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Mostrando 101 - 120 Resultados de 198,103 Para Buscar '"mutation"', tiempo de consulta: 0.73s Limitar resultados
  1. 101
    “…The acquisition of mutations plays critical roles in adaptation, evolution, senescence, and tumorigenesis. …”
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    Trajectory and uniqueness of mutational signatures in yeast mutators
  2. 102
    “…Many studies have performed cancer subtyping based on the type of frequently mutated genes, or the proportion of mutational processes. …”
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    Integrative analysis of mutated genes and mutational processes reveals novel mutational biomarkers in colorectal cancer
  3. 103
    “…Biased mutation spectra are pervasive, with wide variation in the magnitude of mutational biases that influence genome evolution and adaptation. …”
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    Shifts in mutation spectra enhance access to beneficial mutations
  4. 104
    “…Mutational processes and their exposures in particular genomes are key to our understanding of how these genomes are shaped. …”
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    A mutation-level covariate model for mutational signatures
  5. 105
    por Daiger, Stephen P.
    Publicado 2016
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    Mutations in Linkage Disequilibrium With Putative Disease-Causing Mutations
  6. 106
    “…However, mutations are often the cause of diseases. Thus, it is useful to have the capability to explore links between mutations and disease. …”
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    DES-Mutation: System for Exploring Links of Mutations and Diseases
  7. 107
    por Rajput, Manoj Kumar
    Publicado 2020
    “…Therefore, HBV spreads with mutations and variations. The mutations have been reported both in non-structural as well as structural genes of HBV genome. …”
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    Mutations and methods of analysis of mutations in Hepatitis B virus
  8. 108
    “…Additionally, in silico analysis of the binding of peptides containing the Leu30Val mutation to the human leukocyte antigen (HLA) molecules carried by the patient harboring this mutation suggested that the mutation could produce several novel immunogenic epitopes in this patient. …”
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    PLP1 Mutations in Patients with Multiple Sclerosis: Identification of a New Mutation and Potential Pathogenicity of the Mutations
  9. 109
    por Morrison, Patrick J
    Publicado 1997
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    Mutation Detection
  10. 110
    por D'Herelle, F.
    Publicado 1931
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    Bacterial Mutations
  11. 111
    “…Similar cancer types may nevertheless differ widely in the genetic mutations they carry. In this Closeup, Kristensen and Borresen-Dale discuss how identifying these mutations can define which therapy is most likely to succeed in eliminating the cancerous cells and how the methodology developed by Dias-Santagata et al and described in this issue, is an important step in making mutation screening a reality in the clinical practice worldwide.…”
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    Mutations for the people
  12. 112
    por Rider, Leah, Cramer, Scott D
    Publicado 2015
    “…Prostate cancers with mutations to a protein called SPOP use an error-prone method to repair broken DNA strands.…”
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    SPOP the mutation
  13. 113
    “…The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed.…”
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    Are There Mutator Polymerases?
  14. 114
    Publicado 1914
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    Bacterial Mutations
  15. 115
    “…Mutational hotspots, with recurrent mutations across cancer samples, represent genomic positions with elevated mutation rates, often caused by highly localized mutational processes. …”
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    Sequence dependencies and mutation rates of localized mutational processes in cancer
  16. 116
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    A potential hazard: explosive production of mutations by induction of mutators.
  17. 117
    por Anwar, Tamanna, Khan, Asad U
    Publicado 2006
    “…We describe MAP MUTATION (developed using PERL script) to quickly compare two strains and display mutational information and report specific positions where mutation has occurred. …”
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    MAP MUTATION: a program for analyzing mutations in protein sequences
  18. 118
    por Beckman, Robert A.
    Publicado 2009
    “…BACKGROUND: Tumorigenesis requires multiple genetic changes. Mutator mutations are mutations that increase genomic instability, and according to the mutator hypothesis, accelerate tumorigenesis by facilitating oncogenic mutations. …”
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    Mutator Mutations Enhance Tumorigenic Efficiency across Fitness Landscapes
  19. 119
    “…In vivo, oncogenic mutations have been shown to occur at exons 12, 13, and 61, resulting in any 1 of 19 possible point mutations in a given tumor for a specific RAS isoform. …”
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    RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally
  20. 120
    “…All cancers originate from a single cell that starts to behave abnormally due to the acquired somatic mutations in its genome. Until recently, the knowledge of the mutational processes that cause these somatic mutations has been very limited. …”
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    Mutational signatures: the patterns of somatic mutations hidden in cancer genomes()
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