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Mostrando 661 - 680 Resultados de 198,103 Para Buscar '"mutation"', tiempo de consulta: 0.50s Limitar resultados
  1. 661
    por Luzzatto, Lucio
    Publicado 2011
    “…The analogy between evolution of organisms and evolution of cell populations is compelling: in both cases what drives change is mutation, but it is Darwinian selection that enables clones that have a growth advantage to expand, thus providing a larger target size for the next mutation to hit. …”
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    Correction: Somatic mutations in cancer development
  2. 662
    “…Mutational robustness of gene regulatory networks refers to their ability to generate constant biological output upon mutations that change network structure. …”
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    Mutational Robustness of Gene Regulatory Networks
  3. 663
    “…Evolutionary genetic models predict that the cumulative effect of rare deleterious mutations across the genome—known as mutational load burden—increases the susceptibility to complex disease. …”
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    Mutational load analysis of unrelated individuals
  4. 664
    “…Interestingly, four of the families were affected by multiple neuropsychiatric conditions, not limited to schizophrenia, and the mutations were detected in relatives with schizophrenia, depression and anxiety, drug and alcohol dependence, and epilepsy. …”
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    Deleterious GRM1 Mutations in Schizophrenia
  5. 665
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    ANP mutation causes reduced proteolysis
  6. 666
    por Miller, Judith R
    Publicado 2010
    “…Beneficial mutations can also surf, as can deleterious mutations over finite time spans. …”
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    Survival of mutations arising during invasions
  7. 667
    por O'Brien, Tom, Stokoe, David
    Publicado 2009
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    Converting cancer mutations into therapeutic opportunities
  8. 668
    “…Full mtDNA genome resequencing of 23 subjects, showed seven novel homoplasmic mutations, five were novel synonymous coding mutations. …”
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    Mitochondrial Mutations and Polymorphisms in Psychiatric Disorders
  9. 669
    por García, Julián, Traulsen, Arne
    Publicado 2012
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    Correction: The Structure of Mutations and the Evolution of Cooperation
  10. 670
    “…Most studies take a gene-based approach to identifying driver mutations, highlighting genes mutated in a large percentage of tumor samples as those likely to contain driver mutations. …”
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    Domain landscapes of somatic mutations in cancer
  11. 671
    “…They are clonal diseases arising in hematopoietic stem or progenitor cells. Mutations responsible for these diseases occur in several genes whose encoded proteins belong principally to five classes: signaling pathways proteins (e.g. …”
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    Myeloid malignancies: mutations, models and management
  12. 672
    “…To determine the frequency of mutations responsible for Gaucher's disease, we systematically sequenced the GBA1 gene as part of a molecular characterization of 73 adult patients in the United Kingdom. …”
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    Novel pathogenic mutations in the glucocerebrosidase locus
  13. 673
    por Veltman, Joris A
    Publicado 2011
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    De novo mutations in mental retardation
  14. 674
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    COSMIC: the catalogue of somatic mutations in cancer
  15. 675
    por Stuart, Joshua
    Publicado 2012
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    Pathway-based analysis of mutation impact
  16. 676
    “…The decrease in burst size due to mutations in TATA was promoter-dependent, but independent of other mutations. …”
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    Noise–mean relationship in mutated promoters
  17. 677
    “…We suggest that alternative but not mutually exclusive hypotheses explain the mutational dynamics of chloroplast genome evolution.…”
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    Mutational Dynamics of Aroid Chloroplast Genomes
  18. 678
    “…The F508del and S511A mutations generate different fragmentation fingerprints that are each unlike the wild-type; yet, both mutants generate new N-terminal-bearing CFTR fragments that are not observed with other CK2-related mutations (S511D, S422A/D and T1471A/D). …”
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    CFTR mutations altering CFTR fragmentation
  19. 679
    “…Recent studies on cTn mutations have provided plenty of evidence that HCM- and RCM-linked mutations increase cardiac myofilament Ca(2+) sensitivity, while DCM-linked mutations decrease it. …”
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    Inherited cardiomyopathies caused by troponin mutations
  20. 680
    por Sameer, Aga Syed
    Publicado 2013
    “…In this review I have focused on the mutations and polymorphisms of various important genes of the CIN and MIN pathways which have been implicated in the development of CRC.…”
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    Colorectal Cancer: Molecular Mutations and Polymorphisms
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