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1901por Kaneko, Kunihiko“…Phenotype of biological systems needs to be robust against mutation in order to sustain themselves between generations. …”
Publicado 2007
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1902por Bangham, Jenny, Obbard, Darren J, Kim, Kang-Wook, Haddrill, Penelope R, Jiggins, Francis M“…Arms-race models propose that new host-resistance mutations or parasite counter-adaptations arise and sweep to fixation. …”
Publicado 2007
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1903por Qin, Jian, Calabrese, Peter, Tiemann-Boege, Irene, Shinde, Deepali Narendra, Yoon, Song-Ro, Gelfand, David, Bauer, Keith, Arnheim, Norman“…Unlike the disease site, similar analysis of C-to-G mutations at a control nucleotide site in one testis pair failed to find any foci with high mutation frequencies. …”
Publicado 2007
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1904“…The assessment of chromosomal mutations in children may provide information about aetiology and risk of second malignancies. …”
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1905por Tobal, K., Warren, W., Cooper, C. S., McCartney, A., Hungerford, J., Lightman, S.“…For two choroidal melanomas, we demonstrated that high levels of p53 protein were accompanied by exon 7 mutations. The mutations were found at codon 238, TGT-->TTT and codon 253, ACC-->AGC. …”
Publicado 1992
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1906“…Further, the effect of a mutation is also dependent on the sequence and structure context of the alteration. …”
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1907“…We suggest that the same mutations can cause either retinoma or retinoblastoma: benign hyperplastic nodules or retinoma when the mutations occur in relatively mature retinoblasts; and malignant retinoblastoma when the same mutations arise in immature retinoblasts. …”
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1908“…Of 30 samples obtained from patients with bladder cancer, eight (27%) were found to have RB gene mutations. DNA sequencing of the PCR products revealed five cases with single point mutations and three cases with small deletions. …”
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1909“…Phenotypic mutations are errors that occur during protein synthesis. …”
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1910
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1911por Ferrari, Simona, Lougaris, Vassilios, Caraffi, Stefano, Zuntini, Roberta, Yang, Jianying, Soresina, Annarosa, Meini, Antonella, Cazzola, Giantonio, Rossi, Cesare, Reth, Michael, Plebani, Alessandro“…These results indicate that mutations in Igβ can cause agammaglobulinemia in man.…”
Publicado 2007
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1912
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1913por De Kruif, Paul H.“…This changes during mutation, the resulting Type G mutants having in general an optimum lying between pH 4.7 and pH 3.8. …”
Publicado 1922
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1914Publicado 1994“…We analyzed the frequency of somatic mutation in immunoglobulin genes from hybridomas that secrete anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) monoclonal antibodies. …”
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1915por Maeda, Takahiro, Yamada, Yasuaki, Moriuchi, Ryozou, Sugahara, Kazuyuki, Tsuruda, Kazuto, Joh, Tatsurou, Atogami, Sunao, Tsukasaki, Kunihiro, Tomonaga, Masao, Kamihira, Shimeru“…Mutation of the Fas gene may be one of the mechanisms underlying the progression of ATL.…”
Publicado 1999
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1916“…A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. …”
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1917por Yuen, S. T., Chung, L. P., Leung, S. Y., Luk, I. S., Chan, S. Y., Ho, J. C., Ho, J. W., Wyllie, A. H.“…Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. …”
Publicado 1997
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1918“…The authentic acceptor sites affected by mutations were significantly weaker in exons with activated cryptic sites than in skipped exons. …”
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1919por Banci, Lucia, Bertini, Ivano, Boca, Mirela, Girotto, Stefania, Martinelli, Manuele, Valentine, Joan Selverstone, Vieru, Miguela“…There are about 100 single point mutations of copper, zinc superoxide dismutase 1 (SOD1) which are reported (http://alsod.iop.kcl.ac.uk/Als/index.aspx) to be related to the familial form (fALS) of amyotrophic lateral sclerosis (ALS). …”
Publicado 2008
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1920