 2019
    “…Hydrogen bonds play a critical role in nucleobase studies as they encode genes, map protein structures, provide stability to the base pairs, and are involved in spontaneous and induced mutations. Proton transfer mechanism is a critical phenomenon that is related to the acid–base characteristics of the nucleobases in Watson–Crick base pairs. …”
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  9. 369
    “…One of these families also harbored a heterozygous LAMA3 mutation (c.1559G>A/p.Cys520Tyr) that cosegregated with both the AI phenotype and the ENAM mutation. …”
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  10. 370
    por Raynes, Yevgeniy, Weinreich, Daniel
    Publicado 2019
    “…The evolutionary fate of mutator mutations – genetic variants that raise the genome-wide mutation rate – in asexual populations is often described as being frequency (or number) dependent. …”
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  11. 371
    “…Some cancer therapies damage DNA and cause mutations both in cancer and healthy cells of the patient. …”
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  12. 372
    “…We also compare the mutational signatures to others in the literature. RESULTS: We apply a probabilistic mutation signature model to somatic mutations previously reported for six adult normal colon stem cells and 431 colon adenocarcinomas. …”
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  13. 373
    por Bley, Nadine
    Publicado 2020
    “…Mutations that allow tumors to evolve and become resistant to treatment can be readily identified with a new sequencing approach.…”
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  14. 374
    “…Analysis of the position of the resulting mutated residues in the protein reveals mutational hotspots. …”
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  15. 375
    “…Duchenne muscular dystrophy is a severe muscle wasting disease caused by mutations in the dystrophin gene (dmd). Ataluren has been approved by the European Medicines Agency for treatment of Duchenne muscular dystrophy. …”
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  16. 376
    “…This review summarizes the genetic and epigenetic insights of spliceosome mutations in UM. They form a distinct subgroup of UM and have similarities with other spliceosome mutated malignancies.…”
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    “…We develop the mathematical structure of the neutral coalescent with both replication-dependent and replication-independent mutations. This allows us to explain and quantify empirical results that explore differences in genetic diversity in bacterial cultures with different growth rates. …”
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