Materias dentro de su búsqueda.
Mostrando 121 - 140 Resultados de 198,103 Para Buscar '"mutation"', tiempo de consulta: 0.62s Limitar resultados
  1. 121
    por Du, Chuance, Wu, Xiaoyuan, Li, Jia
    Publicado 2016
    “…BACKGROUND: Mutation rates are consistently varied in cancer genome and play an important role in tumorigenesis, however, little has been known about their function potential and impact on the distribution of functional mutations. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mutation pattern is an influential factor on functional mutation rates in cancer
  2. 122
    por Kasar, S., Brown, J. R.
    Publicado 2016
    “…Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature—that operate at different times throughout CLL evolution.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
  3. 123
    por Zhu, Wei, Wu, Song, Hannun, Yusuf A.
    Publicado 2017
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens
  4. 124
    “…BACKGROUND: Base substitution catalogues represent historical records of mutational processes that have been active in a cell. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    MutationalPatterns: comprehensive genome-wide analysis of mutational processes
  5. 125
    “…BACKGROUND: Cancer genes tend to be highly mutated under positive selection. Better understanding the recurrently mutated genes (RMGs) in cancer is critical for explicating the mechanisms of tumorigenesis and providing vital clues for therapy. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Genomic landscape and mutational impacts of recurrently mutated genes in cancers
  6. 126
    “…Recovery of Salmonella cells from the gall bladder of infected mice yields two types of isolates: (i) bile-resistant mutants; (ii) isolates that survive lethal selection without mutation. Bile-resistant mutants are recovered at frequencies high enough to suggest that increased mutation rates may occur in the gall bladder, thus providing a tentative example of stress-induced mutation in a natural environment. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mutational and non mutational adaptation of Salmonella enterica to the gall bladder
  7. 127
    “…Current molecular testing for selection of patients with gastrointestinal or pulmonary carcinomas relies on the prevalence of PD-L1 expression in tumor as well as immune cells by immunohistochemistry and/or on the evaluation of the microsatellite status. Tumor Mutational Burden (TMB) has emerged as a promising novel biomarker in this setting to further aid in patient selection. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Tumor mutation burden: from comprehensive mutational screening to the clinic
  8. 128
    “…Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene
  9. 129
    “…The mutational spectrum and prognostic factors of NRAS-mutated (NRAS(mut)) acute myeloid leukemia (AML) are largely unknown. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia
  10. 130
    “…We find that two particular mutation rates, G→U and C→U, are similarly elevated and considerably higher than all other mutation rates, causing the majority of mutations in the SARS-CoV-2 genome, and are possibly the result of APOBEC and ROS activity. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    MUTATION RATES AND SELECTION ON SYNONYMOUS MUTATIONS IN SARS-COV-2
  11. 131
    “…The infinite sites model of molecular evolution posits that every position in the genome is mutated at most once(1). By restricting the number of possible mutation histories, haplotypes and alleles, it forms a cornerstone of tumor phylogenetic analysis(2) and is often implied when calling, phasing and interpreting variants(3,4) or studying the mutational landscape as a whole(5). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Biallelic mutations in cancer genomes reveal local mutational determinants
  12. 132
    “…BACKGROUND: The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    MutationalPatterns: the one stop shop for the analysis of mutational processes
  13. 133
    “…Based on this analysis, a “mutation blacklist” of SARS-CoV-2 was compiled. The loci on the “mutation blacklist” are highly conserved, and these mutations likely have detrimental effects on virus survival, replication, and transmission. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    “Mutation blacklist” and “mutation whitelist” of SARS-CoV-2
  14. 134
    “…The increased mutation burdens were of multiple mutational signatures characterised by C > A changes. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
  15. 135
    por Pabst, T, Eyholzer, M, Fos, J, Mueller, B U
    Publicado 2009
    “…CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
  16. 136
    “…However, neither the rate of germline mutations in laboratory mice nor the biological significance of the mutation rate in mammalian populations is clear. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice
  17. 137
    Materias: “…Mutations in Brief…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Carpenter Syndrome: Extended RAB23 Mutation Spectrum and Analysis of Nonsense-mediated mRNA Decay
  18. 138
    “…Clustering of mutant pollen grains in a population of normal pollen due to premeiotic mutational events complicates translating mutation frequencies into rates. …”
    Enlace del recurso
    Enlace del recurso
    Texto
    Ontogeny of the barley plant as related to mutation expression and detection of pollen mutations.
  19. 139
    “…CONCLUSION: These results suggest a link of ATM gene deletion/mutation with rhabdomyosarcoma, and since ATM kinase is a crucial regulatory protein in DNA damage repair signaling pathway, and ATM deletion/mutation may contribute to pathogenesis of rhabdomyosarcoma.…”
    Enlace del recurso
    Enlace del recurso
    Texto
    Association of Ataxia Telangiectasia Mutated (ATM) gene mutation/deletion with Rhabdomyosarcoma
  20. 140
    “…Hum Mutat 31:1–11, 2010. © 2010 Wiley-Liss, Inc.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Cystathionine β-Synthase Mutations: Effect of Mutation Topology on Folding and Activity
Herramientas de búsqueda: RSS