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1141“…Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. …”
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1142“…Pathogens that evolve resistance to drugs usually have reduced fitness. However, mutations that largely compensate for this reduction in fitness often arise. …”
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1143por Russell, Liane B.“…In attempts to find a prescreen for mutagens that may induce heritable mutations in mammals, an in vivo somatic mutation test has been developed in the mouse that uses a localized gene product (hair pigment), is relatively fast and cheap, and gives results that have some predictive value for point mutation induction in spermatogonia. …”
Publicado 1978
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1144
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1145“…Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. …”
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1146por Carter, Gregory W, Prinz, Susanne, Neou, Christine, Shelby, J Patrick, Marzolf, Bruz, Thorsson, Vesteinn, Galitski, Timothy“…For corresponding combinations of mutations, the network model predicted quantitative gene expression profiles and precise phenotypic effects. …”
Publicado 2007
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1147“…It is known that cancer is caused by an accumulation of mutations in DNA. Many genes have been associated with tumour progression either through germline or somatic mutations, but mutations in these genes by no means account for all instances of the disease. …”
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1148por Till, Bradley J, Cooper, Jennifer, Tai, Thomas H, Colowit, Peter, Greene, Elizabeth A, Henikoff, Steven, Comai, Luca“…CONCLUSION: We estimate that the density of induced mutations is two- to threefold higher than previously reported rice populations (about 1/300 kb). …”
Publicado 2007
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1149
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1150“…BACKGROUND: We recently reported a highly unexpected positive correlation between the fixation probability of nonsynonymous mutations (estimated by ω) and neutral mutation rate (estimated by K(s)) in mammalian lineages. …”
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1151por Fox, Maurice S.“…The breeder and the chemostat have been used to measure mutation rates for two mutations under a variety of steady state growth conditions. …”
Publicado 1955
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1152
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1153Publicado 1990“…This site is polymorphic since the normal allele was also present in all the patients tested. This mutation was not found in two unaffected family members and 11 normal controls. …”
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1154Publicado 1994“…In vivo studies in mice of the pathogenicity of the mutated antibodies show that a single amino acid substitution leading to a loss of dsDNA binding leads also to a loss of glomerular sequestration. …”
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1155
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1156
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1157
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1158“…Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by mutations in the [Formula: see text] gene that result in the defective development of [Formula: see text] regulatory T cells which constitute an important T cell subset involved in immune homeostasis and protection against autoimmunity. …”
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1159por Wasserstrom, Adam, Frumkin, Dan, Adar, Rivka, Itzkovitz, Shalev, Stern, Tomer, Kaplan, Shai, Shefer, Gabi, Shur, Irena, Zangi, Lior, Reizel, Yitzhak, Harmelin, Alon, Dor, Yuval, Dekel, Nava, Reisner, Yair, Benayahu, Dafna, Tzahor, Eldad, Segal, Eran, Shapiro, Ehud“…Here, we show a method for estimating the depth of a cell by analyzing somatic mutations in its microsatellites, and provide to our knowledge for the first time reliable depth estimates for several cells types in mice. …”
Publicado 2008
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1160“…The selection of candidates for BRCA germline mutation testing is an important clinical issue yet it remains a significant challenge. …”
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