Mostrando 741 - 760 Resultados de 198,103 Para Buscar '"mutation"', tiempo de consulta: 0.53s Limitar resultados
  1. 741
    “…The prognostic significance of mutant IDH (mIDH) is controversial but appears to be influenced by co-mutational status and the specific location of the mutation (IDH1-R132, IDH2-R140, IDH2-R172). …”
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  2. 742
  3. 743
  4. 744
  5. 745
    “…Tumor growth is an evolutionary process involving accumulation of mutations, copy number alterations, and cancer stem cell (CSC) division and differentiation. …”
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  6. 746
    “…Using cross-sectional TCGA data, we computed evolutionary trajectories involving selectivity relationships among pairs of gene-specific genomic alterations such as somatic mutations, deletions, amplifications, downregulation, and upregulation among the top 20 driver genes associated with each cancer. …”
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  7. 747
    “…Close examination of one signal, an increased TCC [Formula: see text] TTC mutation rate in Europeans, indicates a burst of mutations from about 15,000 to 2000 years ago, perhaps due to the appearance, drift, and ultimate elimination of a genetic modifier of mutation rate. …”
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  8. 748
    “…Numerous human inherited diseases are caused by mutations that affect splicing, including mutations in proteins which are directly involved in splicing catalysis. …”
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  9. 749
    por Adjiri, Adouda
    Publicado 2017
    “…The present work discusses the role of DNA mutations as drivers and passengers in cancer initiation and development. …”
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  10. 750
  11. 751
    por Kakushadze, Zura, Yu, Willie
    Publicado 2017
    “…A majority of cancer types exhibit a mutation clustering structure. Our results are in-sample stable. …”
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  12. 752
  13. 753
  14. 754
    por Apell, Hans-Jürgen
    Publicado 2017
    “…Insufficient sodium-ion extrusion by mutated Na(+),K(+)-ATPases causes hyperaldosteronism.…”
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  15. 755
    “…Genetic testing was significant for an Arg302Gln mutation in the PRKAG2 gene. Cardiac tissue biopsy revealed significant myocyte hypertrophy and large vacuoles with glycogen stores. …”
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  16. 756
    “…BACKGROUND: A unified analysis of DNA sequences from hundreds of tumors concluded that the driver mutations primarily occur in the earliest stages of cancer formation, with relatively few driver mutation events detected in the late-arising subclones. …”
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  17. 757
  18. 758
    “…While mutational biases strongly influence neutral molecular evolution, the role of mutational biases in shaping the course of adaptation is less clear. …”
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  19. 759
    “…One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for developing antimicrobial resistance to nearly all available antipseudomonal agents through the selection of chromosomal mutations, leading to the failure of the treatment of severe hospital-acquired or chronic infections. …”
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  20. 760
    “…The mutation–selection process is the most fundamental mechanism of evolution. …”
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