“…BACKGROUND: KMT2D mutation (KMT2D(MT)) was found to play an important role in cancer immunity and response to immune checkpoint inhibitors (ICIs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This case report demonstrates a rare mutation pattern in a male patient with a pathologic diagnosis of non-small cell lung cancer (NSCLC) harboring an EGFR exon 19 deletion (19Del) mutation, who then acquired an EGFR-T790M mutation after developing resistance to the first generation EGFR-TKI (gefitinib). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this work we determine the transformations of these single-centered indices under mutations. Moreover, we generalize these mutations to quivers whose nodes carry single-centered indices different from unity. …”
Enlace del recurso
Enlace del recurso

“…The discussion is based on a number of new methods, in particular multiple scale analysis, nonlinear Markov processes and their entrance laws, atomic measure-valued evolutions and new forms of duality (for state-dependent mutation and multitype selection) which are used to prove ergodic theorems in this context and are applicable for many other questions and renormalization analysis for a variety of phenomena (stasis, punctuated equilibrium, failure of naive branching approximations, biodiversity) which occur due to the combination of rare mutation, mutation, resampling, migration and selection and make it necessary to mathematically bridge the gap (in the limit) between time and space scales.…”
Enlace del recurso
Enlace del recurso

“…Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Somatic mutations of calreticulin (CRT), an endoplasmic reticulum (ER)‐localized lectin chaperone, are driver mutations in approximately 25% of ET and 35% of MF patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A large-scale study of mutations in mitochondrial DNA has revealed a subset that do not accumulate with age.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For prioritization of noncoding mutations in imbalanced datasets, the ReMM score performed much better than other variation scores. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Increasing knowledge of the molecular features of myeloproliferative neoplasms (MPNs) is being combined with existing prognostic models based on clinical, laboratory, and cytogenetic information. Mutation-enhanced international prognostic systems (MIPSS) for polycythemia vera (PV) and essential thrombocythemia (ET) have improved prognostic assessments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SIMPLE SUMMARY: More than a third of all colorectal cancers have a KRAS mutation. The complex biology of these cancers has challenged the development of direct targeting inhibitors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, there was no increase in mutational burden, enrichment for certain mutational signatures or accumulation of structural variation to the genome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PM(2.5) increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mutation research is crucial for detecting and treating SARS-CoV-2 and developing vaccines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Epidermal growth factor receptor (EGFR) mutations are important events in carcinogenesis. The present study summarized the common germline mutations of EGFR, including T790M, V843I, R776H and P848L, and provided detailed information regarding each mutation site and potential treatment strategies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Most epidemiological models do not consider the role of mutations and heterogeneity in the type of contact events. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This approach formalizes our proposal that most mutations have a lower mutation rate than the average mutation rate measured experimentally. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Somatic mutations have important biological ramifications while exerting substantial rate, type, and genomic location heterogeneity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso